Genomic diversity and evolutionary dynamics of Influenza A viruses in Colombian swine: implications for one health surveillance and control
Influenza A viruses (IAV) impose significant respiratory disease burdens in both swine and humans worldwide, with frequent human-to-swine transmission driving viral evolution in pigs and highlighting the risk at the animal-human interface. Therefore, a comprehensive One Health approach (interconnect...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2024-12-01
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| Series: | Emerging Microbes and Infections |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/22221751.2024.2368202 |
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| author | Karl Ciuoderis Jaime Usuga Laura S. Pérez-Restrepo Manuel Gonzalez-Ramirez Leidi Carvajal Andrés Cardona Isabel Moreno Andrés Diaz Mario Peña Juan P. Hernández-Ortiz Jorge E. Osorio |
| author_facet | Karl Ciuoderis Jaime Usuga Laura S. Pérez-Restrepo Manuel Gonzalez-Ramirez Leidi Carvajal Andrés Cardona Isabel Moreno Andrés Diaz Mario Peña Juan P. Hernández-Ortiz Jorge E. Osorio |
| author_sort | Karl Ciuoderis |
| collection | DOAJ |
| description | Influenza A viruses (IAV) impose significant respiratory disease burdens in both swine and humans worldwide, with frequent human-to-swine transmission driving viral evolution in pigs and highlighting the risk at the animal-human interface. Therefore, a comprehensive One Health approach (interconnection among human, animal, and environmental health) is needed for IAV prevention, control, and response. Animal influenza genomic surveillance remains limited in many Latin American countries, including Colombia. To address this gap, we genetically characterized 170 swine specimens from Colombia (2011–2017). Whole genome sequencing revealed a predominance of pandemic-like H1N1 lineage, with a minority belonging to H3N2 and H1N2 human seasonal-like lineage and H1N1 early classical swine lineages. Significantly, we have identified reassortant and recombinant viruses (H3N2, H1N1) not previously reported in Colombia. This suggests a broad genotypic viral diversity, likely resulting from reassortment between classical endemic viruses and new introductions established in Colombia's swine population (e.g. the 2009 H1N1 pandemic). Our study highlights the importance of a One Health approach in disease control, particularly in an ecosystem where humans are a main source of IAV to swine populations, and emphasizes the need for continued surveillance and enhanced biosecurity measures. The co-circulation of multiple subtypes in regions with high swine density facilitates viral exchange, underscoring the importance of monitoring viral evolution to inform vaccine selection and public health policies locally and globally. |
| format | Article |
| id | doaj-art-fcd31d0a114c409fb65c94245fe54a22 |
| institution | OA Journals |
| issn | 2222-1751 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Emerging Microbes and Infections |
| spelling | doaj-art-fcd31d0a114c409fb65c94245fe54a222025-08-20T02:37:32ZengTaylor & Francis GroupEmerging Microbes and Infections2222-17512024-12-0113110.1080/22221751.2024.2368202Genomic diversity and evolutionary dynamics of Influenza A viruses in Colombian swine: implications for one health surveillance and controlKarl Ciuoderis0Jaime Usuga1Laura S. Pérez-Restrepo2Manuel Gonzalez-Ramirez3Leidi Carvajal4Andrés Cardona5Isabel Moreno6Andrés Diaz7Mario Peña8Juan P. Hernández-Ortiz9Jorge E. Osorio10GHI One Health Colombia, Universidad Nacional de Colombia, Medellín, ColombiaGHI One Health Colombia, Universidad Nacional de Colombia, Medellín, ColombiaGHI One Health Colombia, Universidad Nacional de Colombia, Medellín, ColombiaGHI One Health Colombia, Universidad Nacional de Colombia, Medellín, ColombiaGHI One Health Colombia, Universidad Nacional de Colombia, Medellín, ColombiaGHI One Health Colombia, Universidad Nacional de Colombia, Medellín, ColombiaGHI One Health Colombia, Universidad Nacional de Colombia, Medellín, ColombiaPig Improvement Company, Hendersonville, NC, USAPorkColombia Association, Bogotá, ColombiaGHI One Health Colombia, Universidad Nacional de Colombia, Medellín, ColombiaGHI One Health Colombia, Universidad Nacional de Colombia, Medellín, ColombiaInfluenza A viruses (IAV) impose significant respiratory disease burdens in both swine and humans worldwide, with frequent human-to-swine transmission driving viral evolution in pigs and highlighting the risk at the animal-human interface. Therefore, a comprehensive One Health approach (interconnection among human, animal, and environmental health) is needed for IAV prevention, control, and response. Animal influenza genomic surveillance remains limited in many Latin American countries, including Colombia. To address this gap, we genetically characterized 170 swine specimens from Colombia (2011–2017). Whole genome sequencing revealed a predominance of pandemic-like H1N1 lineage, with a minority belonging to H3N2 and H1N2 human seasonal-like lineage and H1N1 early classical swine lineages. Significantly, we have identified reassortant and recombinant viruses (H3N2, H1N1) not previously reported in Colombia. This suggests a broad genotypic viral diversity, likely resulting from reassortment between classical endemic viruses and new introductions established in Colombia's swine population (e.g. the 2009 H1N1 pandemic). Our study highlights the importance of a One Health approach in disease control, particularly in an ecosystem where humans are a main source of IAV to swine populations, and emphasizes the need for continued surveillance and enhanced biosecurity measures. The co-circulation of multiple subtypes in regions with high swine density facilitates viral exchange, underscoring the importance of monitoring viral evolution to inform vaccine selection and public health policies locally and globally.https://www.tandfonline.com/doi/10.1080/22221751.2024.2368202Influenza A virusesswine healthgenetic characterizationColombiareassortmentone health |
| spellingShingle | Karl Ciuoderis Jaime Usuga Laura S. Pérez-Restrepo Manuel Gonzalez-Ramirez Leidi Carvajal Andrés Cardona Isabel Moreno Andrés Diaz Mario Peña Juan P. Hernández-Ortiz Jorge E. Osorio Genomic diversity and evolutionary dynamics of Influenza A viruses in Colombian swine: implications for one health surveillance and control Emerging Microbes and Infections Influenza A viruses swine health genetic characterization Colombia reassortment one health |
| title | Genomic diversity and evolutionary dynamics of Influenza A viruses in Colombian swine: implications for one health surveillance and control |
| title_full | Genomic diversity and evolutionary dynamics of Influenza A viruses in Colombian swine: implications for one health surveillance and control |
| title_fullStr | Genomic diversity and evolutionary dynamics of Influenza A viruses in Colombian swine: implications for one health surveillance and control |
| title_full_unstemmed | Genomic diversity and evolutionary dynamics of Influenza A viruses in Colombian swine: implications for one health surveillance and control |
| title_short | Genomic diversity and evolutionary dynamics of Influenza A viruses in Colombian swine: implications for one health surveillance and control |
| title_sort | genomic diversity and evolutionary dynamics of influenza a viruses in colombian swine implications for one health surveillance and control |
| topic | Influenza A viruses swine health genetic characterization Colombia reassortment one health |
| url | https://www.tandfonline.com/doi/10.1080/22221751.2024.2368202 |
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