The Potential Role of Regulatory B Cells in Idiopathic Membranous Nephropathy
Regulatory B cells (Breg) are widely regarded as immunomodulatory cells which play an immunosuppressive role. Breg inhibits pathological autoimmune response by secreting interleukin-10 (IL-10), transforming growth factor-β (TGF-β), and adenosine and through other ways to prevent T cells and other im...
Saved in:
| Main Authors: | , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2020-01-01
|
| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2020/7638365 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832560360510455808 |
|---|---|
| author | Zhaocheng Dong Zhiyuan Liu Haoran Dai Wenbin Liu Zhendong Feng Qihan Zhao Yu Gao Fei Liu Na Zhang Xuan Dong Xiaoshan Zhou Jieli Du Guangrui Huang Xuefei Tian Baoli Liu |
| author_facet | Zhaocheng Dong Zhiyuan Liu Haoran Dai Wenbin Liu Zhendong Feng Qihan Zhao Yu Gao Fei Liu Na Zhang Xuan Dong Xiaoshan Zhou Jieli Du Guangrui Huang Xuefei Tian Baoli Liu |
| author_sort | Zhaocheng Dong |
| collection | DOAJ |
| description | Regulatory B cells (Breg) are widely regarded as immunomodulatory cells which play an immunosuppressive role. Breg inhibits pathological autoimmune response by secreting interleukin-10 (IL-10), transforming growth factor-β (TGF-β), and adenosine and through other ways to prevent T cells and other immune cells from expanding. Recent studies have shown that different inflammatory environments induce different types of Breg cells, and these different Breg cells have different functions. For example, Br1 cells can secrete IgG4 to block autoantigens. Idiopathic membranous nephropathy (IMN) is an autoimmune disease in which the humoral immune response is dominant and the cellular immune response is impaired. However, only a handful of studies have been done on the role of Bregs in this regard. In this review, we provide a brief overview of the types and functions of Breg found in human body, as well as the abnormal pathological and immunological phenomena in IMN, and propose the hypothesis that Breg is activated in IMN patients and the proportion of Br1 can be increased. Our review aims at highlighting the correlation between Breg and IMN and proposes potential mechanisms, which can provide a new direction for the discovery of the pathogenesis of IMN, thus providing a new strategy for the prevention and early treatment of IMN. |
| format | Article |
| id | doaj-art-fd94772b40144c5899e5687bb86c4740 |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-fd94772b40144c5899e5687bb86c47402025-02-03T01:27:56ZengWileyJournal of Immunology Research2314-88612314-71562020-01-01202010.1155/2020/76383657638365The Potential Role of Regulatory B Cells in Idiopathic Membranous NephropathyZhaocheng Dong0Zhiyuan Liu1Haoran Dai2Wenbin Liu3Zhendong Feng4Qihan Zhao5Yu Gao6Fei Liu7Na Zhang8Xuan Dong9Xiaoshan Zhou10Jieli Du11Guangrui Huang12Xuefei Tian13Baoli Liu14Beijing University of Chinese Medicine, No. 11, North Third Ring Road, Chaoyang District, Beijing 100029, ChinaShandong First Medical University, No. 619 Changcheng Road, Tai’an City, Shandong 271016, ChinaShunyi Branch, Beijing Traditional Chinese Medicine Hospital, Station East 5, Shunyi District, Beijing 101300, ChinaBeijing University of Chinese Medicine, No. 11, North Third Ring Road, Chaoyang District, Beijing 100029, ChinaBeijing Chinese Medicine Hospital Pinggu Hospital, No. 6, Pingxiang Road, Pinggu District, Beijing 101200, ChinaBeijing Hospital of Traditional Chinese Medicine Affiliated to Capital Medical University, No. 23 Meishuguanhou Street, Dongcheng District, Beijing 100010, ChinaBeijing Hospital of Traditional Chinese Medicine Affiliated to Capital Medical University, No. 23 Meishuguanhou Street, Dongcheng District, Beijing 100010, ChinaBeijing University of Chinese Medicine, No. 11, North Third Ring Road, Chaoyang District, Beijing 100029, ChinaBeijing Hospital of Traditional Chinese Medicine Affiliated to Capital Medical University, No. 23 Meishuguanhou Street, Dongcheng District, Beijing 100010, ChinaBeijing Hospital of Traditional Chinese Medicine Affiliated to Capital Medical University, No. 23 Meishuguanhou Street, Dongcheng District, Beijing 100010, ChinaBeijing University of Chinese Medicine, No. 11, North Third Ring Road, Chaoyang District, Beijing 100029, ChinaBeijing University of Chinese Medicine, No. 11, North Third Ring Road, Chaoyang District, Beijing 100029, ChinaBeijing University of Chinese Medicine, No. 11, North Third Ring Road, Chaoyang District, Beijing 100029, ChinaDepartment of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, USABeijing Hospital of Traditional Chinese Medicine Affiliated to Capital Medical University, No. 23 Meishuguanhou