Peripheral T-Cell Lymphoma with Aberrant Expression of CD19, CD20, and CD79a: Case Report and Literature Review
A case of lymphoma of T-cell derivation with aberrant expression of three B-cell lineage markers (CD19, CD20, and CD79a), which was diagnosed on a left axillary excision, is described. Immunohistochemical studies and flow cytometry analysis demonstrated neoplastic cells expressing CD3, CD19, CD20,...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2013-01-01
|
| Series: | Case Reports in Hematology |
| Online Access: | http://dx.doi.org/10.1155/2013/183134 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832552542207213568 |
|---|---|
| author | Rahul G. Matnani Rachel L. Stewart Joseph Pulliam Chester D. Jennings Melissa Kesler |
| author_facet | Rahul G. Matnani Rachel L. Stewart Joseph Pulliam Chester D. Jennings Melissa Kesler |
| author_sort | Rahul G. Matnani |
| collection | DOAJ |
| description | A case of lymphoma of T-cell derivation with aberrant expression of three B-cell lineage markers (CD19, CD20, and CD79a), which was diagnosed on a left axillary excision, is described. Immunohistochemical studies and flow cytometry analysis demonstrated neoplastic cells expressing CD3, CD19, CD20, and CD79a with absence of CD4, CD8, CD10, CD30, CD34, CD56, CD68, TDT, MPO, PAX-5, and surface immunoglobulin. Gene rearrangement studies performed on paraffin blocks demonstrated monoclonal T-cell receptor gamma chain rearrangement with no evidence of clonal heavy chain rearrangement. The neoplastic cells were negative for Epstein-Barr virus (EBV) or Human Herpes Virus 8 (HHV-8). At the time of diagnosis, the PET scan demonstrated hypermetabolic neoplastic cells involving the left axilla, bilateral internal jugular areas, mediastinum, right hilum, bilateral lungs, and spleen. However, bone marrow biopsy performed for hemolytic anemia revealed normocellular bone marrow with trilineage maturation. The patient had no evidence of immunodeficiency or infection with EBV or HHV-8. This is the first reported case of a mature T-cell lymphoma with aberrant expression of three B-cell lineage markers. The current report also highlights the need for molecular gene rearrangement studies to determine the precise lineage of ambiguous neoplastic clones. |
| format | Article |
| id | doaj-art-fd65e34d637f4811a6d2bfdc38819a52 |
| institution | Kabale University |
| issn | 2090-6560 2090-6579 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Hematology |
| spelling | doaj-art-fd65e34d637f4811a6d2bfdc38819a522025-02-03T05:58:33ZengWileyCase Reports in Hematology2090-65602090-65792013-01-01201310.1155/2013/183134183134Peripheral T-Cell Lymphoma with Aberrant Expression of CD19, CD20, and CD79a: Case Report and Literature ReviewRahul G. Matnani0Rachel L. Stewart1Joseph Pulliam2Chester D. Jennings3Melissa Kesler4Department of Pathology & Laboratory Medicine, Chandler Medical Center, College of Medicine, University of Kentucky, 800 Rose Street, Lexington, KY 40536-0298, USADepartment of Pathology & Laboratory Medicine, Chandler Medical Center, College of Medicine, University of Kentucky, 800 Rose Street, Lexington, KY 40536-0298, USADepartment of Pathology & Laboratory Medicine, Chandler Medical Center, College of Medicine, University of Kentucky, 800 Rose Street, Lexington, KY 40536-0298, USADepartment of Pathology & Laboratory Medicine, Chandler Medical Center, College of Medicine, University of Kentucky, 800 Rose Street, Lexington, KY 40536-0298, USADepartment of Pathology & Laboratory Medicine, Chandler Medical Center, College of Medicine, University of Kentucky, 800 Rose Street, Lexington, KY 40536-0298, USAA case of lymphoma of T-cell derivation with aberrant expression of three B-cell lineage markers (CD19, CD20, and CD79a), which was diagnosed on a left axillary excision, is described. Immunohistochemical studies and flow cytometry analysis demonstrated neoplastic cells expressing CD3, CD19, CD20, and CD79a with absence of CD4, CD8, CD10, CD30, CD34, CD56, CD68, TDT, MPO, PAX-5, and surface immunoglobulin. Gene rearrangement studies performed on paraffin blocks demonstrated monoclonal T-cell receptor gamma chain rearrangement with no evidence of clonal heavy chain rearrangement. The neoplastic cells were negative for Epstein-Barr virus (EBV) or Human Herpes Virus 8 (HHV-8). At the time of diagnosis, the PET scan demonstrated hypermetabolic neoplastic cells involving the left axilla, bilateral internal jugular areas, mediastinum, right hilum, bilateral lungs, and spleen. However, bone marrow biopsy performed for hemolytic anemia revealed normocellular bone marrow with trilineage maturation. The patient had no evidence of immunodeficiency or infection with EBV or HHV-8. This is the first reported case of a mature T-cell lymphoma with aberrant expression of three B-cell lineage markers. The current report also highlights the need for molecular gene rearrangement studies to determine the precise lineage of ambiguous neoplastic clones.http://dx.doi.org/10.1155/2013/183134 |
| spellingShingle | Rahul G. Matnani Rachel L. Stewart Joseph Pulliam Chester D. Jennings Melissa Kesler Peripheral T-Cell Lymphoma with Aberrant Expression of CD19, CD20, and CD79a: Case Report and Literature Review Case Reports in Hematology |
| title | Peripheral T-Cell Lymphoma with Aberrant Expression of CD19, CD20, and CD79a: Case Report and Literature Review |
| title_full | Peripheral T-Cell Lymphoma with Aberrant Expression of CD19, CD20, and CD79a: Case Report and Literature Review |
| title_fullStr | Peripheral T-Cell Lymphoma with Aberrant Expression of CD19, CD20, and CD79a: Case Report and Literature Review |
| title_full_unstemmed | Peripheral T-Cell Lymphoma with Aberrant Expression of CD19, CD20, and CD79a: Case Report and Literature Review |
| title_short | Peripheral T-Cell Lymphoma with Aberrant Expression of CD19, CD20, and CD79a: Case Report and Literature Review |
| title_sort | peripheral t cell lymphoma with aberrant expression of cd19 cd20 and cd79a case report and literature review |
| url | http://dx.doi.org/10.1155/2013/183134 |
| work_keys_str_mv | AT rahulgmatnani peripheraltcelllymphomawithaberrantexpressionofcd19cd20andcd79acasereportandliteraturereview AT rachellstewart peripheraltcelllymphomawithaberrantexpressionofcd19cd20andcd79acasereportandliteraturereview AT josephpulliam peripheraltcelllymphomawithaberrantexpressionofcd19cd20andcd79acasereportandliteraturereview AT chesterdjennings peripheraltcelllymphomawithaberrantexpressionofcd19cd20andcd79acasereportandliteraturereview AT melissakesler peripheraltcelllymphomawithaberrantexpressionofcd19cd20andcd79acasereportandliteraturereview |