SAE1 promotes tumor cell malignancy via SUMOylation and liquid–liquid phase separation facilitated nuclear export of p27

SAE1 promotes tumor cell malignancy via SUMOylation and liquid–liquid phase separation facilitated nuclear export of p27

Most cancers are currently incurable, partly due to abnormal post-translational modifications (PTMs). In this study, we initially used multiple myeloma (MM) as a working model and found that SUMOylation activating enzyme subunit 1 (SAE1) promotes the malignancy of MM. Through proteome microarray ana...

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Bibliographic Details
Main Authors: Ling Wang, Jie Min, Jinjun Qian, Xiaofang Huang, Xichao Yu, Yuhao Cao, Shanliang Sun, Mengying Ke, Xinyu Lv, Wenfeng Su, Mengjie Guo, Nianguang Li, Shiqian Qi, Hongming Huang, Chunyan Gu, Ye Yang
Format: Article
Language:English
Published: Elsevier 2025-04-01
Series:Acta Pharmaceutica Sinica B
Subjects:
Cancer
Multiple myeloma
Post-translational modifications
SAE1
SUMOylation
p27
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383525000656
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