Community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) clones from Paraguayan children
Introduction: Staphylococcus aureus is considered one of the most important human pathogens, and its levels of resistance to methicillin have increased even in strains isolated from people without nosocomial risk factors. Molecular analysis is essential for understanding the patterns of disseminati...
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The Journal of Infection in Developing Countries
2020-03-01
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| Series: | Journal of Infection in Developing Countries |
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| Online Access: | https://jidc.org/index.php/journal/article/view/12108 |
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| author | Fátima Rodriguez Claudia Salinas Silvina Fernandez Sol Haim Marta Mollerach Wilma Basualdo Hector Castro Beatriz Quiñónez Rocio Arguello Monica Rodriguez Lorena Grau Carmen Espínola Gladys Velázquez Gloria Samudio Gloria Gomez Ana Campuzano Juana Ortellado Patricia Almada Rosa Guillén |
| author_facet | Fátima Rodriguez Claudia Salinas Silvina Fernandez Sol Haim Marta Mollerach Wilma Basualdo Hector Castro Beatriz Quiñónez Rocio Arguello Monica Rodriguez Lorena Grau Carmen Espínola Gladys Velázquez Gloria Samudio Gloria Gomez Ana Campuzano Juana Ortellado Patricia Almada Rosa Guillén |
| author_sort | Fátima Rodriguez |
| collection | DOAJ |
| description |
Introduction: Staphylococcus aureus is considered one of the most important human pathogens, and its levels of resistance to methicillin have increased even in strains isolated from people without nosocomial risk factors. Molecular analysis is essential for understanding the patterns of dissemination. The objective of this study was to identify community-acquired methicillin-resistant S. aureus (CA-MRSA) clones that infected Paraguayan children patients in two periods of time.
Methodology: An observational, descriptive study was designed to determine the genetic variability of 115 isolates of CA-MRSA recovered from children who attended four reference centers in Paraguay between 2009-2010 and 2012-2013.
Results: The combined use of Pulsed Field Gel Electrophoresis (PFGE), Multi-Locus Sequencing Typing, Multi-Locus Variable Analysis (MLVA) and Spa typing techniques allowed the identification of two dominant clones: ST30-IV-t019 (77%) and ST5-IV-t311 (10%), and the establishment of the former as the leading cause of CA-MRSA infections in children during the study period.
Conclusions: This is the first study that provides epidemiological information as well as microbiological and molecular characteristics of CA-MRSA isolates recovered from children from Asunción and the Central Department of Paraguay.
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| format | Article |
| id | doaj-art-fde3bb49f99043d6b5617d6d2e3c8c67 |
| institution | OA Journals |
| issn | 1972-2680 |
| language | English |
| publishDate | 2020-03-01 |
| publisher | The Journal of Infection in Developing Countries |
| record_format | Article |
| series | Journal of Infection in Developing Countries |
| spelling | doaj-art-fde3bb49f99043d6b5617d6d2e3c8c672025-08-20T02:16:14ZengThe Journal of Infection in Developing CountriesJournal of Infection in Developing Countries1972-26802020-03-01140310.3855/jidc.12108Community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) clones from Paraguayan childrenFátima Rodriguez0Claudia Salinas1Silvina Fernandez2Sol Haim3Marta Mollerach4Wilma Basualdo5Hector Castro6Beatriz Quiñónez7Rocio Arguello8Monica Rodriguez9Lorena Grau10Carmen Espínola11Gladys Velázquez12Gloria Samudio13Gloria Gomez14Ana Campuzano15Juana Ortellado16Patricia Almada17Rosa Guillén18Instituto de Investigaciones en Ciencias de la Salud, Universidad Nacional de Asunción. San Lorenzo, ParaguayInstituto de Investigaciones en Ciencias de la Salud, Universidad Nacional de Asunción. San Lorenzo, ParaguayCátedra de Microbiología, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Buenos Aires, ArgentinaCátedra de Microbiología, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Buenos Aires, ArgentinaCátedra de