Heart-on-a-chip: a revolutionary organ-on-chip platform for cardiovascular disease modeling
Abstract Heart-on-a-chip (HoC) devices have emerged as a powerful tool for studying the human heart's intricate functions and dysfunctions in vitro. Traditional preclinical models, such as 2D cell cultures model and animal model, have limitations in accurately predicting human response to cardi...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2025-01-01
|
| Series: | Journal of Translational Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12967-024-05986-y |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832571418218332160 |
|---|---|
| author | Beiqin Liu Shuyue Wang Hong Ma Yulin Deng Jichen Du Yimeng Zhao Yu Chen |
| author_facet | Beiqin Liu Shuyue Wang Hong Ma Yulin Deng Jichen Du Yimeng Zhao Yu Chen |
| author_sort | Beiqin Liu |
| collection | DOAJ |
| description | Abstract Heart-on-a-chip (HoC) devices have emerged as a powerful tool for studying the human heart's intricate functions and dysfunctions in vitro. Traditional preclinical models, such as 2D cell cultures model and animal model, have limitations in accurately predicting human response to cardiovascular diseases and treatments. The HoC approach addresses these shortcomings by recapitulating the microscale anatomy, physiology, and biomechanics of the heart, thereby providing a more clinically relevant platform for drug testing, disease modeling, and personalized therapy. Recent years have seen significant strides in HoC technology, driven by advancements in biomaterials, bioelectronics, and tissue engineering. Here, we first review the construction and on-chip detection in HoC. Then we introduce the current proceedings of in vitro models for studying cardiovascular diseases (CVD) based on the HoC platform, including ischemia and myocardial infarction, cardiac fibrosis, cardiac scar, myocardial hypertrophy and other CVD models. Finally, we discuss the future directions of HoC and related emerging technologies. Graphical Abstract |
| format | Article |
| id | doaj-art-fd54a49064194d949aec4723fd3f77e5 |
| institution | Kabale University |
| issn | 1479-5876 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Translational Medicine |
| spelling | doaj-art-fd54a49064194d949aec4723fd3f77e52025-02-02T12:40:23ZengBMCJournal of Translational Medicine1479-58762025-01-0123112410.1186/s12967-024-05986-yHeart-on-a-chip: a revolutionary organ-on-chip platform for cardiovascular disease modelingBeiqin Liu0Shuyue Wang1Hong Ma2Yulin Deng3Jichen Du4Yimeng Zhao5Yu Chen6Aerospace Medical Center, Aerospace Center HospitalSchool of Medical Technology, Beijing Institute of TechnologySchool of Medical Technology, Beijing Institute of TechnologySchool of Medical Technology, Beijing Institute of TechnologyAerospace Medical Center, Aerospace Center HospitalSchool of Medical Technology, Beijing Institute of TechnologyAerospace Medical Center, Aerospace Center HospitalAbstract Heart-on-a-chip (HoC) devices have emerged as a powerful tool for studying the human heart's intricate functions and dysfunctions in vitro. Traditional preclinical models, such as 2D cell cultures model and animal model, have limitations in accurately predicting human response to cardiovascular diseases and treatments. The HoC approach addresses these shortcomings by recapitulating the microscale anatomy, physiology, and biomechanics of the heart, thereby providing a more clinically relevant platform for drug testing, disease modeling, and personalized therapy. Recent years have seen significant strides in HoC technology, driven by advancements in biomaterials, bioelectronics, and tissue engineering. Here, we first review the construction and on-chip detection in HoC. Then we introduce the current proceedings of in vitro models for studying cardiovascular diseases (CVD) based on the HoC platform, including ischemia and myocardial infarction, cardiac fibrosis, cardiac scar, myocardial hypertrophy and other CVD models. Finally, we discuss the future directions of HoC and related emerging technologies. Graphical Abstracthttps://doi.org/10.1186/s12967-024-05986-yHeart-on-a-chipIn vitro modelingOn-chip detectionCardiovascular diseasesDrug testing |
| spellingShingle | Beiqin Liu Shuyue Wang Hong Ma Yulin Deng Jichen Du Yimeng Zhao Yu Chen Heart-on-a-chip: a revolutionary organ-on-chip platform for cardiovascular disease modeling Journal of Translational Medicine Heart-on-a-chip In vitro modeling On-chip detection Cardiovascular diseases Drug testing |
| title | Heart-on-a-chip: a revolutionary organ-on-chip platform for cardiovascular disease modeling |
| title_full | Heart-on-a-chip: a revolutionary organ-on-chip platform for cardiovascular disease modeling |
| title_fullStr | Heart-on-a-chip: a revolutionary organ-on-chip platform for cardiovascular disease modeling |
| title_full_unstemmed | Heart-on-a-chip: a revolutionary organ-on-chip platform for cardiovascular disease modeling |
| title_short | Heart-on-a-chip: a revolutionary organ-on-chip platform for cardiovascular disease modeling |
| title_sort | heart on a chip a revolutionary organ on chip platform for cardiovascular disease modeling |
| topic | Heart-on-a-chip In vitro modeling On-chip detection Cardiovascular diseases Drug testing |
| url | https://doi.org/10.1186/s12967-024-05986-y |
| work_keys_str_mv | AT beiqinliu heartonachiparevolutionaryorganonchipplatformforcardiovasculardiseasemodeling AT shuyuewang heartonachiparevolutionaryorganonchipplatformforcardiovasculardiseasemodeling AT hongma heartonachiparevolutionaryorganonchipplatformforcardiovasculardiseasemodeling AT yulindeng heartonachiparevolutionaryorganonchipplatformforcardiovasculardiseasemodeling AT jichendu heartonachiparevolutionaryorganonchipplatformforcardiovasculardiseasemodeling AT yimengzhao heartonachiparevolutionaryorganonchipplatformforcardiovasculardiseasemodeling AT yuchen heartonachiparevolutionaryorganonchipplatformforcardiovasculardiseasemodeling |