Association between Genetic Variants and Diabetes Mellitus in Iranian Populations: A Systematic Review of Observational Studies
Introduction. Diabetes mellitus as the most prevalent metabolic disease is a multifactorial disease which is influenced by environmental and genetic factors. In this systematic review, we assessed the association between genetic variants and diabetes/its complications in studies with Iranian populat...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2015/585917 |
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| author | Mehrnoosh Khodaeian Samaneh Enayati Ozra Tabatabaei-Malazy Mahsa M. Amoli |
| author_facet | Mehrnoosh Khodaeian Samaneh Enayati Ozra Tabatabaei-Malazy Mahsa M. Amoli |
| author_sort | Mehrnoosh Khodaeian |
| collection | DOAJ |
| description | Introduction. Diabetes mellitus as the most prevalent metabolic disease is a multifactorial disease which is influenced by environmental and genetic factors. In this systematic review, we assessed the association between genetic variants and diabetes/its complications in studies with Iranian populations. Methods. Google Scholar, PubMed, Scopus, and Persian web databases were systematically searched up to January 2014. The search terms were “gene,” “polymorphism,” “diabetes,” and “diabetic complications”; nephropathy, retinopathy, neuropathy, foot ulcer, and CAD (coronary artery diseases); and Persian equivalents. Animal studies, letters to editor, and in vitro studies were excluded. Results. Out of overall 3029 eligible articles, 88 articles were included. We found significant association between CTLA-4, IL-18, VDR, TAP2, IL-12, and CD4 genes and T1DM, HNFα and MODY, haptoglobin, paraoxonase, leptin, TCF7L2, calreticulin, ERα, PPAR-γ2, CXCL5, calpain-10, IRS-1 and 2, GSTM1, KCNJ11, eNOS, VDR, INSR, ACE, apoA-I, apo E, adiponectin, PTPN1, CETP, AT1R, resistin, MMP-3, BChE K, AT2R, SUMO4, IL-10, VEGF, MTHFR, and GSTM1 with T2DM or its complications. Discussion. We found some controversial results due to heterogeneity in ethnicity and genetic background. We thought genome wide association studies on large number of samples will be helpful in identifying diabetes susceptible genes as an alternative to studying individual candidate genes in Iranian populations. |
| format | Article |
| id | doaj-art-fdd00adbcb49418496682dec1e3dee59 |
| institution | Kabale University |
| issn | 2314-6745 2314-6753 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-fdd00adbcb49418496682dec1e3dee592025-02-03T05:51:04ZengWileyJournal of Diabetes Research2314-67452314-67532015-01-01201510.1155/2015/585917585917Association between Genetic Variants and Diabetes Mellitus in Iranian Populations: A Systematic Review of Observational StudiesMehrnoosh Khodaeian0Samaneh Enayati1Ozra Tabatabaei-Malazy2Mahsa M. Amoli3Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, IranEndocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, IranDiabetes Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, IranEndocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, IranIntroduction. Diabetes mellitus as the most prevalent metabolic disease is a multifactorial disease which is influenced by environmental and genetic factors. In this systematic review, we assessed the association between genetic variants and diabetes/its complications in studies with Iranian populations. Methods. Google Scholar, PubMed, Scopus, and Persian web databases were systematically searched up to January 2014. The search terms were “gene,” “polymorphism,” “diabetes,” and “diabetic complications”; nephropathy, retinopathy, neuropathy, foot ulcer, and CAD (coronary artery diseases); and Persian equivalents. Animal studies, letters to editor, and in vitro studies were excluded. Results. Out of overall 3029 eligible articles, 88 articles were included. We found significant association between CTLA-4, IL-18, VDR, TAP2, IL-12, and CD4 genes and T1DM, HNFα and MODY, haptoglobin, paraoxonase, leptin, TCF7L2, calreticulin, ERα, PPAR-γ2, CXCL5, calpain-10, IRS-1 and 2, GSTM1, KCNJ11, eNOS, VDR, INSR, ACE, apoA-I, apo E, adiponectin, PTPN1, CETP, AT1R, resistin, MMP-3, BChE K, AT2R, SUMO4, IL-10, VEGF, MTHFR, and GSTM1 with T2DM or its complications. Discussion. We found some controversial results due to heterogeneity in ethnicity and genetic background. We thought genome wide association studies on large number of samples will be helpful in identifying diabetes susceptible genes as an alternative to studying individual candidate genes in Iranian populations.http://dx.doi.org/10.1155/2015/585917 |
| spellingShingle | Mehrnoosh Khodaeian Samaneh Enayati Ozra Tabatabaei-Malazy Mahsa M. Amoli Association between Genetic Variants and Diabetes Mellitus in Iranian Populations: A Systematic Review of Observational Studies Journal of Diabetes Research |
| title | Association between Genetic Variants and Diabetes Mellitus in Iranian Populations: A Systematic Review of Observational Studies |
| title_full | Association between Genetic Variants and Diabetes Mellitus in Iranian Populations: A Systematic Review of Observational Studies |
| title_fullStr | Association between Genetic Variants and Diabetes Mellitus in Iranian Populations: A Systematic Review of Observational Studies |
| title_full_unstemmed | Association between Genetic Variants and Diabetes Mellitus in Iranian Populations: A Systematic Review of Observational Studies |
| title_short | Association between Genetic Variants and Diabetes Mellitus in Iranian Populations: A Systematic Review of Observational Studies |
| title_sort | association between genetic variants and diabetes mellitus in iranian populations a systematic review of observational studies |
| url | http://dx.doi.org/10.1155/2015/585917 |
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