Microbiología, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Buenos Aires, ArgentinaHospital General Pediátrico Niños de Acosta Ñú, Ministerio de Salud Pública y Bienestar Social, San Lorenzo, ParaguayHospital General Pediátrico Niños de Acosta Ñú, Ministerio de Salud Pública y Bienestar Social, San Lorenzo, ParaguayHospital General Pediátrico Niños de Acosta Ñú, Ministerio de Salud Pública y Bienestar Social, San Lorenzo, ParaguayHospital General Pediátrico Niños de Acosta Ñú, Ministerio de Salud Pública y Bienestar Social, San Lorenzo, ParaguayInstituto de Previsión Social. Asunción, ParaguayInstituto de Previsión Social. Asunción, ParaguayInstituto de Previsión Social. Asunción, ParaguayInstituto de Previsión Social. Asunción, ParaguayHospital Nacional de Itauguá, Ministerio de Salud Pública y Bienestar Social. Itauguá, ParaguayHospital Nacional de Itauguá, Ministerio de Salud Pública y Bienestar Social. Itauguá, ParaguayHospital de Clínicas, Facultad de Ciencias Médicas. Universidad Nacional de Asunción San Lorenzo, ParaguayHospital de Clínicas, Facultad de Ciencias Médicas. Universidad Nacional de Asunción San Lorenzo, ParaguayHospital de Clínicas, Facultad de Ciencias Médicas. Universidad Nacional de Asunción San Lorenzo, ParaguayInstituto de Investigaciones en Ciencias de la Salud, Universidad Nacional de Asunción. San Lorenzo, Paraguay Introduction: Staphylococcus aureus is considered one of the most important human pathogens, and its levels of resistance to methicillin have increased even in strains isolated from people without nosocomial risk factors. Molecular analysis is essential for understanding the patterns of dissemination. The objective of this study was to identify community-acquired methicillin-resistant S. aureus (CA-MRSA) clones that infected Paraguayan children patients in two periods of time. Methodology: An observational, descriptive study was designed to determine the genetic variability of 115 isolates of CA-MRSA recovered from children who attended four reference centers in Paraguay between 2009-2010 and 2012-2013. Results: The combined use of Pulsed Field Gel Electrophoresis (PFGE), Multi-Locus Sequencing Typing, Multi-Locus Variable Analysis (MLVA) and Spa typing techniques allowed the identification of two dominant clones: ST30-IV-t019 (77%) and ST5-IV-t311 (10%), and the establishment of the former as the leading cause of CA-MRSA infections in children during the study period. Conclusions: This is the first study that provides epidemiological information as well as microbiological and molecular characteristics of CA-MRSA isolates recovered from children from Asunción and the Central Department of Paraguay. https://jidc.org/index.php/journal/article/view/12108Methicillin-resistant Staphylococcus aureusMRSAchildrencommunity-associated |
| spellingShingle | Fátima Rodriguez Claudia Salinas Silvina Fernandez Sol Haim Marta Mollerach Wilma Basualdo Hector Castro Beatriz Quiñónez Rocio Arguello Monica Rodriguez Lorena Grau Carmen Espínola Gladys Velázquez Gloria Samudio Gloria Gomez Ana Campuzano Juana Ortellado Patricia Almada Rosa Guillén Community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) clones from Paraguayan children Journal of Infection in Developing Countries Methicillin-resistant Staphylococcus aureus MRSA children community-associated |
| title | Community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) clones from Paraguayan children |
| title_full | Community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) clones from Paraguayan children |
| title_fullStr | Community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) clones from Paraguayan children |
| title_full_unstemmed | Community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) clones from Paraguayan children |
| title_short | Community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) clones from Paraguayan children |
| title_sort | community associated methicillin resistant staphylococcus aureus ca mrsa clones from paraguayan children |
| topic | Methicillin-resistant Staphylococcus aureus MRSA children community-associated |
| url | https://jidc.org/index.php/journal/article/view/12108 |
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