Anticancer activity of mixed Graphene/Carbone nanotubes reinforced Sulfur-Containing polyketoamine nanocomposites
This study reports the successful synthesis of a novel polyketoamine (PKA) and its nanocomposites, including graphene nanosheets (GNS) and multi-wall carbon nanotubes (MWCNT), through an in-situ polycondensation reaction incorporating sulfur and thiazole moieties. A hybrid nanofiller composed of MWC...
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Elsevier
2025-01-01
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| Series: | Results in Chemistry |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211715624006982 |
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| author | Khalid A. Khan Gadeer R. Ashour Mahmoud A. Hussein |
| author_facet | Khalid A. Khan Gadeer R. Ashour Mahmoud A. Hussein |
| author_sort | Khalid A. Khan |
| collection | DOAJ |
| description | This study reports the successful synthesis of a novel polyketoamine (PKA) and its nanocomposites, including graphene nanosheets (GNS) and multi-wall carbon nanotubes (MWCNT), through an in-situ polycondensation reaction incorporating sulfur and thiazole moieties. A hybrid nanofiller composed of MWCNT and GNS (MWCNT-GNS) was prepared using a straightforward method, serving as a mixed reinforcement in the nanocomposite polymers. The polymerization process utilized 4,4′-bis-chloroacetyl-diphenylsulfide and 4,4′-bis-(2-aminothiazole-4′’-yl)diphenylsulfide in absolute ethanol. The structure and properties of the synthesized materials were comprehensively analyzed through various techniques, including Fourier Transform Infrared Spectroscopy (FTIR), Thermogravimetric Analysis (TGA), X-ray Diffraction (XRD), Gel Permeation Chromatography (GPC), and solubility testing. Morphological characteristics were examined using Field Emission Scanning Electron Microscopy (FESEM) and Transmission Electron Microscopy (TEM). This multi-faceted analytical approach provided a thorough understanding of both structural and morphological attributes. The synthesized PKA nanocomposites demonstrated significant antimicrobial and anticancer activities, showcasing their versatile properties and potential applications. Among the materials, PKA/GNS/MWCNTsd exhibited the highest antifungal efficacy, particularly against Candida albicans and Aspergillus flavus, with antifungal activity (inhibition zones measuring 14 and 13 mm) increasing with higher GNS/MWCNT content. The nanocomposites also showed pronounced anticancer effects, with PKA/GNS/MWCNTsa (IC50 = 92.89 μg/mL) being the most effective, followed by PKA/GNS/MWCNTsd (IC50 = 104.0 μg/mL), PKA/GNS/MWCNTsc (IC50 = 109.5 μg/mL), PKA/GNS/MWCNTsb (IC50 = 110.1 μg/mL), and pure PKA (IC50 = 149.4 μg/mL). Methylene blue staining confirmed the suppression of cancer cell growth, particularly with PKA/GNS/MWCNTsd, highlighting their potential for clinical applications. |
| format | Article |
| id | doaj-art-fd5a01ce22c041c9b79c8d240d01da03 |
| institution | Kabale University |
| issn | 2211-7156 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Results in Chemistry |
| spelling | doaj-art-fd5a01ce22c041c9b79c8d240d01da032025-01-29T05:00:52ZengElsevierResults in Chemistry2211-71562025-01-0113102002Anticancer activity of mixed Graphene/Carbone nanotubes reinforced Sulfur-Containing polyketoamine nanocompositesKhalid A. Khan0Gadeer R. Ashour1Mahmoud A. Hussein2Chemistry Department, Faculty of Science, King Abdulaziz University, P.O. Box 80203, Jeddah 21589, Saudi ArabiaDepartment of Chemistry, Faculty of Applied Sciences, Umm Al Qura University, Makkah, Saudi ArabiaDepartment of Chemistry, Faculty of Applied Sciences, Umm Al Qura University, Makkah, Saudi Arabia; Chemistry Department, Faculty of Science, Assiut University, Assiut 71516, Egypt; Corresponding author at: Chemistry Department, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia.This