Research hotspots and frontiers in the tumor microenvironment of colorectal cancer: a bibliometric study from 2014 to 2024
BackgroundColorectal cancer (CRC) is the second leading cause of cancer deaths globally, which poses a heavy burden on our healthcare and economy. In recent years, increasing researches suggest that the tumor microenvironment (TME) influences cancer onset, progression, metastasis, and treatment. Thi...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2025-02-01
|
| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2025.1525280/full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832540365062668288 |
|---|---|
| author | Xinran He Tingyi Xie Li Shi Xuyi Kuang Lei Li Xingyu Shang Bo Fu |
| author_facet | Xinran He Tingyi Xie Li Shi Xuyi Kuang Lei Li Xingyu Shang Bo Fu |
| author_sort | Xinran He |
| collection | DOAJ |
| description | BackgroundColorectal cancer (CRC) is the second leading cause of cancer deaths globally, which poses a heavy burden on our healthcare and economy. In recent years, increasing researches suggest that the tumor microenvironment (TME) influences cancer onset, progression, metastasis, and treatment. This has become a popular direction for researching and attacking cancer. However, to date, there is no bibliometric analysis of colorectal cancer and tumor microenvironment from 2014 to 2024. This study aims to provide a comprehensive picture of the current research status, hotspots, and future trends in this field from a bibliometric perspective.MethodsIn this study, the publications about colorectal cancer and tumor microenvironment from 2014 to 2024 were searched based on the Web of Science Core Collection database. Then we analyzed and visualized the data using CiteSpace, VOSviewer, bibliometrix package, and Microsoft Excel 2019.ResultsA total of 748 publications were included in our study, and the number of publications entered a period of rapid growth after 2019. China and the United States are the major research and collaboration centers in this field. Elkord, Eyad is the most prolific author, and Frontiers in Immunology is the journal that published the most papers on the TME of CRC. In addition, keyword and cluster analysis showed that immune checkpoint inhibitors, cancer-associated fibroblasts, macrophage polarization, intestinal microbiota, colorectal cancer liver metastasis, drug resistance, scRNA-seq, etc. may be the research hotspots and trends in this field.ConclusionsColorectal cancer and tumor microenvironment research is in the developmental stage, and strengthening international cooperation can help to drive this field forward. The main components and signaling in TME, CRC immunotherapy, colorectal cancer liver metastasis, and new research techniques are the hot research directions in this domain. Our findings will provide scholars with an up-to-date perspective on the current state of research, hotspots, and future trends in this field. |
| format | Article |
| id | doaj-art-fdbe8d610dd545bb9021e2b25cc1250c |
| institution | Kabale University |
| issn | 2234-943X |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj-art-fdbe8d610dd545bb9021e2b25cc1250c2025-02-05T05:17:39ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2025-02-011510.3389/fonc.2025.15252801525280Research hotspots and frontiers in the tumor microenvironment of colorectal cancer: a bibliometric study from 2014 to 2024Xinran He0Tingyi Xie1Li Shi2Xuyi Kuang3Lei Li4Xingyu Shang5Bo Fu6The Fourth Clinical Medical College of Guangzhou University of Chinese Medicine, Shenzhen, Guangdong, ChinaThe Fourth Clinical Medical College of Guangzhou University of Chinese Medicine, Shenzhen, Guangdong, ChinaThe Fourth Clinical Medical College of Guangzhou University of Chinese Medicine, Shenzhen, Guangdong, ChinaThe Fourth Clinical Medical College of Guangzhou University of Chinese Medicine, Shenzhen, Guangdong, ChinaThe Fourth Clinical Medical College of Guangzhou University of Chinese Medicine, Shenzhen, Guangdong, ChinaThe Fourth Clinical Medical College of Guangzhou University of Chinese Medicine, Shenzhen, Guangdong, ChinaDepartment of Nephrology, Shenzhen Traditional Chinese Medicine Hospital, Shenzhen, ChinaBackgroundColorectal cancer (CRC) is the second leading cause of cancer deaths globally, which