Mesenchymal Progenitor Cells and Their Orthopedic Applications: Forging a Path towards Clinical Trials
Mesenchymal progenitor cells (MPCs) are nonhematopoietic multipotent cells capable of differentiating into mesenchymal and nonmesenchymal lineages. While they can be isolated from various tissues, MPCs isolated from the bone marrow are best characterized. These cells represent a subset of bone marro...
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| Format: | Article |
| Language: | English |
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Wiley
2010-01-01
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| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.4061/2010/519028 |
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| author | Deana S. Shenaq Farbod Rastegar Djuro Petkovic Bing-Qiang Zhang Bai-Cheng He Liang Chen Guo-Wei Zuo Qing Luo Qiong Shi Eric R. Wagner Enyi Huang Yanhong Gao Jian-Li Gao Stephanie H. Kim Ke Yang Yang Bi Yuxi Su Gaohui Zhu Jinyong Luo Xiaoji Luo Jiaqiang Qin Russell R. Reid Hue H. Luu Rex C. Haydon Tong-Chuan He |
| author_facet | Deana S. Shenaq Farbod Rastegar Djuro Petkovic Bing-Qiang Zhang Bai-Cheng He Liang Chen Guo-Wei Zuo Qing Luo Qiong Shi Eric R. Wagner Enyi Huang Yanhong Gao Jian-Li Gao Stephanie H. Kim Ke Yang Yang Bi Yuxi Su Gaohui Zhu Jinyong Luo Xiaoji Luo Jiaqiang Qin Russell R. Reid Hue H. Luu Rex C. Haydon Tong-Chuan He |
| author_sort | Deana S. Shenaq |
| collection | DOAJ |
| description | Mesenchymal progenitor cells (MPCs) are nonhematopoietic multipotent cells capable of differentiating into mesenchymal and nonmesenchymal lineages. While they can be isolated from various tissues, MPCs isolated from the bone marrow are best characterized. These cells represent a subset of bone marrow stromal cells (BMSCs) which, in addition to their differentiation potential, are critical in supporting proliferation and differentiation of hematopoietic cells. They are of clinical interest because they can be easily isolated from bone marrow aspirates and expanded in vitro with minimal donor site morbidity. The BMSCs are also capable of altering disease pathophysiology by secreting modulating factors in a paracrine manner. Thus, engineering such cells to maximize therapeutic potential has been the focus of cell/gene therapy to date. Here, we discuss the path towards the development of clinical trials utilizing BMSCs for orthopaedic applications. Specifically, we will review the use of BMSCs in repairing critical-sized defects, fracture nonunions, cartilage and tendon injuries, as well as in metabolic bone diseases and osteonecrosis. A review of www.ClinicalTrials.gov of the United States National Institute of Health was performed, and ongoing clinical trials will be discussed in addition to the sentinel preclinical studies that paved the way for human investigations. |
| format | Article |
| id | doaj-art-fcdb5cfdb2334aeb974014d7b7825b75 |
| institution | Kabale University |
| issn | 1687-9678 |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-fcdb5cfdb2334aeb974014d7b7825b752025-02-03T01:24:05ZengWileyStem Cells International1687-96782010-01-01201010.4061/2010/519028519028Mesenchymal Progenitor Cells and Their Orthopedic Applications: Forging a Path towards Clinical TrialsDeana S. Shenaq0Farbod Rastegar1Djuro Petkovic2Bing-Qiang Zhang3Bai-Cheng He4Liang Chen5Guo-Wei Zuo6Qing Luo7Qiong Shi8Eric R. Wagner9Enyi Huang10Yanhong Gao11Jian-Li Gao12Stephanie H. Kim13Ke Yang14Yang Bi15Yuxi Su16Gaohui Zhu17Jinyong Luo18Xiaoji Luo19Jiaqiang Qin20Russell R. Reid21Hue H. Luu22Rex C. Haydon23Tong-Chuan He24Molecular Oncology Laboratory, Department of Surgery, The University of Chicago Medical Center, 5841 South Maryland Avenue, MC3079, Chicago, IL 60637, USAMolecular Oncology Laboratory, Department of Surgery, The University of Chicago Medical Center, 5841 South Maryland Avenue, MC3079, Chicago, IL 60637, USAMolecular Oncology Laboratory, Department of Surgery, The University of Chicago Medical Center, 5841 South Maryland Avenue, MC3079, Chicago, IL 60637, USAMolecular Oncology Laboratory, Department of Surgery, The University of Chicago Medical Center, 5841 South Maryland Avenue, MC3079, Chicago, IL 60637, USAMolecular Oncology Laboratory, Department of Surgery, The University of Chicago Medical Center, 5841 South Maryland Avenue, MC3079, Chicago, IL 60637, USAMolecular Oncology Laboratory, Department of Surgery, The University of Chicago Medical Center, 5841 South Maryland Avenue, MC3079, Chicago, IL 60637, USAMolecular Oncology Laboratory, Department of Surgery, The University of Chicago Medical Center, 5841 South Maryland Avenue, MC3079, Chicago, IL 60637, USAMolecular Oncology Laboratory, Department of Surgery, The University of Chicago Medical Center, 5841 South Maryland Avenue, MC3079, Chicago, IL 60637, USAMolecular Oncology Laboratory, Department of Surgery, The University of Chicago Medical Center, 5841 South Maryland Avenue, MC3079, Chicago, IL 60637, USAMolecular Oncology Laboratory, Department of Surgery, The University of Chicago Medical