Pseudolumen Size and Perimeter in Prostate Cancer: Correlation with Patient Outcome
We demonstrated in 2011 that 61% of men with postoperative PSA failure had some cribriform pattern of prostate cancer, versus 16% of nonfailures ( OR=5.89, 𝑃<.0001). That study used digitized radical prostatectomy slides from 153 men, 76 fa...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | Prostate Cancer |
| Online Access: | http://dx.doi.org/10.1155/2011/693853 |
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| author | Kenneth A. Iczkowski Kathleen C. Torkko Gregory R. Kotnis R. Storey Wilson Wei Huang Thomas M. Wheeler Andrea M. Abeyta M. Scott Lucia |
| author_facet | Kenneth A. Iczkowski Kathleen C. Torkko Gregory R. Kotnis R. Storey Wilson Wei Huang Thomas M. Wheeler Andrea M. Abeyta M. Scott Lucia |
| author_sort | Kenneth A. Iczkowski |
| collection | DOAJ |
| description | We demonstrated in 2011 that 61% of men with postoperative PSA failure had some cribriform pattern of prostate cancer, versus 16% of nonfailures (
OR=5.89,
𝑃<.0001). That study used digitized radical prostatectomy slides from 153 men, 76 failures (≥0.2 ng/mL) matched to 77 nonfailures. The current study's hypothesis: pseudolumen size and shape variability could stratify outcome within histologic patterns (single separate acini, separate acini with undulating lumens, fused small acini, papillary, cribriform). Pseudolumens were filled digitally on image captures from previously annotated specimens. Among all 5 patterns, pseudolumen spaces averaged smaller in failures than nonfailures. After multivariate analysis controlling for stage, age, margin, cancer amount, prostate volume, and presence of individual cells (grade 5), this retained significance only for the undulating-lumens and papillary patterns. In undulating-lumens pattern, PSA failures had smaller mean pseudolumen space sizes (𝑃=.03) but larger perimeters (𝑃=.04), implying more pseudolumen irregularity. In papillary pattern, the number of pseudolumen spaces was higher in failures (𝑃=.015), space size was smaller (𝑃=.11), perimeters were smaller (𝑃=.04), and perimeter/size ratio was higher (𝑃=.02). In conclusion, digitally measured pseudolumen size and shape may associate with outcome. |
| format | Article |
| id | doaj-art-fd376c8e8db24455b59a243e0249167b |
| institution | Kabale University |
| issn | 2090-3111 2090-312X |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Prostate Cancer |
| spelling | doaj-art-fd376c8e8db24455b59a243e0249167b2025-02-03T00:59:09ZengWileyProstate Cancer2090-31112090-312X2011-01-01201110.1155/2011/693853693853Pseudolumen Size and Perimeter in Prostate Cancer: Correlation with Patient OutcomeKenneth A. Iczkowski0Kathleen C. Torkko1Gregory R. Kotnis2R. Storey Wilson3Wei Huang4Thomas M. Wheeler5Andrea M. Abeyta6M. Scott Lucia7Department of Pathology, University of Colorado Denver School of Medicine, Aurora, CO 80045, USADepartment of Pathology, University of Colorado Denver School of Medicine, Aurora, CO 80045, USADepartment of Pathology, University of Colorado Denver School of Medicine, Aurora, CO 80045, USADepartment of Pathology, University of Colorado Denver School of Medicine, Aurora, CO 80045, USADepartment of Pathology and Laboratory Medicine, University of Wisconsin, Madison, WI 53792, USADepartment of Pathology and Immunology, Baylor College of Medicine, Houston, TX 77030, USADepartment of Pathology, University of Colorado Denver School of Medicine, Aurora, CO 80045, USADepartment of Pathology, University of Colorado Denver School of Medicine, Aurora, CO 80045, USAWe demonstrated in 2011 that 61% of men with postoperative PSA failure had some cribriform pattern of prostate cancer, versus 16% of nonfailures ( OR=5.89, 𝑃<.0001). That study used digitized radical prostatectomy slides from 153 men, 76 failures (≥0.2 ng/mL) matched to 77 nonfailures. The current study's hypothesis: pseudolumen size and shape variability could stratify outcome within histologic patterns (single separate acini, separate acini with undulating lumens, fused small acini, papillary, cribriform). Pseudolumens were filled digitally on image captures from previously annotated specimens. Among all 5 patterns, pseudolumen spaces averaged smaller in failures than nonfailures. After multivariate analysis controlling for stage, age, margin, cancer amount, prostate volume, and presence of individual cells (grade 5), this retained significance only for the undulating-lumens and papillary patterns. In undulating-lumens pattern, PSA failures had smaller mean pseudolumen space sizes (𝑃=.03) but larger perimeters (𝑃=.04), implying more pseudolumen irregularity. In papillary pattern, the number of pseudolumen spaces was higher in failures (𝑃=.015), space size was smaller (𝑃=.11), perimeters were smaller (𝑃=.04), and perimeter/size ratio was higher (𝑃=.02). In conclusion, digitally measured pseudolumen size and shape may associate with outcome.http://dx.doi.org/10.1155/2011/693853 |
| spellingShingle | Kenneth A. Iczkowski Kathleen C. Torkko Gregory R. Kotnis R. Storey Wilson Wei Huang Thomas M. Wheeler Andrea M. Abeyta M. Scott Lucia Pseudolumen Size and Perimeter in Prostate Cancer: Correlation with Patient Outcome Prostate Cancer |
| title | Pseudolumen Size and Perimeter in Prostate Cancer: Correlation with Patient Outcome |
| title_full | Pseudolumen Size and Perimeter in Prostate Cancer: Correlation with Patient Outcome |
| title_fullStr | Pseudolumen Size and Perimeter in Prostate Cancer: Correlation with Patient Outcome |
| title_full_unstemmed | Pseudolumen Size and Perimeter in Prostate Cancer: Correlation with Patient Outcome |
| title_short | Pseudolumen Size and Perimeter in Prostate Cancer: Correlation with Patient Outcome |
| title_sort | pseudolumen size and perimeter in prostate cancer correlation with patient outcome |
| url | http://dx.doi.org/10.1155/2011/693853 |
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