study reports the successful synthesis of a novel polyketoamine (PKA) and its nanocomposites, including graphene nanosheets (GNS) and multi-wall carbon nanotubes (MWCNT), through an in-situ polycondensation reaction incorporating sulfur and thiazole moieties. A hybrid nanofiller composed of MWCNT and GNS (MWCNT-GNS) was prepared using a straightforward method, serving as a mixed reinforcement in the nanocomposite polymers. The polymerization process utilized 4,4′-bis-chloroacetyl-diphenylsulfide and 4,4′-bis-(2-aminothiazole-4′’-yl)diphenylsulfide in absolute ethanol. The structure and properties of the synthesized materials were comprehensively analyzed through various techniques, including Fourier Transform Infrared Spectroscopy (FTIR), Thermogravimetric Analysis (TGA), X-ray Diffraction (XRD), Gel Permeation Chromatography (GPC), and solubility testing. Morphological characteristics were examined using Field Emission Scanning Electron Microscopy (FESEM) and Transmission Electron Microscopy (TEM). This multi-faceted analytical approach provided a thorough understanding of both structural and morphological attributes. The synthesized PKA nanocomposites demonstrated significant antimicrobial and anticancer activities, showcasing their versatile properties and potential applications. Among the materials, PKA/GNS/MWCNTsd exhibited the highest antifungal efficacy, particularly against Candida albicans and Aspergillus flavus, with antifungal activity (inhibition zones measuring 14 and 13 mm) increasing with higher GNS/MWCNT content. The nanocomposites also showed pronounced anticancer effects, with PKA/GNS/MWCNTsa (IC50 = 92.89 μg/mL) being the most effective, followed by PKA/GNS/MWCNTsd (IC50 = 104.0 μg/mL), PKA/GNS/MWCNTsc (IC50 = 109.5 μg/mL), PKA/GNS/MWCNTsb (IC50 = 110.1 μg/mL), and pure PKA (IC50 = 149.4 μg/mL). Methylene blue staining confirmed the suppression of cancer cell growth, particularly with PKA/GNS/MWCNTsd, highlighting their potential for clinical applications.http://www.sciencedirect.com/science/article/pii/S2211715624006982Sulfur containing polyketoaminesNanocomposite materialsAnticancer activityThermal propertiesGNSs/MWCNTs mixed filler |
| spellingShingle | Khalid A. Khan Gadeer R. Ashour Mahmoud A. Hussein Anticancer activity of mixed Graphene/Carbone nanotubes reinforced Sulfur-Containing polyketoamine nanocomposites Results in Chemistry Sulfur containing polyketoamines Nanocomposite materials Anticancer activity Thermal properties GNSs/MWCNTs mixed filler |
| title | Anticancer activity of mixed Graphene/Carbone nanotubes reinforced Sulfur-Containing polyketoamine nanocomposites |
| title_full | Anticancer activity of mixed Graphene/Carbone nanotubes reinforced Sulfur-Containing polyketoamine nanocomposites |
| title_fullStr | Anticancer activity of mixed Graphene/Carbone nanotubes reinforced Sulfur-Containing polyketoamine nanocomposites |
| title_full_unstemmed | Anticancer activity of mixed Graphene/Carbone nanotubes reinforced Sulfur-Containing polyketoamine nanocomposites |
| title_short | Anticancer activity of mixed Graphene/Carbone nanotubes reinforced Sulfur-Containing polyketoamine nanocomposites |
| title_sort | anticancer activity of mixed graphene carbone nanotubes reinforced sulfur containing polyketoamine nanocomposites |
| topic | Sulfur containing polyketoamines Nanocomposite materials Anticancer activity Thermal properties GNSs/MWCNTs mixed filler |
| url | http://www.sciencedirect.com/science/article/pii/S2211715624006982 |
| work_keys_str_mv | AT khalidakhan anticanceractivityofmixedgraphenecarbonenanotubesreinforcedsulfurcontainingpolyketoaminenanocomposites AT gadeerrashour anticanceractivityofmixedgraphenecarbonenanotubesreinforcedsulfurcontainingpolyketoaminenanocomposites AT mahmoudahussein anticanceractivityofmixedgraphenecarbonenanotubesreinforcedsulfurcontainingpolyketoaminenanocomposites |