Liposomal encapsulation of cholecalciferol mitigates in vivo toxicity and delays tumor growth

Liposomal encapsulation of cholecalciferol mitigates in vivo toxicity and delays tumor growth

IntroductionVitamin D3 (cholecalciferol) has demonstrated potential anticancer properties, but its clinical application is limited by associated toxicity at effective doses. This study investigated the use of liposomal encapsulation to increase the therapeutic efficacy of vitamin D3 while mitigating...

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Main Authors: Miriam Ezcurra-Hualde, Sara Zalba, Ángela Bella, Leire Arrizabalaga, Aline Risson, Román García-Fuentes, Celia Gomar, Nuria Ardaiz, Virginia Belsue, David Ruiz-Guillamon, Alejandro Serrano-Alcaide, Ainara Salgado, Fernando Aranda, Maria J. Garrido, Pedro Berraondo
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-01-01
Series:Frontiers in Immunology
Subjects:
liposomal encapsulation
vitamin D3
anticancer efficacy
gene expression
tumor growth
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1529007/full
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