Essential Thrombocythemia Complicated by Occlusive Thrombosis of the Abdominal Aorta
Introduction. Essential thrombocythemia (ET) is a myeloproliferative neoplasm of excessive platelet production complicated by thrombohemorrhagic events. Thrombosis typically occurs in small to medium vessels; thrombosis of large vessels is rare. Case Presentation. A 75-year-old woman with ET complic...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2019-01-01
|
| Series: | Case Reports in Hematology |
| Online Access: | http://dx.doi.org/10.1155/2019/9454501 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832562578005426176 |
|---|---|
| author | Jamie Geringer Joshua Fenderson Michael Osswald |
| author_facet | Jamie Geringer Joshua Fenderson Michael Osswald |
| author_sort | Jamie Geringer |
| collection | DOAJ |
| description | Introduction. Essential thrombocythemia (ET) is a myeloproliferative neoplasm of excessive platelet production complicated by thrombohemorrhagic events. Thrombosis typically occurs in small to medium vessels; thrombosis of large vessels is rare. Case Presentation. A 75-year-old woman with ET complicated by bilateral retinal vein occlusion was evaluated for fatigue, early satiety, and unintentional weight loss. Her hypertension was well controlled, and her chronic lower extremity claudication from peripheral artery disease was stable. She reported adherence to aspirin 81 mg and hydroxyurea 1000 mg daily, and her platelets (375 × 109/L) were at goal. Bone marrow biopsy was consistent with ET without progression to myelofibrosis or leukemia. CT abdomen demonstrated complete occlusion of the infrarenal aorta, extending into the common iliac arteries, with reconstitution of flow distally via collaterals. The addition of clopidogrel, for platelet inhibition, and cilostazol, for claudication, caused symptom improvement without further thrombosis or bleeding. Discussion. There are few published reports of ET complicated by aortic thrombosis. To our knowledge, this is the first report of aortic thrombosis occurring in an ET patient with normal platelet count on antiplatelet and cytoreductive therapies. There is limited evidence to guide treatment, but medical management with triple antiplatelet therapy may be effective in selected patients. |
| format | Article |
| id | doaj-art-fd62ebe87ecd41b2b1c02253a51eaaa3 |
| institution | Kabale University |
| issn | 2090-6560 2090-6579 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Hematology |
| spelling | doaj-art-fd62ebe87ecd41b2b1c02253a51eaaa32025-02-03T01:22:22ZengWileyCase Reports in Hematology2090-65602090-65792019-01-01201910.1155/2019/94545019454501Essential Thrombocythemia Complicated by Occlusive Thrombosis of the Abdominal AortaJamie Geringer0Joshua Fenderson1Michael Osswald2San Antonio Uniformed Services Health Education Consortium, 3551 Roger Brooke Drive JBSA, Fort Sam Houston, San Antonio, TX 78234, USASan Antonio Uniformed Services Health Education Consortium, 3551 Roger Brooke Drive JBSA, Fort Sam Houston, San Antonio, TX 78234, USASan Antonio Uniformed Services Health Education Consortium, 3551 Roger Brooke Drive JBSA, Fort Sam Houston, San Antonio, TX 78234, USAIntroduction. Essential thrombocythemia (ET) is a myeloproliferative neoplasm of excessive platelet production complicated by thrombohemorrhagic events. Thrombosis typically occurs in small to medium vessels; thrombosis of large vessels is rare. Case Presentation. A 75-year-old woman with ET complicated by bilateral retinal vein occlusion was evaluated for fatigue, early satiety, and unintentional weight loss. Her hypertension was well controlled, and her chronic lower extremity claudication from peripheral artery disease was stable. She reported adherence to aspirin 81 mg and hydroxyurea 1000 mg daily, and her platelets (375 × 109/L) were at goal. Bone marrow biopsy was consistent with ET without progression to myelofibrosis or leukemia. CT abdomen demonstrated complete occlusion of the infrarenal aorta, extending into the common iliac arteries, with reconstitution of flow distally via collaterals. The addition of clopidogrel, for platelet inhibition, and cilostazol, for claudication, caused symptom improvement without further thrombosis or bleeding. Discussion. There are few published reports of ET complicated by aortic thrombosis. To our knowledge, this is the first report of aortic thrombosis occurring in an ET patient with normal platelet count on antiplatelet and cytoreductive therapies. There is limited evidence to guide treatment, but medical management with triple antiplatelet therapy may be effective in selected patients.http://dx.doi.org/10.1155/2019/9454501 |
| spellingShingle | Jamie Geringer Joshua Fenderson Michael Osswald Essential Thrombocythemia Complicated by Occlusive Thrombosis of the Abdominal Aorta Case Reports in Hematology |
| title | Essential Thrombocythemia Complicated by Occlusive Thrombosis of the Abdominal Aorta |
| title_full | Essential Thrombocythemia Complicated by Occlusive Thrombosis of the Abdominal Aorta |
| title_fullStr | Essential Thrombocythemia Complicated by Occlusive Thrombosis of the Abdominal Aorta |
| title_full_unstemmed | Essential Thrombocythemia Complicated by Occlusive Thrombosis of the Abdominal Aorta |
| title_short | Essential Thrombocythemia Complicated by Occlusive Thrombosis of the Abdominal Aorta |
| title_sort | essential thrombocythemia complicated by occlusive thrombosis of the abdominal aorta |
| url | http://dx.doi.org/10.1155/2019/9454501 |
| work_keys_str_mv | AT jamiegeringer essentialthrombocythemiacomplicatedbyocclusivethrombosisoftheabdominalaorta AT joshuafenderson essentialthrombocythemiacomplicatedbyocclusivethrombosisoftheabdominalaorta AT michaelosswald essentialthrombocythemiacomplicatedbyocclusivethrombosisoftheabdominalaorta |