Hybrid microstructure-based stretchable biosensors for multi-physiological signal sensing
Wearable biosensors provide continuous, real-time physiological monitoring of biochemical markers in biofluids such as sweat, tears, saliva, and interstitial fluid. However, achieving high stretchability and stable biochemical signal monitoring remains challenging. Here, we propose a hybrid microstr...
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| Main Authors: | , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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KeAi Communications Co. Ltd.
2025-03-01
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| Series: | eScience |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2667141724001265 |
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| author | Fei Han Hanfei Li Laixin Huang Xiaomeng Zhou Rui Su Huan Yu Qiong Tian Hang Zhao Qingsong Li Jing Sun Mei Yu Xinping Deng Guanglin Li Huaiyu Ye Fei Li Guoqi Zhang Zhiyuan Liu |
| author_facet | Fei Han Hanfei Li Laixin Huang Xiaomeng Zhou Rui Su Huan Yu Qiong Tian Hang Zhao Qingsong Li Jing Sun Mei Yu Xinping Deng Guanglin Li Huaiyu Ye Fei Li Guoqi Zhang Zhiyuan Liu |
| author_sort | Fei Han |
| collection | DOAJ |
| description | Wearable biosensors provide continuous, real-time physiological monitoring of biochemical markers in biofluids such as sweat, tears, saliva, and interstitial fluid. However, achieving high stretchability and stable biochemical signal monitoring remains challenging. Here, we propose a hybrid microstructure (HMS) strategy to fabricate highly stretchable multifunctional biosensors capable of detecting sweat electrolyte concentrations, pH levels, and surface electromyography (EMG) signals. By integrating a HMS, stable conductivity under large strains is ensured. Stretching tests up to 5000 cycles demonstrated the electrodes’ stretchable stability and reliability. The high-performance electrodes were used for EMG monitoring on human skin. Additionally, active materials were coated onto the stretchable electrodes to create multifunctional sweat sensors capable of monitoring pH as well as calcium, sodium, and potassium ions (Ca2+, Na+, K+). The electrodes reliably maintained their functionality under 60% strain, providing new insights into the fabrication of stable, highly stretchable biosensors. |
| format | Article |
| id | doaj-art-fdebc5c75cc84a7f8d4fe73d96b8f74f |
| institution | OA Journals |
| issn | 2667-1417 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | KeAi Communications Co. Ltd. |
| record_format | Article |
| series | eScience |
| spelling | doaj-art-fdebc5c75cc84a7f8d4fe73d96b8f74f2025-08-20T02:10:58ZengKeAi Communications Co. Ltd.eScience2667-14172025-03-015210032710.1016/j.esci.2024.100327Hybrid microstructure-based stretchable biosensors for multi-physiological signal sensingFei Han0Hanfei Li1Laixin Huang2Xiaomeng Zhou3Rui Su4Huan Yu5Qiong Tian6Hang Zhao7Qingsong Li8Jing Sun9Mei Yu10Xinping Deng11Guanglin Li12Huaiyu Ye13Fei Li14Guoqi Zhang15Zhiyuan Liu16Neural Engineering Centre, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China; Academy for Engineering and Technology, Fudan University, Shanghai 200433, ChinaNeural Engineering Centre, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, ChinaResearch Center for Advanced Detection Materials and Medical Imaging Devices, Shenzhen Institute of Advanced Technology, Key Laboratory of Biomedical Imaging Science and System, Chinese Academy of Sciences, Shenzhen 518055, ChinaNeural Engineering Centre, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, ChinaNeural Engineering Centre, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, ChinaNeural Engineering Centre, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, ChinaNeural Engineering Centre, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, ChinaNeural Engineering Centre, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, ChinaNeural Engineering Centre, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, ChinaNeural Engineering Centre, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, ChinaNeural Engineering Centre, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, ChinaNeural Engineering Centre, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, ChinaNeural Engineering Centre, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, ChinaEngineering Research Center of Integrated Circuits for Next-Generation Communications, Ministry of Education, School of Microelectronics, Southern University of Science and Technology, Shenzhen 518055, China; Corresponding authors.Research Center for Advanced Detection Materials and Medical Imaging Devices, Shenzhen Institute of Advanced Technology, Key Laboratory of Biomedical Imaging Science and System, Chinese Academy of Sciences, Shenzhen 518055, China; Corresponding authors.Academy for Engineering and Technology, Fudan University, Shanghai 200433, China; Faculty of EEMCS, Delft University of Technology, Mekelweg 4, 2628 CD Delft, Netherlands; Corresponding authors.Neural Engineering Centre, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China; Research Center for Advanced Detection Materials and Medical Imaging Devices, Shenzhen Institute of Advanced Technology, Key Laboratory of Biomedical Imaging Science and System, Chinese Academy of Sciences, Shenzhen 518055, China; Standard Robots Co., Ltd, Room 405, Building D, Huafeng International Robot Fusen Industrial Park, Hangcheng Avenue, Guxing Community, Xixiang Street, Baoan District, Shenzhen 518000, China; Corresponding authors.Wearable biosensors provide continuous, real-time physiological monitoring of biochemical markers in biofluids such as sweat, tears, saliva, and interstitial fluid. However, achieving high stretchability and stable biochemical signal monitoring remains challenging. Here, we propose a hybrid microstructure (HMS) strategy to fabricate highly stretchable multifunctional biosensors capable of detecting sweat electrolyte concentrations, pH levels, and surface electromyography (EMG) signals. By integrating a HMS, stable conductivity under large strains is ensured. Stretching tests up to 5000 cycles demonstrated the electrodes’ stretchable stability and reliability. The high-performance electrodes were used for EMG monitoring on human skin. Additionally, active materials were coated onto the stretchable electrodes to create multifunctional sweat sensors capable of monitoring pH as well as calcium, sodium, and potassium ions (Ca2+, Na+, K+). The electrodes reliably maintained their functionality under 60% strain, providing new insights into the fabrication of stable, highly stretchable biosensors.http://www.sciencedirect.com/science/article/pii/S2667141724001265Hybrid microstructureStretchable electrodeStretchable biosensorsMultifunctional sweat sensorsWearable electronics |
| spellingShingle | Fei Han Hanfei Li Laixin Huang Xiaomeng Zhou Rui Su Huan Yu Qiong Tian Hang Zhao Qingsong Li Jing Sun Mei Yu Xinping Deng Guanglin Li Huaiyu Ye Fei Li Guoqi Zhang Zhiyuan Liu Hybrid microstructure-based stretchable biosensors for multi-physiological signal sensing eScience Hybrid microstructure Stretchable electrode Stretchable biosensors Multifunctional sweat sensors Wearable electronics |
| title | Hybrid microstructure-based stretchable biosensors for multi-physiological signal sensing |
| title_full | Hybrid microstructure-based stretchable biosensors for multi-physiological signal sensing |
| title_fullStr | Hybrid microstructure-based stretchable biosensors for multi-physiological signal sensing |
| title_full_unstemmed | Hybrid microstructure-based stretchable biosensors for multi-physiological signal sensing |
| title_short | Hybrid microstructure-based stretchable biosensors for multi-physiological signal sensing |
| title_sort | hybrid microstructure based stretchable biosensors for multi physiological signal sensing |
| topic | Hybrid microstructure Stretchable electrode Stretchable biosensors Multifunctional sweat sensors Wearable electronics |
| url | http://www.sciencedirect.com/science/article/pii/S2667141724001265 |
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