Insula Volume and Salience Network Are Associated with Memory Decline in Parkinson Disease: Complementary Analyses of Voxel-Based Morphometry versus Volume of Interest
Objective. We investigated structural brain change in subjects with a clinical diagnosis of Parkinson disease with mild cognitive impairment (PD-MCI) and examined its relationship with memory impairment. Methods. Twenty-three PD-MCI patients were enrolled and underwent cognitive evaluation and 3-dim...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Parkinson's Disease |
| Online Access: | http://dx.doi.org/10.1155/2016/2939528 |
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| author | Yan-Ting Lu Wen-Neng Chang Chiung-Chih Chang Cheng-Hsien Lu Nai-Ching Chen Chi-Wei Huang Wei-Che Lin Ya-Ting Chang |
| author_facet | Yan-Ting Lu Wen-Neng Chang Chiung-Chih Chang Cheng-Hsien Lu Nai-Ching Chen Chi-Wei Huang Wei-Che Lin Ya-Ting Chang |
| author_sort | Yan-Ting Lu |
| collection | DOAJ |
| description | Objective. We investigated structural brain change in subjects with a clinical diagnosis of Parkinson disease with mild cognitive impairment (PD-MCI) and examined its relationship with memory impairment. Methods. Twenty-three PD-MCI patients were enrolled and underwent cognitive evaluation and 3-dimensional T1-weighted imaging. Voxel-based morphometry (VBM) was used to assess brain-behavior correlations and examine the relationship between insula and memory score. VOI methods replicated results obtained from VBM. Results. VBM uncovered the notion that memory scores were positively correlated with the gray matter (GM) density in the insular cortex and a significant positive correlation between overall cognitive performance and concentration of GM within the lateral temporal cortex. In VOI analyses, our results suggested a positive correlation between the insula and composite free-recall verbal memory (ρ=0.617, P=0.003) and the delayed free-recall verbal memory subdomain (ρ=0.725, P<0.001). Furthermore, we found a positive correlation between the insula and caudate (σ=0.570, P=0.006) and putamen volume (σ=0.683, P<0.001). Conclusions. In patients with PD-MCI, atrophic changes in the insula may be related to memory deficits, and the brain-behavior correlation may be associated with atrophic change in the striatum within the salience network. |
| format | Article |
| id | doaj-art-fd91938c8ded47c28c90ea0038530807 |
| institution | Kabale University |
| issn | 2090-8083 2042-0080 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Parkinson's Disease |
| spelling | doaj-art-fd91938c8ded47c28c90ea00385308072025-02-03T01:27:45ZengWileyParkinson's Disease2090-80832042-00802016-01-01201610.1155/2016/29395282939528Insula Volume and Salience Network Are Associated with Memory Decline in Parkinson Disease: Complementary Analyses of Voxel-Based Morphometry versus Volume of InterestYan-Ting Lu0Wen-Neng Chang1Chiung-Chih Chang2Cheng-Hsien Lu3Nai-Ching Chen4Chi-Wei Huang5Wei-Che Lin6Ya-Ting Chang7Department of Neurology, Chang Gung University College of Medicine, Kaohsiung 83301, TaiwanDepartment of Neurology, Chang Gung University College of Medicine, Kaohsiung 83301, TaiwanDepartment of Neurology, Chang Gung University College of Medicine, Kaohsiung 83301, TaiwanDepartment of Neurology, Chang Gung University College of Medicine, Kaohsiung 83301, TaiwanDepartment of Neurology, Chang Gung University College of Medicine, Kaohsiung 83301, TaiwanDepartment of Neurology, Chang Gung University College of Medicine, Kaohsiung 83301, TaiwanDepartment of Radiology, Chang Gung University College of Medicine, Kaohsiung 83301, TaiwanDepartment of Neurology, Chang Gung University College of Medicine, Kaohsiung 83301, TaiwanObjective. We investigated structural brain change in subjects with a clinical diagnosis of Parkinson disease with mild cognitive impairment (PD-MCI) and examined its relationship with memory impairment. Methods. Twenty-three PD-MCI patients were enrolled and underwent cognitive evaluation and 3-dimensional T1-weighted imaging. Voxel-based morphometry (VBM) was used to assess brain-behavior correlations and examine the relationship between insula and memory score. VOI methods replicated results obtained from VBM. Results. VBM uncovered the notion that memory scores were positively correlated with the gray matter (GM) density in the insular cortex and a significant positive correlation between overall cognitive performance and concentration of GM within the lateral temporal cortex. In VOI analyses, our results suggested a positive correlation between the insula and composite free-recall verbal memory (ρ=0.617, P=0.003) and the delayed free-recall verbal memory subdomain (ρ=0.725, P<0.001). Furthermore, we found a positive correlation between the insula and caudate (σ=0.570, P=0.006) and putamen volume (σ=0.683, P<0.001). Conclusions. In patients with PD-MCI, atrophic changes in the insula may be related to memory deficits, and the brain-behavior correlation may be associated with atrophic change in the striatum within the salience network.http://dx.doi.org/10.1155/2016/2939528 |
| spellingShingle | Yan-Ting Lu Wen-Neng Chang Chiung-Chih Chang Cheng-Hsien Lu Nai-Ching Chen Chi-Wei Huang Wei-Che Lin Ya-Ting Chang Insula Volume and Salience Network Are Associated with Memory Decline in Parkinson Disease: Complementary Analyses of Voxel-Based Morphometry versus Volume of Interest Parkinson's Disease |
| title | Insula Volume and Salience Network Are Associated with Memory Decline in Parkinson Disease: Complementary Analyses of Voxel-Based Morphometry versus Volume of Interest |
| title_full | Insula Volume and Salience Network Are Associated with Memory Decline in Parkinson Disease: Complementary Analyses of Voxel-Based Morphometry versus Volume of Interest |
| title_fullStr | Insula Volume and Salience Network Are Associated with Memory Decline in Parkinson Disease: Complementary Analyses of Voxel-Based Morphometry versus Volume of Interest |
| title_full_unstemmed | Insula Volume and Salience Network Are Associated with Memory Decline in Parkinson Disease: Complementary Analyses of Voxel-Based Morphometry versus Volume of Interest |
| title_short | Insula Volume and Salience Network Are Associated with Memory Decline in Parkinson Disease: Complementary Analyses of Voxel-Based Morphometry versus Volume of Interest |
| title_sort | insula volume and salience network are associated with memory decline in parkinson disease complementary analyses of voxel based morphometry versus volume of interest |
| url | http://dx.doi.org/10.1155/2016/2939528 |
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