Saturated Fatty Acid-Induced Cytotoxicity in Liver Cells Does Not Involve Phosphatase and Tensin Homologue Deleted on Chromosome 10

Saturated Fatty Acid-Induced Cytotoxicity in Liver Cells Does Not Involve Phosphatase and Tensin Homologue Deleted on Chromosome 10

Liver specific deletion of the tumor suppressor phosphatase and tensin homologue deleted on chromosome 10 (PTEN) induces steatosis and hypersensitivity to insulin. Saturated fatty acids, which induce endoplasmic reticulum stress and cell death, appear to increase PTEN, whereas unsaturated fatty acid...

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Bibliographic Details
Main Authors:	Dong Wang, Yuren Wei, Melinda Frye, Christopher L. Gentile, Michael J. Pagliassotti
Format:	Article
Language:	English
Published:	Wiley 2013-01-01
Series:	Journal of Nutrition and Metabolism
Online Access:	http://dx.doi.org/10.1155/2013/514206
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