poses a heavy burden on our healthcare and economy. In recent years, increasing researches suggest that the tumor microenvironment (TME) influences cancer onset, progression, metastasis, and treatment. This has become a popular direction for researching and attacking cancer. However, to date, there is no bibliometric analysis of colorectal cancer and tumor microenvironment from 2014 to 2024. This study aims to provide a comprehensive picture of the current research status, hotspots, and future trends in this field from a bibliometric perspective.MethodsIn this study, the publications about colorectal cancer and tumor microenvironment from 2014 to 2024 were searched based on the Web of Science Core Collection database. Then we analyzed and visualized the data using CiteSpace, VOSviewer, bibliometrix package, and Microsoft Excel 2019.ResultsA total of 748 publications were included in our study, and the number of publications entered a period of rapid growth after 2019. China and the United States are the major research and collaboration centers in this field. Elkord, Eyad is the most prolific author, and Frontiers in Immunology is the journal that published the most papers on the TME of CRC. In addition, keyword and cluster analysis showed that immune checkpoint inhibitors, cancer-associated fibroblasts, macrophage polarization, intestinal microbiota, colorectal cancer liver metastasis, drug resistance, scRNA-seq, etc. may be the research hotspots and trends in this field.ConclusionsColorectal cancer and tumor microenvironment research is in the developmental stage, and strengthening international cooperation can help to drive this field forward. The main components and signaling in TME, CRC immunotherapy, colorectal cancer liver metastasis, and new research techniques are the hot research directions in this domain. Our findings will provide scholars with an up-to-date perspective on the current state of research, hotspots, and future trends in this field.https://www.frontiersin.org/articles/10.3389/fonc.2025.1525280/fullcolorectal cancerthe tumor microenvironmentbibliometric analysishotspotsWoSCC |
| spellingShingle | Xinran He Tingyi Xie Li Shi Xuyi Kuang Lei Li Xingyu Shang Bo Fu Research hotspots and frontiers in the tumor microenvironment of colorectal cancer: a bibliometric study from 2014 to 2024 Frontiers in Oncology colorectal cancer the tumor microenvironment bibliometric analysis hotspots WoSCC |
| title | Research hotspots and frontiers in the tumor microenvironment of colorectal cancer: a bibliometric study from 2014 to 2024 |
| title_full | Research hotspots and frontiers in the tumor microenvironment of colorectal cancer: a bibliometric study from 2014 to 2024 |
| title_fullStr | Research hotspots and frontiers in the tumor microenvironment of colorectal cancer: a bibliometric study from 2014 to 2024 |
| title_full_unstemmed | Research hotspots and frontiers in the tumor microenvironment of colorectal cancer: a bibliometric study from 2014 to 2024 |
| title_short | Research hotspots and frontiers in the tumor microenvironment of colorectal cancer: a bibliometric study from 2014 to 2024 |
| title_sort | research hotspots and frontiers in the tumor microenvironment of colorectal cancer a bibliometric study from 2014 to 2024 |
| topic | colorectal cancer the tumor microenvironment bibliometric analysis hotspots WoSCC |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2025.1525280/full |
| work_keys_str_mv | AT xinranhe researchhotspotsandfrontiersinthetumormicroenvironmentofcolorectalcancerabibliometricstudyfrom2014to2024 AT tingyixie researchhotspotsandfrontiersinthetumormicroenvironmentofcolorectalcancerabibliometricstudyfrom2014to2024 AT lishi researchhotspotsandfrontiersinthetumormicroenvironmentofcolorectalcancerabibliometricstudyfrom2014to2024 AT xuyikuang researchhotspotsandfrontiersinthetumormicroenvironmentofcolorectalcancerabibliometricstudyfrom2014to2024 AT leili researchhotspotsandfrontiersinthetumormicroenvironmentofcolorectalcancerabibliometricstudyfrom2014to2024 AT xingyushang researchhotspotsandfrontiersinthetumormicroenvironmentofcolorectalcancerabibliometricstudyfrom2014to2024 AT bofu researchhotspotsandfrontiersinthetumormicroenvironmentofcolorectalcancerabibliometricstudyfrom2014to2024 |