Delineating Novel Signature Patterns of Altered Gene Expression in Schizophrenia Using Gene Microarrays
Schizophrenia is a complex and devastating brain disorder that affects 1% of the population and ranks as one of the most costly disorders to afflict humans. This disorder typically has its clinical onset in late adolescence or early adulthood, presenting as a constellation of delusions and hallucina...
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| Format: | Article |
| Language: | English |
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Wiley
2001-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1100/tsw.2001.17 |
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| author | Karoly Mirnics Frank A. Middleton David A. Lewis Pat Levitt |
| author_facet | Karoly Mirnics Frank A. Middleton David A. Lewis Pat Levitt |
| author_sort | Karoly Mirnics |
| collection | DOAJ |
| description | Schizophrenia is a complex and devastating brain disorder that affects 1% of the population and ranks as one of the most costly disorders to afflict humans. This disorder typically has its clinical onset in late adolescence or early adulthood, presenting as a constellation of delusions and hallucinations (positive symptoms); decreased motivation, emotional expression, and social interactions (negative symptoms); and impaired learning and memory (cognitive symptoms). The etiology of schizophrenia is unknown, but appears to be multifaceted, with genetic and epigenetic developmental factors all implicated. A convergence of observations from clinical, neuroimaging, and anatomical studies has implicated the dorsal prefrontal cortex as a major locus of alterations in schizophrenia. |
| format | Article |
| id | doaj-art-fdc810103b4d437aab37e0f058578c6c |
| institution | Kabale University |
| issn | 1537-744X |
| language | English |
| publishDate | 2001-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-fdc810103b4d437aab37e0f058578c6c2025-02-03T01:31:31ZengWileyThe Scientific World Journal1537-744X2001-01-01111411610.1100/tsw.2001.17Delineating Novel Signature Patterns of Altered Gene Expression in Schizophrenia Using Gene MicroarraysKaroly Mirnics0Frank A. Middleton1David A. Lewis2Pat Levitt3Department of neurobiology, University of Pittsburgh School of Medicine, PA 15261, USADepartment of neurobiology, University of Pittsburgh School of Medicine, PA 15261, USADepartment of neurobiology, University of Pittsburgh School of Medicine, PA 15261, USADepartment of neurobiology, University of Pittsburgh School of Medicine, PA 15261, USASchizophrenia is a complex and devastating brain disorder that affects 1% of the population and ranks as one of the most costly disorders to afflict humans. This disorder typically has its clinical onset in late adolescence or early adulthood, presenting as a constellation of delusions and hallucinations (positive symptoms); decreased motivation, emotional expression, and social interactions (negative symptoms); and impaired learning and memory (cognitive symptoms). The etiology of schizophrenia is unknown, but appears to be multifaceted, with genetic and epigenetic developmental factors all implicated. A convergence of observations from clinical, neuroimaging, and anatomical studies has implicated the dorsal prefrontal cortex as a major locus of alterations in schizophrenia.http://dx.doi.org/10.1100/tsw.2001.17 |
| spellingShingle | Karoly Mirnics Frank A. Middleton David A. Lewis Pat Levitt Delineating Novel Signature Patterns of Altered Gene Expression in Schizophrenia Using Gene Microarrays The Scientific World Journal |
| title | Delineating Novel Signature Patterns of Altered Gene Expression in Schizophrenia Using Gene Microarrays |
| title_full | Delineating Novel Signature Patterns of Altered Gene Expression in Schizophrenia Using Gene Microarrays |
| title_fullStr | Delineating Novel Signature Patterns of Altered Gene Expression in Schizophrenia Using Gene Microarrays |
| title_full_unstemmed | Delineating Novel Signature Patterns of Altered Gene Expression in Schizophrenia Using Gene Microarrays |
| title_short | Delineating Novel Signature Patterns of Altered Gene Expression in Schizophrenia Using Gene Microarrays |
| title_sort | delineating novel signature patterns of altered gene expression in schizophrenia using gene microarrays |
| url | http://dx.doi.org/10.1100/tsw.2001.17 |
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