Long-Term Biostability of Pet Vascular Prostheses
PET Vascular prostheses are susceptible to physical modification and chemical degradation leading sometimes to global deterioration and rupture of the product. To understand the mechanisms of degradation, we studied 6 vascular prostheses that were explanted due to medical complications. We character...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | International Journal of Polymer Science |
| Online Access: | http://dx.doi.org/10.1155/2012/646578 |
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| _version_ | 1832568331136139264 |
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| author | Florence Dieval Foued Khoffi Riaz Mir Walid Chaouch Didier Le Nouen Nabil Chakfe Bernard Durand |
| author_facet | Florence Dieval Foued Khoffi Riaz Mir Walid Chaouch Didier Le Nouen Nabil Chakfe Bernard Durand |
| author_sort | Florence Dieval |
| collection | DOAJ |
| description | PET Vascular prostheses are susceptible to physical modification and chemical degradation leading sometimes to global deterioration and rupture of the product. To understand the mechanisms of degradation, we studied 6 vascular prostheses that were explanted due to medical complications. We characterized their level of degradation by comparing them with a virgin prosthesis and carried out physicochemical and mechanical analyses. Results showed an important reduction of the fabric’s mechanical properties in specific areas. Moreover, PET taken from these areas exhibited structural anomalies and was highly degraded even in virgin prostheses. These results suggest that vascular prostheses have weak areas prior to implantation and that these areas are much more prone to in vivo degradation by human metabolism. Manufacturing process could be responsible for these weaknesses as well as designing of the compound. Therefore, we suggest that a more controlled manufacturing process could lead to a vascular prosthesis with enhanced lifespan. |
| format | Article |
| id | doaj-art-fcb90a15ba8c44b4abd3b7652da082a4 |
| institution | Kabale University |
| issn | 1687-9422 1687-9430 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Polymer Science |
| spelling | doaj-art-fcb90a15ba8c44b4abd3b7652da082a42025-02-03T00:59:17ZengWileyInternational Journal of Polymer Science1687-94221687-94302012-01-01201210.1155/2012/646578646578Long-Term Biostability of Pet Vascular ProsthesesFlorence Dieval0Foued Khoffi1Riaz Mir2Walid Chaouch3Didier Le Nouen4Nabil Chakfe5Bernard Durand6Laboratoire de Physique et Mécanique Textiles, ENSISA, 11 rue des Frères Lumières, 68093 Mulhouse Cedex, FranceLaboratoire de Physique et Mécanique Textiles, ENSISA, 11 rue des Frères Lumières, 68093 Mulhouse Cedex, FranceLaboratoire de Physique et Mécanique Textiles, ENSISA, 11 rue des Frères Lumières, 68093 Mulhouse Cedex, FranceTextile Research Unit, High Technology Institute, Hadj Ali Soua, Ksar-Hellal 5070, TunisiaLaboratoire de Chimie Organique et Bio-organique, École Nationale Supérieure de Chimie de Mulhouse, Université de Haute Alsace, 68093 Mulhouse, FranceDepartment of Vascular Surgery, Les Hôpitaux Universitaires de Strasbourg, University of Strasbourg, 67000 Strasbourg, FranceLaboratoire de Physique et Mécanique Textiles, ENSISA, 11 rue des Frères Lumières, 68093 Mulhouse Cedex, FrancePET Vascular prostheses are susceptible to physical modification and chemical degradation leading sometimes to global deterioration and rupture of the product. To understand the mechanisms of degradation, we studied 6 vascular prostheses that were explanted due to medical complications. We characterized their level of degradation by comparing them with a virgin prosthesis and carried out physicochemical and mechanical analyses. Results showed an important reduction of the fabric’s mechanical properties in specific areas. Moreover, PET taken from these areas exhibited structural anomalies and was highly degraded even in virgin prostheses. These results suggest that vascular prostheses have weak areas prior to implantation and that these areas are much more prone to in vivo degradation by human metabolism. Manufacturing process could be responsible for these weaknesses as well as designing of the compound. Therefore, we suggest that a more controlled manufacturing process could lead to a vascular prosthesis with enhanced lifespan.http://dx.doi.org/10.1155/2012/646578 |
| spellingShingle | Florence Dieval Foued Khoffi Riaz Mir Walid Chaouch Didier Le Nouen Nabil Chakfe Bernard Durand Long-Term Biostability of Pet Vascular Prostheses International Journal of Polymer Science |
| title | Long-Term Biostability of Pet Vascular Prostheses |
| title_full | Long-Term Biostability of Pet Vascular Prostheses |
| title_fullStr | Long-Term Biostability of Pet Vascular Prostheses |
| title_full_unstemmed | Long-Term Biostability of Pet Vascular Prostheses |
| title_short | Long-Term Biostability of Pet Vascular Prostheses |
| title_sort | long term biostability of pet vascular prostheses |
| url | http://dx.doi.org/10.1155/2012/646578 |
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