Systemic inflammatory indices as a non-invasive grading modality for endometriosis: a comparative study versus exploratory laparoscopy
Abstract Objective: Included evaluation of the possibility of using the systemic inflammatory indices for preoperative screening for the presence and severity of endometriosis (EM) in comparison to the findings of the exploratory laparoscopy Methods: 88 women with clinical manifestations suggestiv...
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Federação Brasileira das Sociedades de Ginecologia e Obstetrícia
2025-01-01
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| Series: | Revista Brasileira de Ginecologia e Obstetrícia |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-72032024000100261&lng=en&tlng=en |
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| author | Ahmed Sabra Ibrahim Mohammed Sabra Shreen Naguib Aboelezz Moselhy Ahmed Kasem Mohamed Zain Eldin |
| author_facet | Ahmed Sabra Ibrahim Mohammed Sabra Shreen Naguib Aboelezz Moselhy Ahmed Kasem Mohamed Zain Eldin |
| author_sort | Ahmed Sabra Ibrahim Mohammed Sabra |
| collection | DOAJ |
| description | Abstract Objective: Included evaluation of the possibility of using the systemic inflammatory indices for preoperative screening for the presence and severity of endometriosis (EM) in comparison to the findings of the exploratory laparoscopy Methods: 88 women with clinical manifestations suggestive of EM were evaluated clinically and by US and gave blood samples for estimation of serum cancer antigen-125 (CA125), platelet and total and differential leucocytic counts for calculation of inflammatory indices; the Systemic Immune-Inflammation index, the Systemic Inflammation Response Index (SIRI), the Neutrophil-Lymphocyte ratio (NLR), the Neutrophil-Monocyte ratio, the Neutrophil-Platelet ratio and the Platelet-Lymphocyte ratio. Then, patients were prepared to undergo laparoscopy for diagnosis and staging. Results: Laparoscopy detected EM lesions in 63 patients; 27 of stage I-II and 36 of stage III-IV. Positive laparoscopy showed significant relation with US grading, high serum CA125 levels, platelet and inflammatory cell counts and indices. Statistical analyses defined high SIRI and NLR as the significant predictors for positive laparoscopy and high serum CA125 and NLR as the most significant predictors for severe EM (stage III-IV) on laparoscopy Conclusion: The intimate relation between EM and inflammation was reflected systematically as high levels of blood cellular components, but indices related to neutrophil especially NLR and SIRI showed highly significant relation to the presence and severity of EM and might be used as routine, cheap and non-invasive screening test before exploratory laparoscopy to guide the decision-making. |
| format | Article |
| id | doaj-art-fdd8af1daa774787888eaae5d3bf7a94 |
| institution | Kabale University |
| issn | 0100-7203 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Federação Brasileira das Sociedades de Ginecologia e Obstetrícia |
| record_format | Article |
| series | Revista Brasileira de Ginecologia e Obstetrícia |
| spelling | doaj-art-fdd8af1daa774787888eaae5d3bf7a942025-01-21T07:36:48ZengFederação Brasileira das Sociedades de Ginecologia e ObstetríciaRevista Brasileira de Ginecologia e Obstetrícia0100-72032025-01-014610.61622/rbgo/2024rbgo84Systemic inflammatory indices as a non-invasive grading modality for endometriosis: a comparative study versus exploratory laparoscopyAhmed Sabra Ibrahim Mohammed Sabrahttps://orcid.org/0009-0005-8756-7978Shreen Naguib Aboelezz Moselhyhttps://orcid.org/0009-0003-6024-4680Ahmed Kasem Mohamed Zain Eldinhttps://orcid.org/0000-0002-5114-7227Abstract Objective: Included evaluation of the possibility of using the systemic inflammatory indices for preoperative screening for the presence and severity of endometriosis (EM) in comparison to the findings of the exploratory laparoscopy Methods: 88 women with clinical manifestations suggestive of EM were evaluated clinically and by US and gave blood samples for estimation of serum cancer antigen-125 (CA125), platelet and total and differential leucocytic counts for calculation of inflammatory indices; the Systemic Immune-Inflammation index, the Systemic Inflammation Response Index (SIRI), the Neutrophil-Lymphocyte ratio (NLR), the Neutrophil-Monocyte ratio, the Neutrophil-Platelet ratio and the Platelet-Lymphocyte ratio. Then, patients were prepared to undergo laparoscopy for diagnosis and staging. Results: Laparoscopy detected EM lesions in 63 patients; 27 of stage I-II and 36 of stage III-IV. Positive laparoscopy showed significant relation with US grading, high serum CA125 levels, platelet and inflammatory cell counts and indices. Statistical analyses defined high SIRI and NLR as the significant predictors for positive laparoscopy and high serum CA125 and NLR as the most significant predictors for severe EM (stage III-IV) on laparoscopy Conclusion: The intimate relation between EM and inflammation was reflected systematically as high levels of blood cellular components, but indices related to neutrophil especially NLR and SIRI showed highly significant relation to the presence and severity of EM and might be used as routine, cheap and non-invasive screening test before exploratory laparoscopy to guide the decision-making.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-72032024000100261&lng=en&tlng=enEndometriosisNeutrophilsCA125 antigenLaparoscopyInflammationLeukocyte countLymphocytes |
| spellingShingle | Ahmed Sabra Ibrahim Mohammed Sabra Shreen Naguib Aboelezz Moselhy Ahmed Kasem Mohamed Zain Eldin Systemic inflammatory indices as a non-invasive grading modality for endometriosis: a comparative study versus exploratory laparoscopy Revista Brasileira de Ginecologia e Obstetrícia Endometriosis Neutrophils CA125 antigen Laparoscopy Inflammation Leukocyte count Lymphocytes |
| title | Systemic inflammatory indices as a non-invasive grading modality for endometriosis: a comparative study versus exploratory laparoscopy |
| title_full | Systemic inflammatory indices as a non-invasive grading modality for endometriosis: a comparative study versus exploratory laparoscopy |
| title_fullStr | Systemic inflammatory indices as a non-invasive grading modality for endometriosis: a comparative study versus exploratory laparoscopy |
| title_full_unstemmed | Systemic inflammatory indices as a non-invasive grading modality for endometriosis: a comparative study versus exploratory laparoscopy |
| title_short | Systemic inflammatory indices as a non-invasive grading modality for endometriosis: a comparative study versus exploratory laparoscopy |
| title_sort | systemic inflammatory indices as a non invasive grading modality for endometriosis a comparative study versus exploratory laparoscopy |
| topic | Endometriosis Neutrophils CA125 antigen Laparoscopy Inflammation Leukocyte count Lymphocytes |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-72032024000100261&lng=en&tlng=en |
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