Management of Iron Overload in Resource Poor Nations: A Systematic Review of Phlebotomy and Natural Chelators
Iron is an essential element and the most abundant trace metal in the body involved in oxygen transport and oxygen sensing, electron transfer, energy metabolism, and DNA synthesis. Excess labile and unchelated iron can catalyze the formation of tissue-damaging radicals and induce oxidative stress. E...
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Journal of Toxicology |
| Online Access: | http://dx.doi.org/10.1155/2020/4084538 |
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| author | Orish Ebere Orisakwe Cecilia Nwadiuto Amadi Chiara Frazzoli |
| author_facet | Orish Ebere Orisakwe Cecilia Nwadiuto Amadi Chiara Frazzoli |
| author_sort | Orish Ebere Orisakwe |
| collection | DOAJ |
| description | Iron is an essential element and the most abundant trace metal in the body involved in oxygen transport and oxygen sensing, electron transfer, energy metabolism, and DNA synthesis. Excess labile and unchelated iron can catalyze the formation of tissue-damaging radicals and induce oxidative stress. English abstracts were identified in PubMed and Google Scholar using multiple and various search terms based on defined inclusion and exclusion criteria. Full-length articles were selected for systematic review, and secondary and tertiary references were developed. Although bloodletting or phlebotomy remains the gold standard in the management of iron overload, this systematic review is an updated account of the pitfalls of phlebotomy and classical synthetic chelators with scientific justification for the use of natural iron chelators of dietary origin in resource-poor nations. |
| format | Article |
| id | doaj-art-fcbd3ec6ec654c25baba34ef092a95ad |
| institution | Kabale University |
| issn | 1687-8191 1687-8205 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Toxicology |
| spelling | doaj-art-fcbd3ec6ec654c25baba34ef092a95ad2025-02-03T01:04:10ZengWileyJournal of Toxicology1687-81911687-82052020-01-01202010.1155/2020/40845384084538Management of Iron Overload in Resource Poor Nations: A Systematic Review of Phlebotomy and Natural ChelatorsOrish Ebere Orisakwe0Cecilia Nwadiuto Amadi1Chiara Frazzoli2Department of Experimental Pharmacology & Toxicology, Faculty of Pharmacy, University of Port Harcourt Rivers State, NigeriaDepartment of Experimental Pharmacology & Toxicology, Faculty of Pharmacy, University of Port Harcourt Rivers State, NigeriaDepartment for Cardiovascular, Dysmetabolic and Aging Diseases, Istituto Superiore di Sanità, Rome, ItalyIron is an essential element and the most abundant trace metal in the body involved in oxygen transport and oxygen sensing, electron transfer, energy metabolism, and DNA synthesis. Excess labile and unchelated iron can catalyze the formation of tissue-damaging radicals and induce oxidative stress. English abstracts were identified in PubMed and Google Scholar using multiple and various search terms based on defined inclusion and exclusion criteria. Full-length articles were selected for systematic review, and secondary and tertiary references were developed. Although bloodletting or phlebotomy remains the gold standard in the management of iron overload, this systematic review is an updated account of the pitfalls of phlebotomy and classical synthetic chelators with scientific justification for the use of natural iron chelators of dietary origin in resource-poor nations.http://dx.doi.org/10.1155/2020/4084538 |
| spellingShingle | Orish Ebere Orisakwe Cecilia Nwadiuto Amadi Chiara Frazzoli Management of Iron Overload in Resource Poor Nations: A Systematic Review of Phlebotomy and Natural Chelators Journal of Toxicology |
| title | Management of Iron Overload in Resource Poor Nations: A Systematic Review of Phlebotomy and Natural Chelators |
| title_full | Management of Iron Overload in Resource Poor Nations: A Systematic Review of Phlebotomy and Natural Chelators |
| title_fullStr | Management of Iron Overload in Resource Poor Nations: A Systematic Review of Phlebotomy and Natural Chelators |
| title_full_unstemmed | Management of Iron Overload in Resource Poor Nations: A Systematic Review of Phlebotomy and Natural Chelators |
| title_short | Management of Iron Overload in Resource Poor Nations: A Systematic Review of Phlebotomy and Natural Chelators |
| title_sort | management of iron overload in resource poor nations a systematic review of phlebotomy and natural chelators |
| url | http://dx.doi.org/10.1155/2020/4084538 |
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