Biological activity produced by ruthenium chloride on perfusion pressure, left ventricular pressure and heart failure using an isolated rat heart model
Background: Several drugs have been used to treat heart failure, including digoxin, spironolactone, captopril, and valsartan; however, some of these drugs can produce different secondary effects. Aim and Objectives: The aim of this investigation was to evaluate the biological activity of ruthenium...
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| Format: | Article |
| Language: | English |
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Krishna Vishwa Vidyapeeth (Deemed to be University), Karad
2024-07-01
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| Series: | Journal of Krishna Institute of Medical Sciences University |
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| Online Access: | https://www.jkimsu.com/jkimsu-vol13no3/JKIMSU,%20Vol.%2013,%20No.%203,%20July-September%202024%20Page%2037-45.pdf |
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| author | Figueroa-Valverde Lauro Rosas-Nexticapa Marcela Alvarez-Ramirez Magdalena Lopez-Ramos Maria Aguilar-Sanchez Emilio Mateu-Armand Virginia |
| author_facet | Figueroa-Valverde Lauro Rosas-Nexticapa Marcela Alvarez-Ramirez Magdalena Lopez-Ramos Maria Aguilar-Sanchez Emilio Mateu-Armand Virginia |
| author_sort | Figueroa-Valverde Lauro |
| collection | DOAJ |
| description | Background: Several drugs have been used to treat heart failure, including digoxin, spironolactone, captopril, and valsartan; however, some of these drugs can produce different secondary effects. Aim and Objectives: The aim of this
investigation was to evaluate the biological activity of ruthenium chloride on perfusion pressure, left ventricular pressure and heart failure. Material and Methods: Effects produced by ruthenium chloride (0.001 to 100 nM) on
perfusion pressure was evaluated using an isolated rat heart model. Besides, the biological activity of ruthenium chloride (1 to 100 nM) on Left Ventricular Pressure (LVP) was determined in the absence or presence of nifedipine,
indomethacin, prazosin, and WB-4101 at a dose of 1 nM. Finally, biological activity of ruthenium chloride (1 to 100 nM) against heart failure was evaluated using an ischemia/reperfusion injury model. Results: The results showed that ruthenium chloride increased the perfusion pressure from 1 to 100 nM; ruthenium chloride increased LVP in a dose-dependent manner, whose effect was inhibited by prazosin and WB-4101; and the ruthenium derivative significantly decreased the infarct area (p = 0.05) compared with the control conditions. Conclusion: These data suggest that ruthenium chloride may act as α -adrenoreceptor activator and could be a good agent to treat heart failure. |
| format | Article |
| id | doaj-art-fdca20cb135a49a8bfae317191e1ff75 |
| institution | Kabale University |
| issn | 2231-4261 |
| language | English |
| publishDate | 2024-07-01 |
| publisher | Krishna Vishwa Vidyapeeth (Deemed to be University), Karad |
| record_format | Article |
| series | Journal of Krishna Institute of Medical Sciences University |
| spelling | doaj-art-fdca20cb135a49a8bfae317191e1ff752025-02-02T02:36:57ZengKrishna Vishwa Vidyapeeth (Deemed to be University), KaradJournal of Krishna Institute of Medical Sciences University2231-42612024-07-011333745Biological activity produced by ruthenium chloride on perfusion pressure, left ventricular pressure and heart failure using an isolated rat heart modelFigueroa-Valverde Lauro0Rosas-Nexticapa Marcela 1Alvarez-Ramirez Magdalena2Lopez-Ramos Maria3Aguilar-Sanchez Emilio4Mateu-Armand Virginia5Laboratory of Pharmaco-Chemistry, Faculty of Chemical Biological Sciences, University Autonomous of Campeche, Av. Humberto Lanz Cárdenas S/N, Colonia Ex Hacienda Kalá, C.P. 24085, Campeche, Camp., MexicoFaculty of Nutrition, University