Immune Checkpoint Inhibitor Therapy for Bone Metastases: Specific Microenvironment and Current Situation
The treatment of bone metastases is a thorny issue. Immunotherapy may be one of the few hopes for patients with unresectable bone metastases. Immune checkpoint inhibitors are the most commonly used immunotherapy drugs currently. In this review, the characteristics and interaction of bone metastases...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2021-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2021/8970173 |
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| _version_ | 1832553721828999168 |
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| author | Chang Liu Miao Wang Changli Xu Bo Li Juxiang Chen Jianchun Chen Zhiwei Wang |
| author_facet | Chang Liu Miao Wang Changli Xu Bo Li Juxiang Chen Jianchun Chen Zhiwei Wang |
| author_sort | Chang Liu |
| collection | DOAJ |
| description | The treatment of bone metastases is a thorny issue. Immunotherapy may be one of the few hopes for patients with unresectable bone metastases. Immune checkpoint inhibitors are the most commonly used immunotherapy drugs currently. In this review, the characteristics and interaction of bone metastases and their immune microenvironment were systematically discussed, and the relevant research progress of the immunological mechanism of tumor bone metastasis was reviewed. On this basis, we expounded the clinical application of immune checkpoint inhibitors for bone metastasis of common tumors, including non-small-cell lung cancer, renal cell carcinoma, prostate cancer, melanoma, and breast cancer. Then, the deficiencies and limitations in current researches were summarized. In-depth basic research on bone metastases and optimization of clinical treatment is needed. |
| format | Article |
| id | doaj-art-fdc71b1096b64671947401962a32e000 |
| institution | Kabale University |
| issn | 2314-7156 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-fdc71b1096b64671947401962a32e0002025-02-03T05:53:26ZengWileyJournal of Immunology Research2314-71562021-01-01202110.1155/2021/8970173Immune Checkpoint Inhibitor Therapy for Bone Metastases: Specific Microenvironment and Current SituationChang Liu0Miao Wang1Changli Xu2Bo Li3Juxiang Chen4Jianchun Chen5Zhiwei Wang6Department of OrthopedicsDepartment of OrthopedicsDepartment of OrthopedicsDepartment of OrthopedicsDepartment of NeurosurgeryDepartment of NeurosurgeryDepartment of OrthopedicsThe treatment of bone metastases is a thorny issue. Immunotherapy may be one of the few hopes for patients with unresectable bone metastases. Immune checkpoint inhibitors are the most commonly used immunotherapy drugs currently. In this review, the characteristics and interaction of bone metastases and their immune microenvironment were systematically discussed, and the relevant research progress of the immunological mechanism of tumor bone metastasis was reviewed. On this basis, we expounded the clinical application of immune checkpoint inhibitors for bone metastasis of common tumors, including non-small-cell lung cancer, renal cell carcinoma, prostate cancer, melanoma, and breast cancer. Then, the deficiencies and limitations in current researches were summarized. In-depth basic research on bone metastases and optimization of clinical treatment is needed.http://dx.doi.org/10.1155/2021/8970173 |
| spellingShingle | Chang Liu Miao Wang Changli Xu Bo Li Juxiang Chen Jianchun Chen Zhiwei Wang Immune Checkpoint Inhibitor Therapy for Bone Metastases: Specific Microenvironment and Current Situation Journal of Immunology Research |
| title | Immune Checkpoint Inhibitor Therapy for Bone Metastases: Specific Microenvironment and Current Situation |
| title_full | Immune Checkpoint Inhibitor Therapy for Bone Metastases: Specific Microenvironment and Current Situation |
| title_fullStr | Immune Checkpoint Inhibitor Therapy for Bone Metastases: Specific Microenvironment and Current Situation |
| title_full_unstemmed | Immune Checkpoint Inhibitor Therapy for Bone Metastases: Specific Microenvironment and Current Situation |
| title_short | Immune Checkpoint Inhibitor Therapy for Bone Metastases: Specific Microenvironment and Current Situation |
| title_sort | immune checkpoint inhibitor therapy for bone metastases specific microenvironment and current situation |
| url | http://dx.doi.org/10.1155/2021/8970173 |
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