One-pot synthesis and biological evaluation of N-fused imidazoles as antibacterial agents and bacterial topoisomerase inhibitors

One-pot synthesis and biological evaluation of N-fused imidazoles as antibacterial agents and bacterial topoisomerase inhibitors

A series of N-fused imidazoles related to known inhibitors of human topoisomerase IIα were rapidly synthesized by a multicomponent GBB reaction under environmentally friendly conditions with microwave heating. Two of the compounds synthesized exhibited bacteriostatic activity against methicillin-res...

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Bibliographic Details
Main Authors: Eleanor P. Bentley, Oriole W. Song, Ira Glassman, Leepakshi Johar, Cheldon A. Alcantara, Veronica L. Show, Adam R. Johnson, Hendrik Szurmant, David A. Vosburg
Format: Article
Language:English
Published: Elsevier 2025-05-01
Series:Results in Chemistry
Subjects:
Multicomponent reaction
Antibacterial agent
Topoisomerase inhibitors
Online Access:http://www.sciencedirect.com/science/article/pii/S2211715625001742
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