Mediators linking gut microbiota and sporadic Creutzfeldt–Jakob disease: a Mendelian randomization study

Mediators linking gut microbiota and sporadic Creutzfeldt–Jakob disease: a Mendelian randomization study

Abstract While gut microbiome associations with sporadic Creutzfeldt–Jakob disease (sCJD) are recognized, causal mechanisms and mediation via cerebrospinal fluid (CSF) metabolites remain unestablished. Using bidirectional Mendelian randomization (MR) with mediation analysis and integrating genome-wi...

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Bibliographic Details
Main Authors: Jie Shao, Tengfei Su, Jinyan Wang, Xiang Yin, Yue Lang, Yuxin Fu, Li Cui
Format: Article
Language:English
Published: SpringerOpen 2025-08-01
Series:AMB Express
Subjects:
Gut microbiome
Sporadic Creutzfeldt–Jakob disease
Mendelian randomization
Online Access:https://doi.org/10.1186/s13568-025-01932-3
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