The Principal of Dynamic Contrast Enhanced MRI, the Method of Pharmacokinetic Analysis, and Its Application in the Head and Neck Region
Many researchers have established the utility of the dynamic contrast enhanced-magnetic resonance imaging (DCE-MRI) in the differential diagnosis in the head and neck region, especially in the salivary gland tumors. The subjective assessment of the pattern of the time-intensity curve (TIC) or the si...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | International Journal of Dentistry |
| Online Access: | http://dx.doi.org/10.1155/2012/480659 |
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| author | Toru Chikui Makoto Obara Arjan W. Simonetti Masahiro Ohga Shoichi Koga Shintaro Kawano Yoshio Matsuo Takeshi Kamintani Tomoko Shiraishi Erina Kitamoto Katsumasa Nakamura Kazunori Yoshiura |
| author_facet | Toru Chikui Makoto Obara Arjan W. Simonetti Masahiro Ohga Shoichi Koga Shintaro Kawano Yoshio Matsuo Takeshi Kamintani Tomoko Shiraishi Erina Kitamoto Katsumasa Nakamura Kazunori Yoshiura |
| author_sort | Toru Chikui |
| collection | DOAJ |
| description | Many researchers have established the utility of the dynamic contrast enhanced-magnetic resonance imaging (DCE-MRI) in the differential diagnosis in the head and neck region, especially in the salivary gland tumors. The subjective assessment of the pattern of the time-intensity curve (TIC) or the simple quantification of the TIC, such as the time to peak enhancement () and the wash-out ratio (WR), is commonly used. Although the semiquantitative evaluations described above have been widely applied, they do not provide information on the underlying pharmacokinetic analysis in tissue.
The quantification of DCE-MRI is preferable; therefore, many compartment model analyses have been proposed. The Toft and Kermode (TK) model is one of the most popular compartment models, which provide information about the influx forward volume transfer constant from plasma into the extravascular-extracellular space (EES) and the fractional volume of EES per unit volume of tissue is used in many clinical studies. This paper will introduce the method of pharmacokinetic analysis and also describe the clinical application of this technique in the head and neck region. |
| format | Article |
| id | doaj-art-fe288226c8a949afa25328bdc37f0cea |
| institution | Kabale University |
| issn | 1687-8728 1687-8736 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Dentistry |
| spelling | doaj-art-fe288226c8a949afa25328bdc37f0cea2025-02-03T01:10:42ZengWileyInternational Journal of Dentistry1687-87281687-87362012-01-01201210.1155/2012/480659480659The Principal of Dynamic Contrast Enhanced MRI, the Method of Pharmacokinetic Analysis, and Its Application in the Head and Neck RegionToru Chikui0Makoto Obara1Arjan W. Simonetti2Masahiro Ohga3Shoichi Koga4Shintaro Kawano5Yoshio Matsuo6Takeshi Kamintani7Tomoko Shiraishi8Erina Kitamoto9Katsumasa Nakamura10Kazunori Yoshiura11Department of Oral and Maxillofacial Radiology, Faculty of Dental Science, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, JapanPhilips Electronics Japan, Ltd. 2-13-37 Konan, Minato-ku, Tokyo 108-85 07, JapanImaging Systems, Philips Healthcare, Best, The NetherlandsRadiology Center, Kyushu University Hospital, Kyushu University, Fukuoka 812-85 82, JapanRadiology Center, Kyushu University Hospital, Kyushu University, Fukuoka 812-85 82, JapanSection of Oral and Maxillofacial Oncology, Division of Maxillofacial Diagnostic and Surgical Sciences, Faculty of Dental Science, Kyushu University, Fukuoka, JapanDepartment of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, JapanDepartment of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, JapanSection of Image Diagnosis, Department of Diagnostics and General Care, Fukuoka Dental College, Fukuoka 814-0193, JapanDepartment of Oral and Maxillofacial Radiology, Faculty of Dental Science, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, JapanDepartment of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, JapanDepartment of Oral and Maxillofacial Radiology, Faculty of Dental Science, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, JapanMany researchers have established the utility of the dynamic contrast enhanced-magnetic resonance imaging (DCE-MRI) in the differential diagnosis in the head and neck region, especially in the salivary gland tumors. The subjective assessment of the pattern of the time-intensity curve (TIC) or the simple quantification of the TIC, such as the time to peak enhancement () and the wash-out ratio (WR), is commonly used. Although the semiquantitative evaluations described above have been widely applied, they do not provide information on the underlying pharmacokinetic analysis in tissue. The quantification of DCE-MRI is preferable; therefore, many compartment model analyses have been proposed. The Toft and Kermode (TK) model is one of the most popular compartment models, which provide information about the influx forward volume transfer constant from plasma into the extravascular-extracellular space (EES) and the fractional volume of EES per unit volume of tissue is used in many clinical studies. This paper will introduce the method of pharmacokinetic analysis and also describe the clinical application of this technique in the head and neck region.http://dx.doi.org/10.1155/2012/480659 |
| spellingShingle | Toru Chikui Makoto Obara Arjan W. Simonetti Masahiro Ohga Shoichi Koga Shintaro Kawano Yoshio Matsuo Takeshi Kamintani Tomoko Shiraishi Erina Kitamoto Katsumasa Nakamura Kazunori Yoshiura The Principal of Dynamic Contrast Enhanced MRI, the Method of Pharmacokinetic Analysis, and Its Application in the Head and Neck Region International Journal of Dentistry |
| title | The Principal of Dynamic Contrast Enhanced MRI, the Method of Pharmacokinetic Analysis, and Its Application in the Head and Neck Region |
| title_full | The Principal of Dynamic Contrast Enhanced MRI, the Method of Pharmacokinetic Analysis, and Its Application in the Head and Neck Region |
| title_fullStr | The Principal of Dynamic Contrast Enhanced MRI, the Method of Pharmacokinetic Analysis, and Its Application in the Head and Neck Region |
| title_full_unstemmed | The Principal of Dynamic Contrast Enhanced MRI, the Method of Pharmacokinetic Analysis, and Its Application in the Head and Neck Region |
| title_short | The Principal of Dynamic Contrast Enhanced MRI, the Method of Pharmacokinetic Analysis, and Its Application in the Head and Neck Region |
| title_sort | principal of dynamic contrast enhanced mri the method of pharmacokinetic analysis and its application in the head and neck region |
| url | http://dx.doi.org/10.1155/2012/480659 |
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