Comparative Analysis of Acral Melanoma in Chinese and Caucasian Patients
Background. Acral melanoma (AM) is a rare subtype of melanoma, which is one of the least common in Caucasian patients but is a common subtype of melanoma in Chinese patients. It is unclear if prognosis differs between Chinese and Caucasian patients diagnosed with AM. The aim of our study is to inves...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Journal of Skin Cancer |
| Online Access: | http://dx.doi.org/10.1155/2020/5169051 |
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| _version_ | 1832566382599864320 |
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| author | Kai Huang Yu Xu Emmanuel M. Gabriel Subhasis Misra Yong Chen Sanjay P. Bagaria |
| author_facet | Kai Huang Yu Xu Emmanuel M. Gabriel Subhasis Misra Yong Chen Sanjay P. Bagaria |
| author_sort | Kai Huang |
| collection | DOAJ |
| description | Background. Acral melanoma (AM) is a rare subtype of melanoma, which is one of the least common in Caucasian patients but is a common subtype of melanoma in Chinese patients. It is unclear if prognosis differs between Chinese and Caucasian patients diagnosed with AM. The aim of our study is to investigate patient characteristics and survival differences between Chinese and Caucasian AM patients. Methods. Two large institutional melanoma databases from Fudan University Shanghai Cancer Center (FUSCC) and Mayo Clinic enterprise were retrospectively reviewed from 2009 to 2015. Clinicopathologic and survival data were collected and analyzed between the two groups. The primary outcome was disease-specific survival (DSS) and was calculated using the Kaplan Meier (KM) method. Results. The Chinese group presented with more advanced disease compared with Caucasians: thicker Breslow depth (median 3.0 mm vs. 1.2 mm, p=0.003), more ulcerated disease (66.1% vs. 29%; p<0.001), and advanced stages (stage II/III 84.3% vs. 37.1%; p<0.001). No significant difference was identified in terms of age at diagnosis, location, histologic subtypes, or node positive rate. The 5-year DSS rate was 68.4% and 73% (p=0.56) in Chinese and Caucasians AM patients, respectively. Male gender, Breslow thickness, ulceration, and positive sentinel lymph nodes were independent poor prognostic factors on multivariate analysis. Conclusions. There appears to be no difference in stage-stratified survival between Chinese and Caucasians, supporting the implementation of clinical trials for AM that could include both Chinese and Caucasian patients. |
| format | Article |
| id | doaj-art-fd4c55086aa24c289ea62e50628e8408 |
| institution | Kabale University |
| issn | 2090-2905 2090-2913 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Skin Cancer |
| spelling | doaj-art-fd4c55086aa24c289ea62e50628e84082025-02-03T01:04:25ZengWileyJournal of Skin Cancer2090-29052090-29132020-01-01202010.1155/2020/51690515169051Comparative Analysis of Acral Melanoma in Chinese and Caucasian PatientsKai Huang0Yu Xu1Emmanuel M. Gabriel2Subhasis Misra3Yong Chen4Sanjay P. Bagaria5Department of General Surgery, Brandon Regional Hospital, HCA Healthcare/USF Morsani College of Medicine, Brandon, FL, USADepartment of Musculoskeletal Oncology, Fudan University Shanghai Cancer Center, Shanghai, ChinaDepartment of General Surgery, Mayo Clinic Florida, Jacksonville, FL, USADepartment of General Surgery, Brandon Regional Hospital, HCA Healthcare/USF Morsani College of Medicine, Brandon, FL, USADepartment of Musculoskeletal Oncology, Fudan University Shanghai Cancer Center, Shanghai, ChinaDepartment of General Surgery, Mayo Clinic Florida, Jacksonville, FL, USABackground. Acral melanoma (AM) is a rare subtype of melanoma, which is one of the least common in Caucasian patients but is a common subtype of melanoma in Chinese patients. It is unclear if prognosis differs between Chinese and Caucasian patients diagnosed with AM. The aim of our study is to investigate patient characteristics and survival differences between Chinese and Caucasian AM patients. Methods. Two large institutional melanoma databases from Fudan University Shanghai Cancer Center (FUSCC) and Mayo Clinic enterprise were retrospectively reviewed from 2009 to 2015. Clinicopathologic and survival data were collected and analyzed between the two groups. The primary outcome was disease-specific survival (DSS) and was calculated using the Kaplan Meier (KM) method. Results. The Chinese group presented with more advanced disease compared with Caucasians: thicker Breslow depth (median 3.0 mm vs. 1.2 mm, p=0.003), more ulcerated disease (66.1% vs. 29%; p<0.001), and advanced stages (stage II/III 84.3% vs. 37.1%; p<0.001). No significant difference was identified in terms of age at diagnosis, location, histologic subtypes, or node positive rate. The 5-year DSS rate was 68.4% and 73% (p=0.56) in Chinese and Caucasians AM patients, respectively. Male gender, Breslow thickness, ulceration, and positive sentinel lymph nodes were independent poor prognostic factors on multivariate analysis. Conclusions. There appears to be no difference in stage-stratified survival between Chinese and Caucasians, supporting the implementation of clinical trials for AM that could include both Chinese and Caucasian patients.http://dx.doi.org/10.1155/2020/5169051 |
| spellingShingle | Kai Huang Yu Xu Emmanuel M. Gabriel Subhasis Misra Yong Chen Sanjay P. Bagaria Comparative Analysis of Acral Melanoma in Chinese and Caucasian Patients Journal of Skin Cancer |
| title | Comparative Analysis of Acral Melanoma in Chinese and Caucasian Patients |
| title_full | Comparative Analysis of Acral Melanoma in Chinese and Caucasian Patients |
| title_fullStr | Comparative Analysis of Acral Melanoma in Chinese and Caucasian Patients |
| title_full_unstemmed | Comparative Analysis of Acral Melanoma in Chinese and Caucasian Patients |
| title_short | Comparative Analysis of Acral Melanoma in Chinese and Caucasian Patients |
| title_sort | comparative analysis of acral melanoma in chinese and caucasian patients |
| url | http://dx.doi.org/10.1155/2020/5169051 |
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