Sleep-driven prefrontal cortex coordinates temporal action and multimodal integration
Abstract Cognitive processes such as action planning and decision-making require the integration of multiple sensory modalities in response to temporal cues, yet the underlying mechanism is not fully understood. Sleep has a crucial role for memory consolidation and promoting cognitive flexibility. O...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2025-01-01
|
| Series: | Molecular Brain |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13041-025-01175-0 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832585328905420800 |
|---|---|
| author | Ahmed Z. Ibrahim Kareem Abdou Masanori Nomoto Kaori Yamada-Nomoto Reiko Okubo-Suzuki Kaoru Inokuchi |
| author_facet | Ahmed Z. Ibrahim Kareem Abdou Masanori Nomoto Kaori Yamada-Nomoto Reiko Okubo-Suzuki Kaoru Inokuchi |
| author_sort | Ahmed Z. Ibrahim |
| collection | DOAJ |
| description | Abstract Cognitive processes such as action planning and decision-making require the integration of multiple sensory modalities in response to temporal cues, yet the underlying mechanism is not fully understood. Sleep has a crucial role for memory consolidation and promoting cognitive flexibility. Our aim is to identify the role of sleep in integrating different modalities to enhance cognitive flexibility and temporal task execution while identifying the specific brain regions that mediate this process. We have designed “Auditory-Gated Patience-to-Action” Task in which mice should process different auditory signals before action execution as well as analyzing the visual inputs for feedback of their action. Mice could learn the task rule and apply it only after sleeping period and could keep the performance constant across sessions. c-fos positive cells showed the involvement of prelimbic cortex (PrL) during task execution. Chemo-genetic inhibition verified that PrL is required for proper signal response and action timing. These findings emphasize that sleep and cortical activity are keys for cognitive flexibility in adapting to different modalities. |
| format | Article |
| id | doaj-art-fcab99daaef24d1a8cf4a00ebc6b7fbd |
| institution | Kabale University |
| issn | 1756-6606 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Molecular Brain |
| spelling | doaj-art-fcab99daaef24d1a8cf4a00ebc6b7fbd2025-01-26T12:58:05ZengBMCMolecular Brain1756-66062025-01-011811710.1186/s13041-025-01175-0Sleep-driven prefrontal cortex coordinates temporal action and multimodal integrationAhmed Z. Ibrahim0Kareem Abdou1Masanori Nomoto2Kaori Yamada-Nomoto3Reiko Okubo-Suzuki4Kaoru Inokuchi5Research Centre for Idling Brain Science, University of ToyamaDepartment of Biochemistry, Faculty of Pharmacy, Cairo UniversityResearch Centre for Idling Brain Science, University of ToyamaResearch Centre for Idling Brain Science, University of ToyamaResearch Centre for Idling Brain Science, University of ToyamaResearch Centre for Idling Brain Science, University of ToyamaAbstract Cognitive processes such as action planning and decision-making require the integration of multiple sensory modalities in response to temporal cues, yet the underlying mechanism is not fully understood. Sleep has a crucial role for memory consolidation and promoting cognitive flexibility. Our aim is to identify the role of sleep in integrating different modalities to enhance cognitive flexibility and temporal task execution while identifying the specific brain regions that mediate this process. We have designed “Auditory-Gated Patience-to-Action” Task in which mice should process different auditory signals before action execution as well as analyzing the visual inputs for feedback of their action. Mice could learn the task rule and apply it only after sleeping period and could keep the performance constant across sessions. c-fos positive cells showed the involvement of prelimbic cortex (PrL) during task execution. Chemo-genetic inhibition verified that PrL is required for proper signal response and action timing. These findings emphasize that sleep and cortical activity are keys for cognitive flexibility in adapting to different modalities.https://doi.org/10.1186/s13041-025-01175-0Cognitive flexibilityIdlingSleepPrefrontal cortexMulti-modal integrationTemporal actions |
| spellingShingle | Ahmed Z. Ibrahim Kareem Abdou Masanori Nomoto Kaori Yamada-Nomoto Reiko Okubo-Suzuki Kaoru Inokuchi Sleep-driven prefrontal cortex coordinates temporal action and multimodal integration Molecular Brain Cognitive flexibility Idling Sleep Prefrontal cortex Multi-modal integration Temporal actions |
| title | Sleep-driven prefrontal cortex coordinates temporal action and multimodal integration |
| title_full | Sleep-driven prefrontal cortex coordinates temporal action and multimodal integration |
| title_fullStr | Sleep-driven prefrontal cortex coordinates temporal action and multimodal integration |
| title_full_unstemmed | Sleep-driven prefrontal cortex coordinates temporal action and multimodal integration |
| title_short | Sleep-driven prefrontal cortex coordinates temporal action and multimodal integration |
| title_sort | sleep driven prefrontal cortex coordinates temporal action and multimodal integration |
| topic | Cognitive flexibility Idling Sleep Prefrontal cortex Multi-modal integration Temporal actions |
| url | https://doi.org/10.1186/s13041-025-01175-0 |
| work_keys_str_mv | AT ahmedzibrahim sleepdrivenprefrontalcortexcoordinatestemporalactionandmultimodalintegration AT kareemabdou sleepdrivenprefrontalcortexcoordinatestemporalactionandmultimodalintegration AT masanorinomoto sleepdrivenprefrontalcortexcoordinatestemporalactionandmultimodalintegration AT kaoriyamadanomoto sleepdrivenprefrontalcortexcoordinatestemporalactionandmultimodalintegration AT reikookubosuzuki sleepdrivenprefrontalcortexcoordinatestemporalactionandmultimodalintegration AT kaoruinokuchi sleepdrivenprefrontalcortexcoordinatestemporalactionandmultimodalintegration |