Noninvasive Evaluation of Liver Fibrosis in a Sample of Putative Inactive HBV Carriers in Rome, Italy
Background. Noninvasive methods are useful for investigating patients with chronic HBV infection. The severity of liver disease in inactive HBsAg carriers can be noninvasively assessed by transient elastography (TE) alone or in association with biochemical markers of fibrosis. Objectives. The study...
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Wiley
2021-01-01
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| Series: | Canadian Journal of Infectious Diseases and Medical Microbiology |
| Online Access: | http://dx.doi.org/10.1155/2021/3068690 |
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| author | Marco Delle Monache Alessio Petrelli Alessandra Rossi Roberto Cecere Concetta Mirisola Gianfranco Costanzo Chiara Francia Federica Cerini Andrea Cavani Lorenzo Nosotti |
| author_facet | Marco Delle Monache Alessio Petrelli Alessandra Rossi Roberto Cecere Concetta Mirisola Gianfranco Costanzo Chiara Francia Federica Cerini Andrea Cavani Lorenzo Nosotti |
| author_sort | Marco Delle Monache |
| collection | DOAJ |
| description | Background. Noninvasive methods are useful for investigating patients with chronic HBV infection. The severity of liver disease in inactive HBsAg carriers can be noninvasively assessed by transient elastography (TE) alone or in association with biochemical markers of fibrosis. Objectives. The study evaluates the effectiveness of the TE compared to common fibrosis scores (FSs), APRI, Forns Index, and FIB4, for identifying significant fibrosis in Italian and foreigner HBsAg carriers. To investigate the risk of progression of the liver disease, liver stiffness (LS) and HBV-DNA were monitored over time. Methods. Viral load, biochemical parameters, and LS have been retrospectively evaluated in 125 putative inactive HBV carriers, who visited two outpatient departments (Colleferro Hospital and INMP) from 01/03/2014 to 31/12/2019. Differences in clinical, biochemical, and demographic variables between Italians and foreigners were analyzed. 66 of 125 patients were followed up for 24 months by monitoring liver stiffness and HBV-DNA. Results. Mean overall LS was 5.55 ± 1.92 kPa; 18 (14.4%) patients had a LS ≥7.5 kPa. Mean of APRI, Forns, and FIB4 was 0.29 ± 0.11, 4.15 ± 1.63, and 1.16 ± 0.59, respectively. FS did not differ between the patients with LS <7.5 kPa and those with LS ≥7.5 kPa. Italians displayed a significant lower ALT (0.53 ± 0.18 vs. 0.67 ± 0.33, p<0.05) and AST (0.59 ± 0.16 vs. 0.70 ± 0.21, p<0.01) value than foreigners. No differences in LS and HBV-DNA levels were observed. In 66 patients followed up for 24 months, HBV-DNA increased by ≥2000 UI/ml after 12 months in 15 individuals and remained ≥2000 UI/ml after 24 months in 10/15 individuals. 7/10 patients showed LS ≥ 7.5 kPa after 24 months, and 4 of them underwent antiviral therapy for HBV. Patients with HBV-DNA <2000 IU/ml had a significantly lower LS than those with HBV-DNA ≥2000 IU/ml (5.30 ± 1.43 vs. 7.69 ± 1.07, p<0.0001). Conclusions. Analysis shows lower effectiveness of FS vs. TE in the assessment of putative inactive HBV carriers. Furthermore, using FibroScan® and HBV-DNA can identify “false” inactive carriers. |
| format | Article |
| id | doaj-art-fca654f3a670414cab52e28d729eb2ec |
| institution | Kabale University |
| issn | 1712-9532 1918-1493 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
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| series | Canadian Journal of Infectious Diseases and Medical Microbiology |
| spelling | doaj-art-fca654f3a670414cab52e28d729eb2ec2025-02-03T01:24:51ZengWileyCanadian Journal of Infectious Diseases and Medical Microbiology1712-95321918-14932021-01-01202110.1155/2021/30686903068690Noninvasive Evaluation of Liver Fibrosis in a Sample of Putative Inactive HBV Carriers in Rome, ItalyMarco Delle Monache0Alessio Petrelli1Alessandra Rossi2Roberto Cecere3Concetta Mirisola4Gianfranco Costanzo5Chiara Francia6Federica Cerini7Andrea Cavani8Lorenzo Nosotti9Liver and Infectious Diseases Unit, L. Parodi Delfino Hospital, ASL RM5 P.le A. Moro 1, Colleferro, Rome 00034, ItalyNational Institute for Health, Migration and Poverty (NIHMP), Via