Modulation of Sleep Homeostasis by Corticotropin Releasing Hormone in REM Sleep-Deprived Rats
Studies have shown that sleep recovery following different protocols of forced waking varies according to the level of stress inherent to each method. Sleep deprivation activates the hypothalamic-pituitary-adrenal axis and increased corticotropin-releasing hormone (CRH) impairs sleep. The purpose of...
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| Format: | Article |
| Language: | English |
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Wiley
2010-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2010/326151 |
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| author | Ricardo Borges Machado Sergio Tufik Deborah Suchecki |
| author_facet | Ricardo Borges Machado Sergio Tufik Deborah Suchecki |
| author_sort | Ricardo Borges Machado |
| collection | DOAJ |
| description | Studies have shown that sleep recovery following different protocols of forced waking varies according to the level of stress inherent to each method. Sleep deprivation activates the hypothalamic-pituitary-adrenal axis and increased corticotropin-releasing hormone (CRH) impairs sleep. The purpose of the present study was to evaluate how manipulations of the CRH system during the sleep deprivation period interferes with subsequent sleep rebound. Throughout 96 hours of sleep deprivation, separate groups of rats were treated i.c.v. with vehicle, CRH or with alphahelical CRH9−41, a CRH receptor blocker, twice/day, at 07:00 h and 19:00 h. Both treatments impaired sleep homeostasis, especially in regards to length of rapid eye movement sleep (REM) and theta/delta ratio and induced a later decrease in NREM and REM sleep and increased waking bouts. These changes suggest that activation of the CRH system impact negatively on the homeostatic sleep response to prolonged forced waking. These results indicate that indeed, activation of the HPA axis—at least at the hypothalamic level—is capable to reduce the sleep rebound induced by sleep deprivation. |
| format | Article |
| id | doaj-art-fd6883e257044bc9b128ecaff9914220 |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-fd6883e257044bc9b128ecaff99142202025-02-03T01:10:20ZengWileyInternational Journal of Endocrinology1687-83371687-83452010-01-01201010.1155/2010/326151326151Modulation of Sleep Homeostasis by Corticotropin Releasing Hormone in REM Sleep-Deprived RatsRicardo Borges Machado0Sergio Tufik1Deborah Suchecki2Departamento de Psicobiologia, Universidade Federal de São Paulo, 04024-002 São Paulo, BrazilDepartamento de Psicobiologia, Universidade Federal de São Paulo, 04024-002 São Paulo, BrazilDepartamento de Psicobiologia, Universidade Federal de São Paulo, 04024-002 São Paulo, BrazilStudies have shown that sleep recovery following different protocols of forced waking varies according to the level of stress inherent to each method. Sleep deprivation activates the hypothalamic-pituitary-adrenal axis and increased corticotropin-releasing hormone (CRH) impairs sleep. The purpose of the present study was to evaluate how manipulations of the CRH system during the sleep deprivation period interferes with subsequent sleep rebound. Throughout 96 hours of sleep deprivation, separate groups of rats were treated i.c.v. with vehicle, CRH or with alphahelical CRH9−41, a CRH receptor blocker, twice/day, at 07:00 h and 19:00 h. Both treatments impaired sleep homeostasis, especially in regards to length of rapid eye movement sleep (REM) and theta/delta ratio and induced a later decrease in NREM and REM sleep and increased waking bouts. These changes suggest that activation of the CRH system impact negatively on the homeostatic sleep response to prolonged forced waking. These results indicate that indeed, activation of the HPA axis—at least at the hypothalamic level—is capable to reduce the sleep rebound induced by sleep deprivation.http://dx.doi.org/10.1155/2010/326151 |
| spellingShingle | Ricardo Borges Machado Sergio Tufik Deborah Suchecki Modulation of Sleep Homeostasis by Corticotropin Releasing Hormone in REM Sleep-Deprived Rats International Journal of Endocrinology |
| title | Modulation of Sleep Homeostasis by Corticotropin Releasing Hormone in REM Sleep-Deprived Rats |
| title_full | Modulation of Sleep Homeostasis by Corticotropin Releasing Hormone in REM Sleep-Deprived Rats |
| title_fullStr | Modulation of Sleep Homeostasis by Corticotropin Releasing Hormone in REM Sleep-Deprived Rats |
| title_full_unstemmed | Modulation of Sleep Homeostasis by Corticotropin Releasing Hormone in REM Sleep-Deprived Rats |
| title_short | Modulation of Sleep Homeostasis by Corticotropin Releasing Hormone in REM Sleep-Deprived Rats |
| title_sort | modulation of sleep homeostasis by corticotropin releasing hormone in rem sleep deprived rats |
| url | http://dx.doi.org/10.1155/2010/326151 |
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