Angelica acutiloba Kitagawa Extract Attenuates DSS-Induced Murine Colitis
We examined the protective effects of Angelica acutiloba Kitagawa (AAK) extract on a murine model of acute experimental colitis. Colitis was induced by 4% dextran sulfate sodium (DSS) in the drinking water of male C57BL/6 mice, for 7 consecutive days. Oral administration of AAK extract (500 mg/kg/da...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2016/9275083 |
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| author | Jong-Chan Jang Kang Min Lee Seong-Gyu Ko |
| author_facet | Jong-Chan Jang Kang Min Lee Seong-Gyu Ko |
| author_sort | Jong-Chan Jang |
| collection | DOAJ |
| description | We examined the protective effects of Angelica acutiloba Kitagawa (AAK) extract on a murine model of acute experimental colitis. Colitis was induced by 4% dextran sulfate sodium (DSS) in the drinking water of male C57BL/6 mice, for 7 consecutive days. Oral administration of AAK extract (500 mg/kg/day) significantly alleviated DSS-induced symptoms such as anorexia, weight loss, events of diarrhea or bloody stools, and colon shortening. Histological damage was also ameliorated, as evidenced by the architectural preservation and suppression of inflammatory cell infiltration in colonic samples. Treatment improved the colonic mRNA expression of different inflammatory markers: cytokines, inducible enzymes, matrix metalloproteinases, and tight junction-related proteins. In the isolated serum, IgE levels were downregulated. Collectively, these findings indicate the therapeutic potentials of AAK as an effective complementary or alternative modality for the treatment of ulcerative colitis. |
| format | Article |
| id | doaj-art-fe328bf1381443e5976d44533b0e3600 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-fe328bf1381443e5976d44533b0e36002025-02-03T05:59:49ZengWileyMediators of Inflammation0962-93511466-18612016-01-01201610.1155/2016/92750839275083Angelica acutiloba Kitagawa Extract Attenuates DSS-Induced Murine ColitisJong-Chan Jang0Kang Min Lee1Seong-Gyu Ko2Department of Korean Medicine, College of Korean Medicine, Kyung Hee University, 26 Kyungheedae-ro, Dongdaemun-gu, Seoul 130-701, Republic of KoreaLaboratory of Clinical Biology and Pharmacogenomics, College of Korean Medicine, Kyung Hee University, 26 Kyungheedae-ro, Dongdaemun-gu, Seoul 130-701, Republic of KoreaLaboratory of Clinical Biology and Pharmacogenomics, College of Korean Medicine, Kyung Hee University, 26 Kyungheedae-ro, Dongdaemun-gu, Seoul 130-701, Republic of KoreaWe examined the protective effects of Angelica acutiloba Kitagawa (AAK) extract on a murine model of acute experimental colitis. Colitis was induced by 4% dextran sulfate sodium (DSS) in the drinking water of male C57BL/6 mice, for 7 consecutive days. Oral administration of AAK extract (500 mg/kg/day) significantly alleviated DSS-induced symptoms such as anorexia, weight loss, events of diarrhea or bloody stools, and colon shortening. Histological damage was also ameliorated, as evidenced by the architectural preservation and suppression of inflammatory cell infiltration in colonic samples. Treatment improved the colonic mRNA expression of different inflammatory markers: cytokines, inducible enzymes, matrix metalloproteinases, and tight junction-related proteins. In the isolated serum, IgE levels were downregulated. Collectively, these findings indicate the therapeutic potentials of AAK as an effective complementary or alternative modality for the treatment of ulcerative colitis.http://dx.doi.org/10.1155/2016/9275083 |
| spellingShingle | Jong-Chan Jang Kang Min Lee Seong-Gyu Ko Angelica acutiloba Kitagawa Extract Attenuates DSS-Induced Murine Colitis Mediators of Inflammation |
| title | Angelica acutiloba Kitagawa Extract Attenuates DSS-Induced Murine Colitis |
| title_full | Angelica acutiloba Kitagawa Extract Attenuates DSS-Induced Murine Colitis |
| title_fullStr | Angelica acutiloba Kitagawa Extract Attenuates DSS-Induced Murine Colitis |
| title_full_unstemmed | Angelica acutiloba Kitagawa Extract Attenuates DSS-Induced Murine Colitis |
| title_short | Angelica acutiloba Kitagawa Extract Attenuates DSS-Induced Murine Colitis |
| title_sort | angelica acutiloba kitagawa extract attenuates dss induced murine colitis |
| url | http://dx.doi.org/10.1155/2016/9275083 |
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