GDF-15 Is Associated with Poor Physical Function in Prefrail Older Adults with Diabetes
Introduction. Growth differentiation factor 15 (GDF-15) has been shown to be a metabolic and appetite regulator in diabetes mellitus (DM) and obesity. We aimed to investigate (i) the association between GDF-15 and DM with and without poor physical function independent of inflammation and (ii) the pr...
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| Format: | Article |
| Language: | English |
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Wiley
2023-01-01
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| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2023/2519128 |
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| _version_ | 1832547402479828992 |
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| author | Reshma Aziz Merchant Yiong Huak Chan Gustavo Duque |
| author_facet | Reshma Aziz Merchant Yiong Huak Chan Gustavo Duque |
| author_sort | Reshma Aziz Merchant |
| collection | DOAJ |
| description | Introduction. Growth differentiation factor 15 (GDF-15) has been shown to be a metabolic and appetite regulator in diabetes mellitus (DM) and obesity. We aimed to investigate (i) the association between GDF-15 and DM with and without poor physical function independent of inflammation and (ii) the prediction model for poor physical function in prefrail older adults. Methods. A cross-sectional study of 108-prefrail participants ≥60 years recruited for multidomain interventions. Data was collected for demographics, cognition, function, frailty, nutrition, handgrip strength (HGS), short physical performance battery (SPPB), and gait speed. Serum concentrations of GDF-15, IL-6, and TNF-α were measured. GDF-15 was classified into tertiles (T1, T2, and T3), and its association was studied with DM and physical function (DM poor physical function, DM no poor physical function, no DM poor physical function, and no DM no poor physical function). Results. Compared with T1, participants in T3 were significantly older, had a lower education level, had almost three times higher prevalence of DM, slower gait speed, longer chair-stand time, and lower SPPB scores. On multivariate analysis, the odds of having both DM and poor physical performance compared to having no DM and no poor physical performance were significantly higher in GDF-15 T3 vs. GDF-15 T1 (aOR 9.7, 95% CI 1.4-67.7; p=0.021), and the odds of having DM no poor physical function compared to having no DM and no poor physical performance were significantly higher in GDF-15 T2 (aOR 12.7, 95% CI 1.1-143.7; p=0.040) independent of BMI, IL-6, TNF-α, nutrition, physical function, education, age, and gender. Conclusion. The association of GDF-15 with DM-associated poor physical function is independent of inflammation in prefrail older adults. Its causal-association link needs to be determined in longitudinal studies. |
| format | Article |
| id | doaj-art-fde2c7434fbc4cbea6321cca927d17cc |
| institution | Kabale University |
| issn | 2314-6753 |
| language | English |
| publishDate | 2023-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-fde2c7434fbc4cbea6321cca927d17cc2025-02-03T06:45:09ZengWileyJournal of Diabetes Research2314-67532023-01-01202310.1155/2023/2519128GDF-15 Is Associated with Poor Physical Function in Prefrail Older Adults with DiabetesReshma Aziz Merchant0Yiong Huak Chan1Gustavo Duque2Division of Geriatric MedicineBiostatistics UnitResearch Institute of the McGill University Health CentreIntroduction. Growth differentiation factor 15 (GDF-15) has been shown to be a metabolic and appetite regulator in diabetes mellitus (DM) and obesity. We aimed to investigate (i) the association between GDF-15 and DM with and without poor physical function independent of inflammation and (ii) the prediction model for poor physical function in prefrail older adults. Methods. A cross-sectional study of 108-prefrail participants ≥60 years recruited for multidomain interventions. Data was collected for demographics, cognition, function, frailty, nutrition, handgrip strength (HGS), short physical performance battery (SPPB), and gait speed. Serum concentrations of GDF-15, IL-6, and TNF-α were measured. GDF-15 was classified into tertiles (T1, T2, and T3), and its association was studied with DM and physical function (DM poor physical function, DM no poor physical function, no DM poor physical function, and no DM no poor physical function). Results. Compared with T1, participants in T3 were significantly older, had a lower education level, had almost three times higher prevalence of DM, slower gait speed, longer chair-stand time, and lower SPPB scores. On multivariate analysis, the odds of having both DM and poor physical performance compared to having no DM and no poor physical performance were significantly higher in GDF-15 T3 vs. GDF-15 T1 (aOR 9.7, 95% CI 1.4-67.7; p=0.021), and the odds of having DM no poor physical function compared to having no DM and no poor physical performance were significantly higher in GDF-15 T2 (aOR 12.7, 95% CI 1.1-143.7; p=0.040) independent of BMI, IL-6, TNF-α, nutrition, physical function, education, age, and gender. Conclusion. The association of GDF-15 with DM-associated poor physical function is independent of inflammation in prefrail older adults. Its causal-association link needs to be determined in longitudinal studies.http://dx.doi.org/10.1155/2023/2519128 |
| spellingShingle | Reshma Aziz Merchant Yiong Huak Chan Gustavo Duque GDF-15 Is Associated with Poor Physical Function in Prefrail Older Adults with Diabetes Journal of Diabetes Research |
| title | GDF-15 Is Associated with Poor Physical Function in Prefrail Older Adults with Diabetes |
| title_full | GDF-15 Is Associated with Poor Physical Function in Prefrail Older Adults with Diabetes |
| title_fullStr | GDF-15 Is Associated with Poor Physical Function in Prefrail Older Adults with Diabetes |
| title_full_unstemmed | GDF-15 Is Associated with Poor Physical Function in Prefrail Older Adults with Diabetes |
| title_short | GDF-15 Is Associated with Poor Physical Function in Prefrail Older Adults with Diabetes |
| title_sort | gdf 15 is associated with poor physical function in prefrail older adults with diabetes |
| url | http://dx.doi.org/10.1155/2023/2519128 |
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