miR-16-1 Promotes the Aberrant α-Synuclein Accumulation in Parkinson Disease via Targeting Heat Shock Protein 70
There is striking evidence that heat shock protein 70 (Hsp70) negatively regulates α-synuclein aggregation, which plays a significant role in the formation and progression of Parkinson disease (PD). However, how the Hsp70 in neurons fails to prevent or even reverse α-synuclein aggregation and toxici...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1155/2014/938348 |
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| author | Zhelin Zhang Yan Cheng |
| author_facet | Zhelin Zhang Yan Cheng |
| author_sort | Zhelin Zhang |
| collection | DOAJ |
| description | There is striking evidence that heat shock protein 70 (Hsp70) negatively regulates α-synuclein aggregation, which plays a significant role in the formation and progression of Parkinson disease (PD). However, how the Hsp70 in neurons fails to prevent or even reverse α-synuclein aggregation and toxicity in PD still remains to be determined. In the present study, we constructed an α-synuclein-overexpressed human neuroblastoma cell line, SH-SY5Y-Syn, in which the blockage of Hsp70 promoted α-synuclein aggregation. And we also found that miR-16-1 downregulated Hsp70 and promoted α-synuclein aggregation in the SH-SY5Y-Syn cells. This study revealed a novel regulatory mechanism of Hsp70 expression, which might contribute to the PD development. |
| format | Article |
| id | doaj-art-fcf4dea1bc93467cba9c8d6b557236b3 |
| institution | Kabale University |
| issn | 2356-6140 1537-744X |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-fcf4dea1bc93467cba9c8d6b557236b32025-02-03T05:43:37ZengWileyThe Scientific World Journal2356-61401537-744X2014-01-01201410.1155/2014/938348938348miR-16-1 Promotes the Aberrant α-Synuclein Accumulation in Parkinson Disease via Targeting Heat Shock Protein 70Zhelin Zhang0Yan Cheng1Department of Neurology, General Hospital of Tianjin Medical University, No. 154, Anshan road, Heping District, Tianjin 300071, ChinaDepartment of Neurology, General Hospital of Tianjin Medical University, No. 154, Anshan road, Heping District, Tianjin 300071, ChinaThere is striking evidence that heat shock protein 70 (Hsp70) negatively regulates α-synuclein aggregation, which plays a significant role in the formation and progression of Parkinson disease (PD). However, how the Hsp70 in neurons fails to prevent or even reverse α-synuclein aggregation and toxicity in PD still remains to be determined. In the present study, we constructed an α-synuclein-overexpressed human neuroblastoma cell line, SH-SY5Y-Syn, in which the blockage of Hsp70 promoted α-synuclein aggregation. And we also found that miR-16-1 downregulated Hsp70 and promoted α-synuclein aggregation in the SH-SY5Y-Syn cells. This study revealed a novel regulatory mechanism of Hsp70 expression, which might contribute to the PD development.http://dx.doi.org/10.1155/2014/938348 |
| spellingShingle | Zhelin Zhang Yan Cheng miR-16-1 Promotes the Aberrant α-Synuclein Accumulation in Parkinson Disease via Targeting Heat Shock Protein 70 The Scientific World Journal |
| title | miR-16-1 Promotes the Aberrant α-Synuclein Accumulation in Parkinson Disease via Targeting Heat Shock Protein 70 |
| title_full | miR-16-1 Promotes the Aberrant α-Synuclein Accumulation in Parkinson Disease via Targeting Heat Shock Protein 70 |
| title_fullStr | miR-16-1 Promotes the Aberrant α-Synuclein Accumulation in Parkinson Disease via Targeting Heat Shock Protein 70 |
| title_full_unstemmed | miR-16-1 Promotes the Aberrant α-Synuclein Accumulation in Parkinson Disease via Targeting Heat Shock Protein 70 |
| title_short | miR-16-1 Promotes the Aberrant α-Synuclein Accumulation in Parkinson Disease via Targeting Heat Shock Protein 70 |
| title_sort | mir 16 1 promotes the aberrant α synuclein accumulation in parkinson disease via targeting heat shock protein 70 |
| url | http://dx.doi.org/10.1155/2014/938348 |
| work_keys_str_mv | AT zhelinzhang mir161promotestheaberrantasynucleinaccumulationinparkinsondiseaseviatargetingheatshockprotein70 AT yancheng mir161promotestheaberrantasynucleinaccumulationinparkinsondiseaseviatargetingheatshockprotein70 |