Veracruzana, Médicos y Odontologos s/n C.P. 91010, Unidad del Bosque Xalapa Veracruz, MexicoFaculty of Nutrition, University Veracruzana, Médicos y Odontologos s/n C.P. 91010, Unidad del Bosque Xalapa Veracruz, MexicoLaboratory of Pharmaco-Chemistry, Faculty of Chemical Biological Sciences, University Autonomous of Campeche, Av. Humberto Lanz Cárdenas S/N, Colonia Ex Hacienda Kalá, C.P. 24085, Campeche, Camp., MexicoFaculty of Medicine, University Veracruzana, Médicos y Odontologos s/n C.P. 91010, Unidad del Bosque Xalapa Veracruz, MexicoFaculty of Nutrition, University Veracruzana, Médicos y Odontologos s/n C.P. 91010, Unidad del Bosque Xalapa Veracruz, MexicoBackground: Several drugs have been used to treat heart failure, including digoxin, spironolactone, captopril, and valsartan; however, some of these drugs can produce different secondary effects. Aim and Objectives: The aim of this investigation was to evaluate the biological activity of ruthenium chloride on perfusion pressure, left ventricular pressure and heart failure. Material and Methods: Effects produced by ruthenium chloride (0.001 to 100 nM) on perfusion pressure was evaluated using an isolated rat heart model. Besides, the biological activity of ruthenium chloride (1 to 100 nM) on Left Ventricular Pressure (LVP) was determined in the absence or presence of nifedipine, indomethacin, prazosin, and WB-4101 at a dose of 1 nM. Finally, biological activity of ruthenium chloride (1 to 100 nM) against heart failure was evaluated using an ischemia/reperfusion injury model. Results: The results showed that ruthenium chloride increased the perfusion pressure from 1 to 100 nM; ruthenium chloride increased LVP in a dose-dependent manner, whose effect was inhibited by prazosin and WB-4101; and the ruthenium derivative significantly decreased the infarct area (p = 0.05) compared with the control conditions. Conclusion: These data suggest that ruthenium chloride may act as α -adrenoreceptor activator and could be a good agent to treat heart failure.https://www.jkimsu.com/jkimsu-vol13no3/JKIMSU,%20Vol.%2013,%20No.%203,%20July-September%202024%20Page%2037-45.pdfruthenium chlorideheart failureα -adrenoreceptorreceptor |
| spellingShingle | Figueroa-Valverde Lauro Rosas-Nexticapa Marcela Alvarez-Ramirez Magdalena Lopez-Ramos Maria Aguilar-Sanchez Emilio Mateu-Armand Virginia Biological activity produced by ruthenium chloride on perfusion pressure, left ventricular pressure and heart failure using an isolated rat heart model Journal of Krishna Institute of Medical Sciences University ruthenium chloride heart failure α -adrenoreceptor receptor |
| title | Biological activity produced by ruthenium chloride on perfusion pressure, left ventricular pressure and heart failure using an isolated rat heart model |
| title_full | Biological activity produced by ruthenium chloride on perfusion pressure, left ventricular pressure and heart failure using an isolated rat heart model |
| title_fullStr | Biological activity produced by ruthenium chloride on perfusion pressure, left ventricular pressure and heart failure using an isolated rat heart model |
| title_full_unstemmed | Biological activity produced by ruthenium chloride on perfusion pressure, left ventricular pressure and heart failure using an isolated rat heart model |
| title_short | Biological activity produced by ruthenium chloride on perfusion pressure, left ventricular pressure and heart failure using an isolated rat heart model |
| title_sort | biological activity produced by ruthenium chloride on perfusion pressure left ventricular pressure and heart failure using an isolated rat heart model |
| topic | ruthenium chloride heart failure α -adrenoreceptor receptor |
| url | https://www.jkimsu.com/jkimsu-vol13no3/JKIMSU,%20Vol.%2013,%20No.%203,%20July-September%202024%20Page%2037-45.pdf |
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