Feedback regulation in multistage cell lineages
Studies of developing and self-renewing tissues have shown thatdifferentiated cell types are typically specified through the actions ofmultistage cell lineages. Such lineages commonly include a stem celland multiple progenitor (transit amplifying; TA) cell stages, which ultimatelygive rise to termin...
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| Format: | Article |
| Language: | English |
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AIMS Press
2008-11-01
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| Series: | Mathematical Biosciences and Engineering |
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| Online Access: | https://www.aimspress.com/article/doi/10.3934/mbe.2009.6.59 |
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| author | Wing-Cheong Lo Ching-Shan Chou Kimberly K. Gokoffski Frederic Y.-M. Wan Arthur D. Lander Anne L. Calof Qing Nie |
| author_facet | Wing-Cheong Lo Ching-Shan Chou Kimberly K. Gokoffski Frederic Y.-M. Wan Arthur D. Lander Anne L. Calof Qing Nie |
| author_sort | Wing-Cheong Lo |
| collection | DOAJ |
| description | Studies of developing and self-renewing tissues have shown thatdifferentiated cell types are typically specified through the actions ofmultistage cell lineages. Such lineages commonly include a stem celland multiple progenitor (transit amplifying; TA) cell stages, which ultimatelygive rise to terminally differentiated (TD) cells. In several cases, self-renewaland differentiation of stem and progenitor cells within such lineages have beenshown to be under feedback regulation. Together, the existence of multiple cellstages within a lineage and complex feedback regulation are thought to conferupon a tissue the ability to autoregulate development and regeneration,in terms of both cell number (total tissue volume) and cell identity(the proportions of different cell types, especially TD cells, within the tissue).In this paper, we model neurogenesis in the olfactory epithelium (OE) of the mouse,a system in which the lineage stages and mediators of feedback regulation that governthe generation of terminally differentiated olfactory receptor neurons (ORNs) have beenthe subject of much experimental work. Here we report on the existence and uniquenessof steady states in this system, as well as local and global stability of these steady states.In particular, we identify parameter conditions for the stability of the system when negativefeedback loops are represented either as Hill functions, or in more general terms.Our results suggest that two factors -- autoregulation of the proliferation oftransit amplifying (TA) progenitor cells, and a low death rate of TD cells -- enhance the stability of this system. |
| format | Article |
| id | doaj-art-fd4cfb4d2d684344a2926ee08785a08b |
| institution | Kabale University |
| issn | 1551-0018 |
| language | English |
| publishDate | 2008-11-01 |
| publisher | AIMS Press |
| record_format | Article |
| series | Mathematical Biosciences and Engineering |
| spelling | doaj-art-fd4cfb4d2d684344a2926ee08785a08b2025-01-24T01:58:53ZengAIMS PressMathematical Biosciences and Engineering1551-00182008-11-0161598210.3934/mbe.2009.6.59Feedback regulation in multistage cell lineagesWing-Cheong Lo0Ching-Shan Chou1Kimberly K. Gokoffski2Frederic Y.-M. Wan3Arthur D. Lander4Anne L. Calof5Qing Nie6Departments of Mathematics, University of California, Irvine, CADepartments of Mathematics, University of California, Irvine, CADepartments of Mathematics, University of California, Irvine, CADepartments of Mathematics, University of California, Irvine, CADepartments of Mathematics, University of California, Irvine, CADepartments of Mathematics, University of California, Irvine, CADepartments of Mathematics, University of California, Irvine, CAStudies of developing and self-renewing tissues have shown thatdifferentiated cell types are typically specified through the actions ofmultistage cell lineages. Such lineages commonly include a stem celland multiple progenitor (transit amplifying; TA) cell stages, which ultimatelygive rise to terminally differentiated (TD) cells. In several cases, self-renewaland differentiation of stem and progenitor cells within such lineages have beenshown to be under feedback regulation. Together, the existence of multiple cellstages within a lineage and complex feedback regulation are thought to conferupon a tissue the ability to autoregulate development and regeneration,in terms of both cell number (total tissue volume) and cell identity(the proportions of different cell types, especially TD cells, within the tissue).In this paper, we model neurogenesis in the olfactory epithelium (OE) of the mouse,a system in which the lineage stages and mediators of feedback regulation that governthe generation of terminally differentiated olfactory receptor neurons (ORNs) have beenthe subject of much experimental work. Here we report on the existence and uniquenessof steady states in this system, as well as local and global stability of these steady states.In particular, we identify parameter conditions for the stability of the system when negativefeedback loops are represented either as Hill functions, or in more general terms.Our results suggest that two factors -- autoregulation of the proliferation oftransit amplifying (TA) progenitor cells, and a low death rate of TD cells -- enhance the stability of this system.https://www.aimspress.com/article/doi/10.3934/mbe.2009.6.59cell lineageolfactoryepitheliumneurogenesisterminally differentiated cellfeedbacktransit amplifyingcellmodelingstabilityneuronal progenitorstem cell |
| spellingShingle | Wing-Cheong Lo Ching-Shan Chou Kimberly K. Gokoffski Frederic Y.-M. Wan Arthur D. Lander Anne L. Calof Qing Nie Feedback regulation in multistage cell lineages Mathematical Biosciences and Engineering cell lineage olfactoryepithelium neurogenesis terminally differentiated cell feedback transit amplifyingcell modeling stability neuronal progenitor stem cell |
| title | Feedback regulation in multistage cell lineages |
| title_full | Feedback regulation in multistage cell lineages |
| title_fullStr | Feedback regulation in multistage cell lineages |
| title_full_unstemmed | Feedback regulation in multistage cell lineages |
| title_short | Feedback regulation in multistage cell lineages |
| title_sort | feedback regulation in multistage cell lineages |
| topic | cell lineage olfactoryepithelium neurogenesis terminally differentiated cell feedback transit amplifyingcell modeling stability neuronal progenitor stem cell |
| url | https://www.aimspress.com/article/doi/10.3934/mbe.2009.6.59 |
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