Brain‐Derived Neurotrophic Factor (BDNF) as a Potential Biomarker in Brain Glioma: A Systematic Review and Meta‐Analysis
ABSTRACT Background This systematic review and meta‐analysis evaluates peripheral and CNS BDNF levels in glioma patients. Methods Following PRISMA guidelines, we systematically searched databases for studies measuring BDNF in glioma patients and controls. After screening and data extraction, we cond...
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| Format: | Article |
| Language: | English |
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Wiley
2025-01-01
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| Series: | Brain and Behavior |
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| Online Access: | https://doi.org/10.1002/brb3.70266 |
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| author | Fatemeh Hasani Mahdi Masrour Sina Khamaki Kimia Jazi Erfan Ghoodjani Antonio L. Teixeira |
| author_facet | Fatemeh Hasani Mahdi Masrour Sina Khamaki Kimia Jazi Erfan Ghoodjani Antonio L. Teixeira |
| author_sort | Fatemeh Hasani |
| collection | DOAJ |
| description | ABSTRACT Background This systematic review and meta‐analysis evaluates peripheral and CNS BDNF levels in glioma patients. Methods Following PRISMA guidelines, we systematically searched databases for studies measuring BDNF in glioma patients and controls. After screening and data extraction, we conducted quality assessment, meta‐analysis, and meta‐regression. Results Eight studies were included. Meta‐analysis showed significantly reduced plasma BDNF levels in glioma patients versus controls (SMD: −1.0026; 95% CI: [−1.5284, −0.4769], p = 0.0002). High‐grade gliomas had lower plasma BDNF (p = 0.0288). Tissue BDNF levels were higher in glioma patients (SMD: 1.9513; 95% CI: [0.7365, 3.1661], p = 0.0016) and correlated with tumor grade (p = 0.0122). Plasma BDNF levels negatively correlated with patient age (p = 0.0244) and positively with female percentage (p = 0.0007). Conclusion BDNF is a promising biomarker in glioma, showing significant changes in plasma and tissue levels correlating with tumor grade, patient age, and gender. |
| format | Article |
| id | doaj-art-fd322da6e7e64ef4b71d69762cc31ed5 |
| institution | Kabale University |
| issn | 2162-3279 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Brain and Behavior |
| spelling | doaj-art-fd322da6e7e64ef4b71d69762cc31ed52025-01-29T13:36:39ZengWileyBrain and Behavior2162-32792025-01-01151n/an/a10.1002/brb3.70266Brain‐Derived Neurotrophic Factor (BDNF) as a Potential Biomarker in Brain Glioma: A Systematic Review and Meta‐AnalysisFatemeh Hasani0Mahdi Masrour1Sina Khamaki2Kimia Jazi3Erfan Ghoodjani4Antonio L. Teixeira5Gastroenterology and Hepatology Research Center Golestan University of Medical Sciences Gorgan IranSchool of Medicine Tehran University of Medical Sciences Tehran IranGastroenterology and Hepatology Research Center Golestan University of Medical Sciences Gorgan IranStudent Research Committee, Faculty of Medicine Medical University of Qom Qom IranSchool of Medicine Isfahan University of Medical Sciences Isfahan IranBiggs Institute The University of Texas Health Science Center at San Antonio San Antonio Texas USAABSTRACT Background This systematic review and meta‐analysis evaluates peripheral and CNS BDNF levels in glioma patients. Methods Following PRISMA guidelines, we systematically searched databases for studies measuring BDNF in glioma patients and controls. After screening and data extraction, we conducted quality assessment, meta‐analysis, and meta‐regression. Results Eight studies were included. Meta‐analysis showed significantly reduced plasma BDNF levels in glioma patients versus controls (SMD: −1.0026; 95% CI: [−1.5284, −0.4769], p = 0.0002). High‐grade gliomas had lower plasma BDNF (p = 0.0288). Tissue BDNF levels were higher in glioma patients (SMD: 1.9513; 95% CI: [0.7365, 3.1661], p = 0.0016) and correlated with tumor grade (p = 0.0122). Plasma BDNF levels negatively correlated with patient age (p = 0.0244) and positively with female percentage (p = 0.0007). Conclusion BDNF is a promising biomarker in glioma, showing significant changes in plasma and tissue levels correlating with tumor grade, patient age, and gender.https://doi.org/10.1002/brb3.70266BDNFbiomarkerbrain neoplasmsbrain‐derived neurotrophic factorglioblastomaglioma |
| spellingShingle | Fatemeh Hasani Mahdi Masrour Sina Khamaki Kimia Jazi Erfan Ghoodjani Antonio L. Teixeira Brain‐Derived Neurotrophic Factor (BDNF) as a Potential Biomarker in Brain Glioma: A Systematic Review and Meta‐Analysis Brain and Behavior BDNF biomarker brain neoplasms brain‐derived neurotrophic factor glioblastoma glioma |
| title | Brain‐Derived Neurotrophic Factor (BDNF) as a Potential Biomarker in Brain Glioma: A Systematic Review and Meta‐Analysis |
| title_full | Brain‐Derived Neurotrophic Factor (BDNF) as a Potential Biomarker in Brain Glioma: A Systematic Review and Meta‐Analysis |
| title_fullStr | Brain‐Derived Neurotrophic Factor (BDNF) as a Potential Biomarker in Brain Glioma: A Systematic Review and Meta‐Analysis |
| title_full_unstemmed | Brain‐Derived Neurotrophic Factor (BDNF) as a Potential Biomarker in Brain Glioma: A Systematic Review and Meta‐Analysis |
| title_short | Brain‐Derived Neurotrophic Factor (BDNF) as a Potential Biomarker in Brain Glioma: A Systematic Review and Meta‐Analysis |
| title_sort | brain derived neurotrophic factor bdnf as a potential biomarker in brain glioma a systematic review and meta analysis |
| topic | BDNF biomarker brain neoplasms brain‐derived neurotrophic factor glioblastoma glioma |
| url | https://doi.org/10.1002/brb3.70266 |
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