di San Gallicano 25/a, Rome 00153, ItalyNational Institute for Health, Migration and Poverty (NIHMP), Via di San Gallicano 25/a, Rome 00153, ItalyLiver and Infectious Diseases Unit, L. Parodi Delfino Hospital, ASL RM5 P.le A. Moro 1, Colleferro, Rome 00034, ItalyNational Institute for Health, Migration and Poverty (NIHMP), Via di San Gallicano 25/a, Rome 00153, ItalyNational Institute for Health, Migration and Poverty (NIHMP), Via di San Gallicano 25/a, Rome 00153, ItalyLiver and Infectious Diseases Unit, L. Parodi Delfino Hospital, ASL RM5 P.le A. Moro 1, Colleferro, Rome 00034, ItalyLiver and Infectious Diseases Unit, L. Parodi Delfino Hospital, ASL RM5 P.le A. Moro 1, Colleferro, Rome 00034, ItalyNational Institute for Health, Migration and Poverty (NIHMP), Via di San Gallicano 25/a, Rome 00153, ItalyNational Institute for Health, Migration and Poverty (NIHMP), Via di San Gallicano 25/a, Rome 00153, ItalyBackground. Noninvasive methods are useful for investigating patients with chronic HBV infection. The severity of liver disease in inactive HBsAg carriers can be noninvasively assessed by transient elastography (TE) alone or in association with biochemical markers of fibrosis. Objectives. The study evaluates the effectiveness of the TE compared to common fibrosis scores (FSs), APRI, Forns Index, and FIB4, for identifying significant fibrosis in Italian and foreigner HBsAg carriers. To investigate the risk of progression of the liver disease, liver stiffness (LS) and HBV-DNA were monitored over time. Methods. Viral load, biochemical parameters, and LS have been retrospectively evaluated in 125 putative inactive HBV carriers, who visited two outpatient departments (Colleferro Hospital and INMP) from 01/03/2014 to 31/12/2019. Differences in clinical, biochemical, and demographic variables between Italians and foreigners were analyzed. 66 of 125 patients were followed up for 24 months by monitoring liver stiffness and HBV-DNA. Results. Mean overall LS was 5.55 ± 1.92 kPa; 18 (14.4%) patients had a LS ≥7.5 kPa. Mean of APRI, Forns, and FIB4 was 0.29 ± 0.11, 4.15 ± 1.63, and 1.16 ± 0.59, respectively. FS did not differ between the patients with LS <7.5 kPa and those with LS ≥7.5 kPa. Italians displayed a significant lower ALT (0.53 ± 0.18 vs. 0.67 ± 0.33, p<0.05) and AST (0.59 ± 0.16 vs. 0.70 ± 0.21, p<0.01) value than foreigners. No differences in LS and HBV-DNA levels were observed. In 66 patients followed up for 24 months, HBV-DNA increased by ≥2000 UI/ml after 12 months in 15 individuals and remained ≥2000 UI/ml after 24 months in 10/15 individuals. 7/10 patients showed LS ≥ 7.5 kPa after 24 months, and 4 of them underwent antiviral therapy for HBV. Patients with HBV-DNA <2000 IU/ml had a significantly lower LS than those with HBV-DNA ≥2000 IU/ml (5.30 ± 1.43 vs. 7.69 ± 1.07, p<0.0001). Conclusions. Analysis shows lower effectiveness of FS vs. TE in the assessment of putative inactive HBV carriers. Furthermore, using FibroScan® and HBV-DNA can identify “false” inactive carriers.http://dx.doi.org/10.1155/2021/3068690 |
| spellingShingle | Marco Delle Monache Alessio Petrelli Alessandra Rossi Roberto Cecere Concetta Mirisola Gianfranco Costanzo Chiara Francia Federica Cerini Andrea Cavani Lorenzo Nosotti Noninvasive Evaluation of Liver Fibrosis in a Sample of Putative Inactive HBV Carriers in Rome, Italy Canadian Journal of Infectious Diseases and Medical Microbiology |
| title | Noninvasive Evaluation of Liver Fibrosis in a Sample of Putative Inactive HBV Carriers in Rome, Italy |
| title_full | Noninvasive Evaluation of Liver Fibrosis in a Sample of Putative Inactive HBV Carriers in Rome, Italy |
| title_fullStr | Noninvasive Evaluation of Liver Fibrosis in a Sample of Putative Inactive HBV Carriers in Rome, Italy |
| title_full_unstemmed | Noninvasive Evaluation of Liver Fibrosis in a Sample of Putative Inactive HBV Carriers in Rome, Italy |
| title_short | Noninvasive Evaluation of Liver Fibrosis in a Sample of Putative Inactive HBV Carriers in Rome, Italy |
| title_sort | noninvasive evaluation of liver fibrosis in a sample of putative inactive hbv carriers in rome italy |
| url | http://dx.doi.org/10.1155/2021/3068690 |
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