Synthesis and Bioevaluation of Thieno[2,3-d]pyrimidinone Derivatives as Potential Tumor Cell Growth Inhibitors
A series of novel cycloalkylthieno[2,3-d]pyrimidinone derivatives have been conveniently synthesized via three steps including G-3CR, heterocyclization, and alkylation reactions as a part of our ongoing search for new bioactive molecules. The newly synthesized compounds were evaluated for their pote...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Journal of Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2013/692074 |
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| _version_ | 1832566728268185600 |
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| author | Huangyong Li Changshui Chen Shengzhen Xu Xiufang Cao |
| author_facet | Huangyong Li Changshui Chen Shengzhen Xu Xiufang Cao |
| author_sort | Huangyong Li |
| collection | DOAJ |
| description | A series of novel cycloalkylthieno[2,3-d]pyrimidinone derivatives have been conveniently synthesized via three steps including G-3CR, heterocyclization, and alkylation reactions as a part of our ongoing search for new bioactive molecules. The newly synthesized compounds were evaluated for their potential tumor cell growth inhibitory activity by standard MTT assay. The preliminary results show that compound 6b exhibited better inhibitory activities against HepG2, MCF-7, and BCG-823 cell lines compared to the control. |
| format | Article |
| id | doaj-art-fd45587b30c54666a310bdc8895c999f |
| institution | Kabale University |
| issn | 2090-9063 2090-9071 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Chemistry |
| spelling | doaj-art-fd45587b30c54666a310bdc8895c999f2025-02-03T01:03:30ZengWileyJournal of Chemistry2090-90632090-90712013-01-01201310.1155/2013/692074692074Synthesis and Bioevaluation of Thieno[2,3-d]pyrimidinone Derivatives as Potential Tumor Cell Growth InhibitorsHuangyong Li0Changshui Chen1Shengzhen Xu2Xiufang Cao3College of Science, Huazhong Agricultural University, Wuhan 430070, ChinaCollege of Science, Huazhong Agricultural University, Wuhan 430070, ChinaCollege of Science, Huazhong Agricultural University, Wuhan 430070, ChinaCollege of Science, Huazhong Agricultural University, Wuhan 430070, ChinaA series of novel cycloalkylthieno[2,3-d]pyrimidinone derivatives have been conveniently synthesized via three steps including G-3CR, heterocyclization, and alkylation reactions as a part of our ongoing search for new bioactive molecules. The newly synthesized compounds were evaluated for their potential tumor cell growth inhibitory activity by standard MTT assay. The preliminary results show that compound 6b exhibited better inhibitory activities against HepG2, MCF-7, and BCG-823 cell lines compared to the control.http://dx.doi.org/10.1155/2013/692074 |
| spellingShingle | Huangyong Li Changshui Chen Shengzhen Xu Xiufang Cao Synthesis and Bioevaluation of Thieno[2,3-d]pyrimidinone Derivatives as Potential Tumor Cell Growth Inhibitors Journal of Chemistry |
| title | Synthesis and Bioevaluation of Thieno[2,3-d]pyrimidinone Derivatives as Potential Tumor Cell Growth Inhibitors |
| title_full | Synthesis and Bioevaluation of Thieno[2,3-d]pyrimidinone Derivatives as Potential Tumor Cell Growth Inhibitors |
| title_fullStr | Synthesis and Bioevaluation of Thieno[2,3-d]pyrimidinone Derivatives as Potential Tumor Cell Growth Inhibitors |
| title_full_unstemmed | Synthesis and Bioevaluation of Thieno[2,3-d]pyrimidinone Derivatives as Potential Tumor Cell Growth Inhibitors |
| title_short | Synthesis and Bioevaluation of Thieno[2,3-d]pyrimidinone Derivatives as Potential Tumor Cell Growth Inhibitors |
| title_sort | synthesis and bioevaluation of thieno 2 3 d pyrimidinone derivatives as potential tumor cell growth inhibitors |
| url | http://dx.doi.org/10.1155/2013/692074 |
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