Association between Nonalcoholic Fatty Liver Disease and Endocrinopathies: Clinical Implications
Nonalcoholic fatty liver disease (NAFLD) has a rising prevalence worldwide. Its potential for evolution towards liver cirrhosis and hepatocellular carcinoma, as well as associations with extrahepatic manifestations, represents a double burden for patients and physicians alike. Recently, there has be...
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | Canadian Journal of Gastroenterology and Hepatology |
| Online Access: | http://dx.doi.org/10.1155/2021/6678142 |
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| author | Ana-Maria Singeap Carol Stanciu Laura Huiban Cristina Maria Muzica Tudor Cuciureanu Irina Girleanu Stefan Chiriac Sebastian Zenovia Robert Nastasa Catalin Sfarti Camelia Cojocariu Anca Trifan |
| author_facet | Ana-Maria Singeap Carol Stanciu Laura Huiban Cristina Maria Muzica Tudor Cuciureanu Irina Girleanu Stefan Chiriac Sebastian Zenovia Robert Nastasa Catalin Sfarti Camelia Cojocariu Anca Trifan |
| author_sort | Ana-Maria Singeap |
| collection | DOAJ |
| description | Nonalcoholic fatty liver disease (NAFLD) has a rising prevalence worldwide. Its potential for evolution towards liver cirrhosis and hepatocellular carcinoma, as well as associations with extrahepatic manifestations, represents a double burden for patients and physicians alike. Recently, there has been increasing evidence of the association between NAFLD and a number of endocrinopathies, such as hypothyroidism, polycystic ovarian syndrome (PCOS), hypopituitarism, growth hormone deficiency (GHD), hypogonadism, and hypercortisolism. Definite correlations are supported by clear evidence so far, but further studies are needed in order to completely clarify the pathogenic mechanisms and, especially, to identify therapeutic implications. In this review, we present the main relationships between NAFLD and endocrinopathies, emphasizing the reciprocal causality, evolutive interconnections, and current clinical scenarios of presentations of which the clinicians should be aware. |
| format | Article |
| id | doaj-art-fdc429fcfa484c128baa26f7b13256df |
| institution | Kabale University |
| issn | 2291-2789 2291-2797 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Journal of Gastroenterology and Hepatology |
| spelling | doaj-art-fdc429fcfa484c128baa26f7b13256df2025-02-03T06:43:54ZengWileyCanadian Journal of Gastroenterology and Hepatology2291-27892291-27972021-01-01202110.1155/2021/66781426678142Association between Nonalcoholic Fatty Liver Disease and Endocrinopathies: Clinical ImplicationsAna-Maria Singeap0Carol Stanciu1Laura Huiban2Cristina Maria Muzica3Tudor Cuciureanu4Irina Girleanu5Stefan Chiriac6Sebastian Zenovia7Robert Nastasa8Catalin Sfarti9Camelia Cojocariu10Anca Trifan11Department of Gastroenterology, “Grigore T. Popa” University of Medicine and Pharmacy, Iasi 700115, RomaniaInstitute of Gastroenterology and Hepatology, “St. Spiridon” Emergency Hospital, Iasi 700111, RomaniaDepartment of Gastroenterology, “Grigore T. Popa” University of Medicine and Pharmacy, Iasi 700115, RomaniaDepartment of Gastroenterology, “Grigore T. Popa” University of Medicine and Pharmacy, Iasi 700115, RomaniaDepartment of Gastroenterology, “Grigore T. Popa” University of Medicine and Pharmacy, Iasi 700115, RomaniaDepartment of Gastroenterology, “Grigore T. Popa” University of Medicine and Pharmacy, Iasi 700115, RomaniaDepartment of Gastroenterology, “Grigore T. Popa” University of Medicine and Pharmacy, Iasi 700115, RomaniaDepartment of Gastroenterology, “Grigore T. Popa” University of Medicine and Pharmacy, Iasi 700115, RomaniaDepartment of Gastroenterology, “Grigore T. Popa” University of Medicine and Pharmacy, Iasi 700115, RomaniaDepartment of Gastroenterology, “Grigore T. Popa” University of Medicine and Pharmacy, Iasi 700115, RomaniaDepartment of Gastroenterology, “Grigore T. Popa” University of Medicine and Pharmacy, Iasi 700115, RomaniaDepartment of Gastroenterology, “Grigore T. Popa” University of Medicine and Pharmacy, Iasi 700115, RomaniaNonalcoholic fatty liver disease (NAFLD) has a rising prevalence worldwide. Its potential for evolution towards liver cirrhosis and hepatocellular carcinoma, as well as associations with extrahepatic manifestations, represents a double burden for patients and physicians alike. Recently, there has been increasing evidence of the association between NAFLD and a number of endocrinopathies, such as hypothyroidism, polycystic ovarian syndrome (PCOS), hypopituitarism, growth hormone deficiency (GHD), hypogonadism, and hypercortisolism. Definite correlations are supported by clear evidence so far, but further studies are needed in order to completely clarify the pathogenic mechanisms and, especially, to identify therapeutic implications. In this review, we present the main relationships between NAFLD and endocrinopathies, emphasizing the reciprocal causality, evolutive interconnections, and current clinical scenarios of presentations of which the clinicians should be aware.http://dx.doi.org/10.1155/2021/6678142 |
| spellingShingle | Ana-Maria Singeap Carol Stanciu Laura Huiban Cristina Maria Muzica Tudor Cuciureanu Irina Girleanu Stefan Chiriac Sebastian Zenovia Robert Nastasa Catalin Sfarti Camelia Cojocariu Anca Trifan Association between Nonalcoholic Fatty Liver Disease and Endocrinopathies: Clinical Implications Canadian Journal of Gastroenterology and Hepatology |
| title | Association between Nonalcoholic Fatty Liver Disease and Endocrinopathies: Clinical Implications |
| title_full | Association between Nonalcoholic Fatty Liver Disease and Endocrinopathies: Clinical Implications |
| title_fullStr | Association between Nonalcoholic Fatty Liver Disease and Endocrinopathies: Clinical Implications |
| title_full_unstemmed | Association between Nonalcoholic Fatty Liver Disease and Endocrinopathies: Clinical Implications |
| title_short | Association between Nonalcoholic Fatty Liver Disease and Endocrinopathies: Clinical Implications |
| title_sort | association between nonalcoholic fatty liver disease and endocrinopathies clinical implications |
| url | http://dx.doi.org/10.1155/2021/6678142 |
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