A Chinese drug-compatibility-based approach to purslane hydrogels for acute eczema therapy
Purslane (Portulaca oleracea L.) with heat-clearing and detoxicating, anti-inflammatory and resolving swelling, relieving itching and astringing function, has remarkable efficacy for acute eczema. However, most of the clinical applications of purslane are freshly prepared decoction, not as easy to a...
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Frontiers Media S.A.
2025-02-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2025.1504120/full |
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| author | Ling Wang Yuzhong Zhang Shenglin Geng Lan Ma Yiran Wang Dongxu Han Guojuan Fan Weifen Zhang Weifen Zhang Weifen Zhang Yanna Lv Jinlong Ma Jinlong Ma Jinlong Ma |
| author_facet | Ling Wang Yuzhong Zhang Shenglin Geng Lan Ma Yiran Wang Dongxu Han Guojuan Fan Weifen Zhang Weifen Zhang Weifen Zhang Yanna Lv Jinlong Ma Jinlong Ma Jinlong Ma |
| author_sort | Ling Wang |
| collection | DOAJ |
| description | Purslane (Portulaca oleracea L.) with heat-clearing and detoxicating, anti-inflammatory and resolving swelling, relieving itching and astringing function, has remarkable efficacy for acute eczema. However, most of the clinical applications of purslane are freshly prepared decoction, not as easy to apply as cream, because the decoction is easy to breed bacteria and easy to oxidize. Here, based on the theory of Chinese medicines compatibility, we made a purslane-tannic acid hydrogel (PL-HATA) by simple methods under mild conditions to solve the drawbacks of easy oxidation and inconvenience of use of Purslane. The antimicrobial activity of PL-HATA hydrogel can exert an excellent antimicrobial effect, reducing the flora on the skin of acute eczema and further relieving the symptoms of acute eczema. At the same time, it creates a normal reactive oxygen species (ROS) microenvironment for acute eczema and promotes recovery from acute eczema. It also improves the symptoms of acute eczema by promoting cell proliferation and migration. Importantly, it resulted in improved skin lesion scores, scratching behavior, eosinophil infiltration, swelling and inflammation levels, immune homeostasis, and histopathological changes in rats with acute eczema. Besides, HATA hydrogel is not only suitable for Purslane’s decocted metabolites but also for Purslane’s freshly squeezed metabolites. This purslane application protocol solved the drawbacks of Purslane’s decoction, improved its storage stability and convenience of use, which is the key issue to further promote its clinical application. |
| format | Article |
| id | doaj-art-fccc8976305341fc9ca1617621cf3ecd |
| institution | Kabale University |
| issn | 1663-9812 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj-art-fccc8976305341fc9ca1617621cf3ecd2025-02-05T07:32:36ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122025-02-011610.3389/fphar.2025.15041201504120A Chinese drug-compatibility-based approach to purslane hydrogels for acute eczema therapyLing Wang0Yuzhong Zhang1Shenglin Geng2Lan Ma3Yiran Wang4Dongxu Han5Guojuan Fan6Weifen Zhang7Weifen Zhang8Weifen Zhang9Yanna Lv10Jinlong Ma11Jinlong Ma12Jinlong Ma13School of Pharmacy, Shandong Second Medical University, Weifang, Shandong, ChinaSchool of Pharmacy, Shandong Second Medical University, Weifang, Shandong, ChinaSchool of Pharmacy, Shandong Second Medical University, Weifang, Shandong, ChinaSchool of Pharmacy, Shandong Second Medical University, Weifang, Shandong, ChinaSchool of Pharmacy, Shandong Second Medical University, Weifang, Shandong, ChinaSchool of Pharmacy, Shandong Second Medical University, Weifang, Shandong, ChinaDermatology, Weifang Hospital of Traditional Chinese Medicine, Shandong Second Medical University, Weifang, Shandong, ChinaSchool of Pharmacy, Shandong Second Medical University, Weifang, Shandong, ChinaCollaborative Innovation Center for Target Drug Delivery System, Shandong Second Medical University, Weifang, Shandong, ChinaShandong Engineering Research Center for Smart Materials and Regenerative Medicine, Shandong Second Medical University, Weifang, Shandong, ChinaSchool of Pharmacy, Shandong Second Medical University, Weifang, Shandong, ChinaSchool of Pharmacy, Shandong Second Medical University, Weifang, Shandong, ChinaCollaborative Innovation Center for Target Drug Delivery System, Shandong Second Medical University, Weifang, Shandong, ChinaShandong Engineering Research Center for Smart Materials and Regenerative Medicine, Shandong Second Medical University, Weifang, Shandong, ChinaPurslane (Portulaca oleracea L.) with heat-clearing and detoxicating, anti-inflammatory and resolving swelling, relieving itching and astringing function, has remarkable efficacy for acute eczema. However, most of the clinical applications of purslane are freshly prepared decoction, not as easy to apply as cream, because the decoction is easy to breed bacteria and easy to oxidize. Here, based on the theory of Chinese medicines compatibility, we made a purslane-tannic acid hydrogel (PL-HATA) by simple methods under mild conditions to solve the drawbacks of easy oxidation and inconvenience of use of Purslane. The antimicrobial activity of PL-HATA hydrogel can exert an excellent antimicrobial effect, reducing the flora on the skin of acute eczema and further relieving the symptoms of acute eczema. At the same time, it creates a normal reactive oxygen species (ROS) microenvironment for acute eczema and promotes recovery from acute eczema. It also improves the symptoms of acute eczema by promoting cell proliferation and migration. Importantly, it resulted in improved skin lesion scores, scratching behavior, eosinophil infiltration, swelling and inflammation levels, immune homeostasis, and histopathological changes in rats with acute eczema. Besides, HATA hydrogel is not only suitable for Purslane’s decocted metabolites but also for Purslane’s freshly squeezed metabolites. This purslane application protocol solved the drawbacks of Purslane’s decoction, improved its storage stability and convenience of use, which is the key issue to further promote its clinical application.https://www.frontiersin.org/articles/10.3389/fphar.2025.1504120/fullpurslaneeczemahydrogelstanninsdrug compatibility |
| spellingShingle | Ling Wang Yuzhong Zhang Shenglin Geng Lan Ma Yiran Wang Dongxu Han Guojuan Fan Weifen Zhang Weifen Zhang Weifen Zhang Yanna Lv Jinlong Ma Jinlong Ma Jinlong Ma A Chinese drug-compatibility-based approach to purslane hydrogels for acute eczema therapy Frontiers in Pharmacology purslane eczema hydrogels tannins drug compatibility |
| title | A Chinese drug-compatibility-based approach to purslane hydrogels for acute eczema therapy |
| title_full | A Chinese drug-compatibility-based approach to purslane hydrogels for acute eczema therapy |
| title_fullStr | A Chinese drug-compatibility-based approach to purslane hydrogels for acute eczema therapy |
| title_full_unstemmed | A Chinese drug-compatibility-based approach to purslane hydrogels for acute eczema therapy |
| title_short | A Chinese drug-compatibility-based approach to purslane hydrogels for acute eczema therapy |
| title_sort | chinese drug compatibility based approach to purslane hydrogels for acute eczema therapy |
| topic | purslane eczema hydrogels tannins drug compatibility |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2025.1504120/full |
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