Super-Refractory Status Epilepticus Treated with High Dose Perampanel: Case Series and Review of the Literature
Introduction. Acute symptomatic seizures are frequent in the critically ill patient and can be difficult to treat. The novel anticonvulsant perampanel may be effective in the treatment of status epilepticus considering its mechanism of action of being an AMPA antagonist. We present four cases of sup...
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | Case Reports in Critical Care |
| Online Access: | http://dx.doi.org/10.1155/2019/3218231 |
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| author | Christopher R. Newey Naresh Mullaguri Stephen Hantus Vineet Punia Pravin George |
| author_facet | Christopher R. Newey Naresh Mullaguri Stephen Hantus Vineet Punia Pravin George |
| author_sort | Christopher R. Newey |
| collection | DOAJ |
| description | Introduction. Acute symptomatic seizures are frequent in the critically ill patient and can be difficult to treat. The novel anticonvulsant perampanel may be effective in the treatment of status epilepticus considering its mechanism of action of being an AMPA antagonist. We present four cases of super refractory status epilepticus treated with high dose perampanel. Method. Case report. Cases. Four patients were treated with perampanel for their refractory status epilepticus. One patient had new onset refractory status epilepticus of unknown etiology. Three other patients had status epilepticus as a result of their cardiac arrest. Two of the cardiac arrest patients had myoclonus. In all patients, the additional of perampanel resulted in a reduction of seizure burden without affecting hemodynamics or hepatic or renal function. Conclusion. Perampanel may be effective in the treatment of super-refractory status epilepticus of varying etiologies. A larger, prospective study is needed to further assess this therapy. |
| format | Article |
| id | doaj-art-fd226cc2b3694da282a41f93f6eaca57 |
| institution | Kabale University |
| issn | 2090-6420 2090-6439 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Critical Care |
| spelling | doaj-art-fd226cc2b3694da282a41f93f6eaca572025-02-03T05:50:24ZengWileyCase Reports in Critical Care2090-64202090-64392019-01-01201910.1155/2019/32182313218231Super-Refractory Status Epilepticus Treated with High Dose Perampanel: Case Series and Review of the LiteratureChristopher R. Newey0Naresh Mullaguri1Stephen Hantus2Vineet Punia3Pravin George4Cerebrovascular Center, Neurological Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USACerebrovascular Center, Neurological Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USACerebrovascular Center, Neurological Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USAEpilepsy Center, Neurological Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USACerebrovascular Center, Neurological Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USAIntroduction. Acute symptomatic seizures are frequent in the critically ill patient and can be difficult to treat. The novel anticonvulsant perampanel may be effective in the treatment of status epilepticus considering its mechanism of action of being an AMPA antagonist. We present four cases of super refractory status epilepticus treated with high dose perampanel. Method. Case report. Cases. Four patients were treated with perampanel for their refractory status epilepticus. One patient had new onset refractory status epilepticus of unknown etiology. Three other patients had status epilepticus as a result of their cardiac arrest. Two of the cardiac arrest patients had myoclonus. In all patients, the additional of perampanel resulted in a reduction of seizure burden without affecting hemodynamics or hepatic or renal function. Conclusion. Perampanel may be effective in the treatment of super-refractory status epilepticus of varying etiologies. A larger, prospective study is needed to further assess this therapy.http://dx.doi.org/10.1155/2019/3218231 |
| spellingShingle | Christopher R. Newey Naresh Mullaguri Stephen Hantus Vineet Punia Pravin George Super-Refractory Status Epilepticus Treated with High Dose Perampanel: Case Series and Review of the Literature Case Reports in Critical Care |
| title | Super-Refractory Status Epilepticus Treated with High Dose Perampanel: Case Series and Review of the Literature |
| title_full | Super-Refractory Status Epilepticus Treated with High Dose Perampanel: Case Series and Review of the Literature |
| title_fullStr | Super-Refractory Status Epilepticus Treated with High Dose Perampanel: Case Series and Review of the Literature |
| title_full_unstemmed | Super-Refractory Status Epilepticus Treated with High Dose Perampanel: Case Series and Review of the Literature |
| title_short | Super-Refractory Status Epilepticus Treated with High Dose Perampanel: Case Series and Review of the Literature |
| title_sort | super refractory status epilepticus treated with high dose perampanel case series and review of the literature |
| url | http://dx.doi.org/10.1155/2019/3218231 |
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