Deciphering the bone marrow microenvironment’s role in multiple myeloma immunotherapy resistance

Deciphering the bone marrow microenvironment’s role in multiple myeloma immunotherapy resistance

Multiple Myeloma (MM) is a malignant monoclonal gammopathy characterized by the proliferation of plasma cells (PC) in the bone marrow (BM). The tight cross-talk between the BM microenvironment and PC is the hallmark of MM. The BM microenvironment comprises a cellular compartment, consisting of hemat...

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Bibliographic Details
Main Authors: Nicolas Thomas Iannozzi, Nicola Giuliani, Paola Storti
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Immunology
Subjects:
multiple myeloma
resistance
mesenchymal cells
car-t
bi-specific antibodies
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1613265/full
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