High Salt Intake Increases Copeptin but Salt Sensitivity Is Associated with Fluid Induced Reduction of Copeptin in Women
This study investigated if copeptin is affected by high salt intake and whether any salt-induced changes in copeptin are related to the degree of salt sensitivity. The study was performed on 20 men and 19 women. In addition to meals containing 50 mmol NaCl daily, capsules containing 100 mmol NaCl an...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | International Journal of Hypertension |
| Online Access: | http://dx.doi.org/10.1155/2014/641587 |
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| author | Irina Tasevska Sofia Enhörning Philippe Burri Olle Melander |
| author_facet | Irina Tasevska Sofia Enhörning Philippe Burri Olle Melander |
| author_sort | Irina Tasevska |
| collection | DOAJ |
| description | This study investigated if copeptin is affected by high salt intake and whether any salt-induced changes in copeptin are related to the degree of salt sensitivity. The study was performed on 20 men and 19 women. In addition to meals containing 50 mmol NaCl daily, capsules containing 100 mmol NaCl and corresponding placebo capsules were administered during 4 weeks each, in random order. Measurements of 24 h blood pressure, body weight, 24 h urinary volume, and fasting plasma copeptin were performed at high and low salt consumption. Copeptin increased after a high compared to low dietary salt consumption in all subjects 3,59 ± 2,28 versus 3,12 ± 1,95 (P = 0,02). Copeptin correlated inversely with urinary volume, at both low (r = −0,42; P = 0,001) and high (r = −0,60; P < 0,001) salt consumption, as well as with the change in body weight (r = −0,53; P < 0,001). Systolic salt sensitivity was inversely correlated with salt-induced changes of copeptin, only in females (r = −0,58; P = 0,017). As suppression of copeptin on high versus low salt intake was associated with systolic salt sensitivity in women, our data suggest that high fluid intake and fluid retention may contribute to salt sensitivity. |
| format | Article |
| id | doaj-art-fcd9d300c55f436f99423c30592678ff |
| institution | Kabale University |
| issn | 2090-0384 2090-0392 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Hypertension |
| spelling | doaj-art-fcd9d300c55f436f99423c30592678ff2025-02-03T06:06:14ZengWileyInternational Journal of Hypertension2090-03842090-03922014-01-01201410.1155/2014/641587641587High Salt Intake Increases Copeptin but Salt Sensitivity Is Associated with Fluid Induced Reduction of Copeptin in WomenIrina Tasevska0Sofia Enhörning1Philippe Burri2Olle Melander3Department of Internal Medicine, Skåne University Hospital, 20502 Malmö, SwedenDepartment of Internal Medicine, Skåne University Hospital, 20502 Malmö, SwedenDepartment of Internal Medicine, Skåne University Hospital, 20502 Malmö, SwedenDepartment of Internal Medicine, Skåne University Hospital, 20502 Malmö, SwedenThis study investigated if copeptin is affected by high salt intake and whether any salt-induced changes in copeptin are related to the degree of salt sensitivity. The study was performed on 20 men and 19 women. In addition to meals containing 50 mmol NaCl daily, capsules containing 100 mmol NaCl and corresponding placebo capsules were administered during 4 weeks each, in random order. Measurements of 24 h blood pressure, body weight, 24 h urinary volume, and fasting plasma copeptin were performed at high and low salt consumption. Copeptin increased after a high compared to low dietary salt consumption in all subjects 3,59 ± 2,28 versus 3,12 ± 1,95 (P = 0,02). Copeptin correlated inversely with urinary volume, at both low (r = −0,42; P = 0,001) and high (r = −0,60; P < 0,001) salt consumption, as well as with the change in body weight (r = −0,53; P < 0,001). Systolic salt sensitivity was inversely correlated with salt-induced changes of copeptin, only in females (r = −0,58; P = 0,017). As suppression of copeptin on high versus low salt intake was associated with systolic salt sensitivity in women, our data suggest that high fluid intake and fluid retention may contribute to salt sensitivity.http://dx.doi.org/10.1155/2014/641587 |
| spellingShingle | Irina Tasevska Sofia Enhörning Philippe Burri Olle Melander High Salt Intake Increases Copeptin but Salt Sensitivity Is Associated with Fluid Induced Reduction of Copeptin in Women International Journal of Hypertension |
| title | High Salt Intake Increases Copeptin but Salt Sensitivity Is Associated with Fluid Induced Reduction of Copeptin in Women |
| title_full | High Salt Intake Increases Copeptin but Salt Sensitivity Is Associated with Fluid Induced Reduction of Copeptin in Women |
| title_fullStr | High Salt Intake Increases Copeptin but Salt Sensitivity Is Associated with Fluid Induced Reduction of Copeptin in Women |
| title_full_unstemmed | High Salt Intake Increases Copeptin but Salt Sensitivity Is Associated with Fluid Induced Reduction of Copeptin in Women |
| title_short | High Salt Intake Increases Copeptin but Salt Sensitivity Is Associated with Fluid Induced Reduction of Copeptin in Women |
| title_sort | high salt intake increases copeptin but salt sensitivity is associated with fluid induced reduction of copeptin in women |
| url | http://dx.doi.org/10.1155/2014/641587 |
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