Thyroid-Associated Ophthalmopathy after Radioactive Iodine Therapy for Metastatic Follicular Thyroid Carcinoma
Thyroid-associated ophthalmopathy (TAO) is an inflammation of the extraocular muscles and periorbital connective tissue caused by autoantibodies against common antigens to both the thyroid and orbit. The release of antigens and induction of hypothyroidism caused by radioactive iodine (RAI) therapy m...
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | Case Reports in Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2021/3024639 |
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| author | Daisuke Murayama Soji Toda Yoichiro Okubo Hiroyuki Hayashi Ai Matsui Mio Yasukawa Hiroyuki Iwasaki |
| author_facet | Daisuke Murayama Soji Toda Yoichiro Okubo Hiroyuki Hayashi Ai Matsui Mio Yasukawa Hiroyuki Iwasaki |
| author_sort | Daisuke Murayama |
| collection | DOAJ |
| description | Thyroid-associated ophthalmopathy (TAO) is an inflammation of the extraocular muscles and periorbital connective tissue caused by autoantibodies against common antigens to both the thyroid and orbit. The release of antigens and induction of hypothyroidism caused by radioactive iodine (RAI) therapy may exacerbate TAO. Here, we present the case of a 67-year-old-woman treated with RAI therapy for metastatic follicular thyroid carcinoma who presented with TAO during the course of sorafenib administration. Tg and TgAb levels were gradually decreased with sorafenib and lenvatinib treatment, and TAO was improved without any ophthalmologic treatment. |
| format | Article |
| id | doaj-art-fe2d43ca98df440c8b7569a930174107 |
| institution | Kabale University |
| issn | 2090-6501 2090-651X |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Endocrinology |
| spelling | doaj-art-fe2d43ca98df440c8b7569a9301741072025-02-03T05:43:48ZengWileyCase Reports in Endocrinology2090-65012090-651X2021-01-01202110.1155/2021/30246393024639Thyroid-Associated Ophthalmopathy after Radioactive Iodine Therapy for Metastatic Follicular Thyroid CarcinomaDaisuke Murayama0Soji Toda1Yoichiro Okubo2Hiroyuki Hayashi3Ai Matsui4Mio Yasukawa5Hiroyuki Iwasaki6Department of Breast and Endocrine Surgery, Kanagawa Cancer Center, 2-3-2 Nakao Asahi-ku, Yokohama, Kanagawa 241-8515, JapanDepartment of Breast and Endocrine Surgery, Kanagawa Cancer Center, 2-3-2 Nakao Asahi-ku, Yokohama, Kanagawa 241-8515, JapanDepartment of Pathology, Kanagawa Cancer Center, 2-3-2 Nakao Asahi-ku, Yokohama, Kanagawa 241-8515, JapanDepartment of Pathology, Yokohama Municipal Citizen’s Hospital, 1-1 Mitsuzawanishicho Kanagawa-ku, Yokohama, Kanagawa 221-0855, JapanDepartment of Breast and Endocrine Surgery, Kanagawa Cancer Center, 2-3-2 Nakao Asahi-ku, Yokohama, Kanagawa 241-8515, JapanDepartment of Breast and Endocrine Surgery, Kanagawa Cancer Center, 2-3-2 Nakao Asahi-ku, Yokohama, Kanagawa 241-8515, JapanDepartment of Breast and Endocrine Surgery, Kanagawa Cancer Center, 2-3-2 Nakao Asahi-ku, Yokohama, Kanagawa 241-8515, JapanThyroid-associated ophthalmopathy (TAO) is an inflammation of the extraocular muscles and periorbital connective tissue caused by autoantibodies against common antigens to both the thyroid and orbit. The release of antigens and induction of hypothyroidism caused by radioactive iodine (RAI) therapy may exacerbate TAO. Here, we present the case of a 67-year-old-woman treated with RAI therapy for metastatic follicular thyroid carcinoma who presented with TAO during the course of sorafenib administration. Tg and TgAb levels were gradually decreased with sorafenib and lenvatinib treatment, and TAO was improved without any ophthalmologic treatment.http://dx.doi.org/10.1155/2021/3024639 |
| spellingShingle | Daisuke Murayama Soji Toda Yoichiro Okubo Hiroyuki Hayashi Ai Matsui Mio Yasukawa Hiroyuki Iwasaki Thyroid-Associated Ophthalmopathy after Radioactive Iodine Therapy for Metastatic Follicular Thyroid Carcinoma Case Reports in Endocrinology |
| title | Thyroid-Associated Ophthalmopathy after Radioactive Iodine Therapy for Metastatic Follicular Thyroid Carcinoma |
| title_full | Thyroid-Associated Ophthalmopathy after Radioactive Iodine Therapy for Metastatic Follicular Thyroid Carcinoma |
| title_fullStr | Thyroid-Associated Ophthalmopathy after Radioactive Iodine Therapy for Metastatic Follicular Thyroid Carcinoma |
| title_full_unstemmed | Thyroid-Associated Ophthalmopathy after Radioactive Iodine Therapy for Metastatic Follicular Thyroid Carcinoma |
| title_short | Thyroid-Associated Ophthalmopathy after Radioactive Iodine Therapy for Metastatic Follicular Thyroid Carcinoma |
| title_sort | thyroid associated ophthalmopathy after radioactive iodine therapy for metastatic follicular thyroid carcinoma |
| url | http://dx.doi.org/10.1155/2021/3024639 |
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