Street, Dongcheng District, Beijing 100010, ChinaRegulatory B cells (Breg) are widely regarded as immunomodulatory cells which play an immunosuppressive role. Breg inhibits pathological autoimmune response by secreting interleukin-10 (IL-10), transforming growth factor-β (TGF-β), and adenosine and through other ways to prevent T cells and other immune cells from expanding. Recent studies have shown that different inflammatory environments induce different types of Breg cells, and these different Breg cells have different functions. For example, Br1 cells can secrete IgG4 to block autoantigens. Idiopathic membranous nephropathy (IMN) is an autoimmune disease in which the humoral immune response is dominant and the cellular immune response is impaired. However, only a handful of studies have been done on the role of Bregs in this regard. In this review, we provide a brief overview of the types and functions of Breg found in human body, as well as the abnormal pathological and immunological phenomena in IMN, and propose the hypothesis that Breg is activated in IMN patients and the proportion of Br1 can be increased. Our review aims at highlighting the correlation between Breg and IMN and proposes potential mechanisms, which can provide a new direction for the discovery of the pathogenesis of IMN, thus providing a new strategy for the prevention and early treatment of IMN.http://dx.doi.org/10.1155/2020/7638365 |
| spellingShingle | Zhaocheng Dong Zhiyuan Liu Haoran Dai Wenbin Liu Zhendong Feng Qihan Zhao Yu Gao Fei Liu Na Zhang Xuan Dong Xiaoshan Zhou Jieli Du Guangrui Huang Xuefei Tian Baoli Liu The Potential Role of Regulatory B Cells in Idiopathic Membranous Nephropathy Journal of Immunology Research |
| title | The Potential Role of Regulatory B Cells in Idiopathic Membranous Nephropathy |
| title_full | The Potential Role of Regulatory B Cells in Idiopathic Membranous Nephropathy |
| title_fullStr | The Potential Role of Regulatory B Cells in Idiopathic Membranous Nephropathy |
| title_full_unstemmed | The Potential Role of Regulatory B Cells in Idiopathic Membranous Nephropathy |
| title_short | The Potential Role of Regulatory B Cells in Idiopathic Membranous Nephropathy |
| title_sort | potential role of regulatory b cells in idiopathic membranous nephropathy |
| url | http://dx.doi.org/10.1155/2020/7638365 |
| work_keys_str_mv | AT zhaochengdong thepotentialroleofregulatorybcellsinidiopathicmembranousnephropathy AT zhiyuanliu thepotentialroleofregulatorybcellsinidiopathicmembranousnephropathy AT haorandai thepotentialroleofregulatorybcellsinidiopathicmembranousnephropathy AT wenbinliu thepotentialroleofregulatorybcellsinidiopathicmembranousnephropathy AT zhendongfeng thepotentialroleofregulatorybcellsinidiopathicmembranousnephropathy AT qihanzhao thepotentialroleofregulatorybcellsinidiopathicmembranousnephropathy AT yugao thepotentialroleofregulatorybcellsinidiopathicmembranousnephropathy AT feiliu thepotentialroleofregulatorybcellsinidiopathicmembranousnephropathy AT nazhang thepotentialroleofregulatorybcellsinidiopathicmembranousnephropathy AT xuandong thepotentialroleofregulatorybcellsinidiopathicmembranousnephropathy AT xiaoshanzhou thepotentialroleofregulatorybcellsinidiopathicmembranousnephropathy AT jielidu thepotentialroleofregulatorybcellsinidiopathicmembranousnephropathy AT guangruihuang thepotentialroleofregulatorybcellsinidiopathicmembranousnephropathy AT xuefeitian thepotentialroleofregulatorybcellsinidiopathicmembranousnephropathy AT baoliliu thepotentialroleofregulatorybcellsinidiopathicmembranousnephropathy AT zhaochengdong potentialroleofregulatorybcellsinidiopathicmembranousnephropathy AT zhiyuanliu potentialroleofregulatorybcellsinidiopathicmembranousnephropathy AT haorandai potentialroleofregulatorybcellsinidiopathicmembranousnephropathy AT wenbinliu potentialroleofregulatorybcellsinidiopathicmembranousnephropathy AT zhendongfeng potentialroleofregulatorybcellsinidiopathicmembranousnephropathy AT qihanzhao potentialroleofregulatorybcellsinidiopathicmembranousnephropathy AT yugao potentialroleofregulatorybcellsinidiopathicmembranousnephropathy AT feiliu potentialroleofregulatorybcellsinidiopathicmembranousnephropathy AT nazhang potentialroleofregulatorybcellsinidiopathicmembranousnephropathy AT xuandong potentialroleofregulatorybcellsinidiopathicmembranousnephropathy AT xiaoshanzhou potentialroleofregulatorybcellsinidiopathicmembranousnephropathy AT jielidu potentialroleofregulatorybcellsinidiopathicmembranousnephropathy AT guangruihuang potentialroleofregulatorybcellsinidiopathicmembranousnephropathy AT xuefeitian potentialroleofregulatorybcellsinidiopathicmembranousnephropathy AT baoliliu potentialroleofregulatorybcellsinidiopathicmembranousnephropathy |