Center, 5841 South Maryland Avenue, MC3079, Chicago, IL 60637, USAMolecular Oncology Laboratory, Department of Surgery, The University of Chicago Medical Center, 5841 South Maryland Avenue, MC3079, Chicago, IL 60637, USAMolecular Oncology Laboratory, Department of Surgery, The University of Chicago Medical Center, 5841 South Maryland Avenue, MC3079, Chicago, IL 60637, USAMolecular Oncology Laboratory, Department of Surgery, The University of Chicago Medical Center, 5841 South Maryland Avenue, MC3079, Chicago, IL 60637, USAMolecular Oncology Laboratory, Department of Surgery, The University of Chicago Medical Center, 5841 South Maryland Avenue, MC3079, Chicago, IL 60637, USAMolecular Oncology Laboratory, Department of Surgery, The University of Chicago Medical Center, 5841 South Maryland Avenue, MC3079, Chicago, IL 60637, USAMolecular Oncology Laboratory, Department of Surgery, The University of Chicago Medical Center, 5841 South Maryland Avenue, MC3079, Chicago, IL 60637, USAMolecular Oncology Laboratory, Department of Surgery, The University of Chicago Medical Center, 5841 South Maryland Avenue, MC3079, Chicago, IL 60637, USAMolecular Oncology Laboratory, Department of Surgery, The University of Chicago Medical Center, 5841 South Maryland Avenue, MC3079, Chicago, IL 60637, USAMolecular Oncology Laboratory, Department of Surgery, The University of Chicago Medical Center, 5841 South Maryland Avenue, MC3079, Chicago, IL 60637, USAMolecular Oncology Laboratory, Department of Surgery, The University of Chicago Medical Center, 5841 South Maryland Avenue, MC3079, Chicago, IL 60637, USAMolecular Oncology Laboratory, Department of Surgery, The University of Chicago Medical Center, 5841 South Maryland Avenue, MC3079, Chicago, IL 60637, USAMolecular Oncology Laboratory, Department of Surgery, The University of Chicago Medical Center, 5841 South Maryland Avenue, MC3079, Chicago, IL 60637, USAMolecular Oncology Laboratory, Department of Surgery, The University of Chicago Medical Center, 5841 South Maryland Avenue, MC3079, Chicago, IL 60637, USAMolecular Oncology Laboratory, Department of Surgery, The University of Chicago Medical Center, 5841 South Maryland Avenue, MC3079, Chicago, IL 60637, USAMolecular Oncology Laboratory, Department of Surgery, The University of Chicago Medical Center, 5841 South Maryland Avenue, MC3079, Chicago, IL 60637, USAMesenchymal progenitor cells (MPCs) are nonhematopoietic multipotent cells capable of differentiating into mesenchymal and nonmesenchymal lineages. While they can be isolated from various tissues, MPCs isolated from the bone marrow are best characterized. These cells represent a subset of bone marrow stromal cells (BMSCs) which, in addition to their differentiation potential, are critical in supporting proliferation and differentiation of hematopoietic cells. They are of clinical interest because they can be easily isolated from bone marrow aspirates and expanded in vitro with minimal donor site morbidity. The BMSCs are also capable of altering disease pathophysiology by secreting modulating factors in a paracrine manner. Thus, engineering such cells to maximize therapeutic potential has been the focus of cell/gene therapy to date. Here, we discuss the path towards the development of clinical trials utilizing BMSCs for orthopaedic applications. Specifically, we will review the use of BMSCs in repairing critical-sized defects, fracture nonunions, cartilage and tendon injuries, as well as in metabolic bone diseases and osteonecrosis. A review of www.ClinicalTrials.gov of the United States National Institute of Health was performed, and ongoing clinical trials will be discussed in addition to the sentinel preclinical studies that paved the way for human investigations.http://dx.doi.org/10.4061/2010/519028 |
| spellingShingle | Deana S. Shenaq Farbod Rastegar Djuro Petkovic Bing-Qiang Zhang Bai-Cheng He Liang Chen Guo-Wei Zuo Qing Luo Qiong Shi Eric R. Wagner Enyi Huang Yanhong Gao Jian-Li Gao Stephanie H. Kim Ke Yang Yang Bi Yuxi Su Gaohui Zhu Jinyong Luo Xiaoji Luo Jiaqiang Qin Russell R. Reid Hue H. Luu Rex C. Haydon Tong-Chuan He Mesenchymal Progenitor Cells and Their Orthopedic Applications: Forging a Path towards Clinical Trials Stem Cells International |
| title | Mesenchymal Progenitor Cells and Their Orthopedic Applications: Forging a Path towards Clinical Trials |
| title_full | Mesenchymal Progenitor Cells and Their Orthopedic Applications: Forging a Path towards Clinical Trials |
| title_fullStr | Mesenchymal Progenitor Cells and Their Orthopedic Applications: Forging a Path towards Clinical Trials |
| title_full_unstemmed | Mesenchymal Progenitor Cells and Their Orthopedic Applications: Forging a Path towards Clinical Trials |
| title_short | Mesenchymal Progenitor Cells and Their Orthopedic Applications: Forging a Path towards Clinical Trials |
| title_sort | mesenchymal progenitor cells and their orthopedic applications forging a path towards clinical trials |
| url | http://dx.doi.org/10.4061/2010/519028 |
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