Targeting B7-H3 enhances the efficacy of neoantigen-based cancer vaccine in combination with radiotherapy

Targeting B7-H3 enhances the efficacy of neoantigen-based cancer vaccine in combination with radiotherapy

Abstract The clinical response to immune checkpoint blockade (ICB) is limited in the majority of patients with colorectal cancer. These immune checkpoint proteins may not only inhibit T-cell-mediated antitumor immunity but also attenuate antigen presentation, including mutation-associated neoantigen...

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Main Authors: Tao-Wei Ke, Chia-Yi Chen, William Tzu-Liang Chen, Yuan-Yao Tsai, Shu-Fen Chiang, Chi-Hsien Huang, Yu-Sen Lin, Te-Hong Chen, Tsung-Wei Chen, Ji-An Liang, K. S. Clifford Chao, Kevin Chih-Yang Huang
Format: Article
Language:English
Published: Nature Portfolio 2025-04-01
Series:npj Vaccines
Online Access:https://doi.org/10.1038/s41541-025-01132-x
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