Very late relapse of Burkitt's lymphoma in an EBV-negative patient after 20 years of complete remission
Burkitt's lymphoma (BL) is an aggressive B-cell lymphoma that occurs in children and adults. It is a chemosensitive lymphoma with very exceptional cases of late relapse.We report the case of a 32-year-old male, originally from a nonendemic area for BL, who was successfully treated for abdominal...
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Elsevier
2024-01-01
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| Series: | Leukemia Research Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213048924000608 |
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| author | Kmar Mrad Nader Slama Nouha Ben Abdeljalil Zaineb Mlayah Wiem Boufrikha Abdelfattah Zakhama Sarra Boukhris Mohamed Adnene Laatiri |
| author_facet | Kmar Mrad Nader Slama Nouha Ben Abdeljalil Zaineb Mlayah Wiem Boufrikha Abdelfattah Zakhama Sarra Boukhris Mohamed Adnene Laatiri |
| author_sort | Kmar Mrad |
| collection | DOAJ |
| description | Burkitt's lymphoma (BL) is an aggressive B-cell lymphoma that occurs in children and adults. It is a chemosensitive lymphoma with very exceptional cases of late relapse.We report the case of a 32-year-old male, originally from a nonendemic area for BL, who was successfully treated for abdominal BL 20 years ago. He described a two-month history of cervical swelling and a one-week history of dyspnea. Physical examination was unremarkable except for a left submandibular mass that extended to the collarbone. An ultrasound of the neck revealed cervical lymphadenopathy. The patient was submitted to a lymph node biopsy with an immunohistochemical analysis, which concluded to the diagnosis of BL. Screening for recent Epstein-Barr-Virus (EBV) infection was negative. We considered this a very late relapse (VLR) of the original disease, and the patient was treated according to the same initial protocol. Unfortunately, he suffered a second relapse and died.We report an unusual case of a VLR of nonendemic BL in an EBV-negative patient, occurring 20 years after achieving complete remission following the initial chemotherapy. |
| format | Article |
| id | doaj-art-fdeee5e9a6c84242af1a4f0a06b5dce5 |
| institution | OA Journals |
| issn | 2213-0489 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Leukemia Research Reports |
| spelling | doaj-art-fdeee5e9a6c84242af1a4f0a06b5dce52025-08-20T02:19:37ZengElsevierLeukemia Research Reports2213-04892024-01-012210047010.1016/j.lrr.2024.100470Very late relapse of Burkitt's lymphoma in an EBV-negative patient after 20 years of complete remissionKmar Mrad0Nader Slama1Nouha Ben Abdeljalil2Zaineb Mlayah3Wiem Boufrikha4Abdelfattah Zakhama5Sarra Boukhris6Mohamed Adnene Laatiri7Hematology Department, Fattouma Bourguiba University Hospital of Monastir, Avenue Farhat Hached, Monastir, 5000, Tunisia; Corresponding author at: Hematology Department, Fattouma Bourguiba University Hospital of Monastir, Avenue Farhat Hached, Monastir 5000, Tunisia.Hematology Department, Fattouma Bourguiba University Hospital of Monastir, Avenue Farhat Hached, Monastir, 5000, TunisiaPathology Department, Fattouma Bourguiba University Hospital of Monastir, Avenue Farhat Hached, Monastir, 5000, TunisiaHematology Department, Fattouma Bourguiba University Hospital of Monastir, Avenue Farhat Hached, Monastir, 5000, TunisiaHematology Department, Fattouma Bourguiba University Hospital of Monastir, Avenue Farhat Hached, Monastir, 5000, TunisiaPathology Department, Fattouma Bourguiba University Hospital of Monastir, Avenue Farhat Hached, Monastir, 5000, TunisiaHematology Department, Fattouma Bourguiba University Hospital of Monastir, Avenue Farhat Hached, Monastir, 5000, TunisiaHematology Department, Fattouma Bourguiba University Hospital of Monastir, Avenue Farhat Hached, Monastir, 5000, TunisiaBurkitt's lymphoma (BL) is an aggressive B-cell lymphoma that occurs in children and adults. It is a chemosensitive lymphoma with very exceptional cases of late relapse.We report the case of a 32-year-old male, originally from a nonendemic area for BL, who was successfully treated for abdominal BL 20 years ago. He described a two-month history of cervical swelling and a one-week history of dyspnea. Physical examination was unremarkable except for a left submandibular mass that extended to the collarbone. An ultrasound of the neck revealed cervical lymphadenopathy. The patient was submitted to a lymph node biopsy with an immunohistochemical analysis, which concluded to the diagnosis of BL. Screening for recent Epstein-Barr-Virus (EBV) infection was negative. We considered this a very late relapse (VLR) of the original disease, and the patient was treated according to the same initial protocol. Unfortunately, he suffered a second relapse and died.We report an unusual case of a VLR of nonendemic BL in an EBV-negative patient, occurring 20 years after achieving complete remission following the initial chemotherapy.http://www.sciencedirect.com/science/article/pii/S2213048924000608B-cell lymphomaBurkitt lymphomaChemotherapyRecurrence |
| spellingShingle | Kmar Mrad Nader Slama Nouha Ben Abdeljalil Zaineb Mlayah Wiem Boufrikha Abdelfattah Zakhama Sarra Boukhris Mohamed Adnene Laatiri Very late relapse of Burkitt's lymphoma in an EBV-negative patient after 20 years of complete remission Leukemia Research Reports B-cell lymphoma Burkitt lymphoma Chemotherapy Recurrence |
| title | Very late relapse of Burkitt's lymphoma in an EBV-negative patient after 20 years of complete remission |
| title_full | Very late relapse of Burkitt's lymphoma in an EBV-negative patient after 20 years of complete remission |
| title_fullStr | Very late relapse of Burkitt's lymphoma in an EBV-negative patient after 20 years of complete remission |
| title_full_unstemmed | Very late relapse of Burkitt's lymphoma in an EBV-negative patient after 20 years of complete remission |
| title_short | Very late relapse of Burkitt's lymphoma in an EBV-negative patient after 20 years of complete remission |
| title_sort | very late relapse of burkitt s lymphoma in an ebv negative patient after 20 years of complete remission |
| topic | B-cell lymphoma Burkitt lymphoma Chemotherapy Recurrence |
| url | http://www.sciencedirect.com/science/article/pii/S2213048924000608 |
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