Short-Term Efficacy of Exclusive Enteral Nutrition in Pediatric Crohn’s Disease: Practice in China
Aims. The objective of this study was to compare the efficacy of exclusive enteral nutrition (EEN) and corticosteroids in inducing remission in pediatric Crohn’s disease (CD) and the effects of the treatment on growth improvements. Methods. Data was retrospectively collected for children and adolesc...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Gastroenterology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2015/428354 |
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| author | Youyou Luo Jindan Yu Hong Zhao Jingan Lou Feibo Chen Kerong Peng Jie Chen |
| author_facet | Youyou Luo Jindan Yu Hong Zhao Jingan Lou Feibo Chen Kerong Peng Jie Chen |
| author_sort | Youyou Luo |
| collection | DOAJ |
| description | Aims. The objective of this study was to compare the efficacy of exclusive enteral nutrition (EEN) and corticosteroids in inducing remission in pediatric Crohn’s disease (CD) and the effects of the treatment on growth improvements. Methods. Data was retrospectively collected for children and adolescents newly diagnosed with CD in a referral center. Patients who were followed up for more than 2 months with mild to moderate disease were included. Basic demographics, history, physical examination, the pediatric Crohn disease activity index (PCDAI), laboratory findings, endoscopic findings, and adverse effects were recorded. Remission was defined as PCDAI < 10 points. Results. Ten subjects received EEN and 18 patients received corticosteroids. The median follow-up in EEN group and steroid group was 9.2 weeks and 9.6 weeks, respectively. The remission rate in EEN group was significantly higher than that in steroid group (90.0% versus 50.0%, resp., P<0.05). Growth improvement, which was evaluated by changes in height for age z-score, was more apparent in EEN group than that in steroids group P<0.05. No adverse effects were observed in EEN group. Conclusions. In children with mild to moderate CD, EEN is more effective than corticosteroids in improving disease severity and growth deficiency, as well as providing less side effects. |
| format | Article |
| id | doaj-art-fc912d3855d542df8248ee0a11c9610a |
| institution | Kabale University |
| issn | 1687-6121 1687-630X |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Gastroenterology Research and Practice |
| spelling | doaj-art-fc912d3855d542df8248ee0a11c9610a2025-02-03T07:25:19ZengWileyGastroenterology Research and Practice1687-61211687-630X2015-01-01201510.1155/2015/428354428354Short-Term Efficacy of Exclusive Enteral Nutrition in Pediatric Crohn’s Disease: Practice in ChinaYouyou Luo0Jindan Yu1Hong Zhao2Jingan Lou3Feibo Chen4Kerong Peng5Jie Chen6Gastroenterology Department, The Children’s Hospital, School of Medicine, Zhejiang University, Hangzhou 310051, ChinaGastroenterology Department, The Children’s Hospital, School of Medicine, Zhejiang University, Hangzhou 310051, ChinaGastroenterology Department, The Children’s Hospital, School of Medicine, Zhejiang University, Hangzhou 310051, ChinaGastroenterology Department, The Children’s Hospital, School of Medicine, Zhejiang University, Hangzhou 310051, ChinaGastroenterology Department, The Children’s Hospital, School of Medicine, Zhejiang University, Hangzhou 310051, ChinaGastroenterology Department, The Children’s Hospital, School of Medicine, Zhejiang University, Hangzhou 310051, ChinaGastroenterology Department, The Children’s Hospital, School of Medicine, Zhejiang University, Hangzhou 310051, ChinaAims. The objective of this study was to compare the efficacy of exclusive enteral nutrition (EEN) and corticosteroids in inducing remission in pediatric Crohn’s disease (CD) and the effects of the treatment on growth improvements. Methods. Data was retrospectively collected for children and adolescents newly diagnosed with CD in a referral center. Patients who were followed up for more than 2 months with mild to moderate disease were included. Basic demographics, history, physical examination, the pediatric Crohn disease activity index (PCDAI), laboratory findings, endoscopic findings, and adverse effects were recorded. Remission was defined as PCDAI < 10 points. Results. Ten subjects received EEN and 18 patients received corticosteroids. The median follow-up in EEN group and steroid group was 9.2 weeks and 9.6 weeks, respectively. The remission rate in EEN group was significantly higher than that in steroid group (90.0% versus 50.0%, resp., P<0.05). Growth improvement, which was evaluated by changes in height for age z-score, was more apparent in EEN group than that in steroids group P<0.05. No adverse effects were observed in EEN group. Conclusions. In children with mild to moderate CD, EEN is more effective than corticosteroids in improving disease severity and growth deficiency, as well as providing less side effects.http://dx.doi.org/10.1155/2015/428354 |
| spellingShingle | Youyou Luo Jindan Yu Hong Zhao Jingan Lou Feibo Chen Kerong Peng Jie Chen Short-Term Efficacy of Exclusive Enteral Nutrition in Pediatric Crohn’s Disease: Practice in China Gastroenterology Research and Practice |
| title | Short-Term Efficacy of Exclusive Enteral Nutrition in Pediatric Crohn’s Disease: Practice in China |
| title_full | Short-Term Efficacy of Exclusive Enteral Nutrition in Pediatric Crohn’s Disease: Practice in China |
| title_fullStr | Short-Term Efficacy of Exclusive Enteral Nutrition in Pediatric Crohn’s Disease: Practice in China |
| title_full_unstemmed | Short-Term Efficacy of Exclusive Enteral Nutrition in Pediatric Crohn’s Disease: Practice in China |
| title_short | Short-Term Efficacy of Exclusive Enteral Nutrition in Pediatric Crohn’s Disease: Practice in China |
| title_sort | short term efficacy of exclusive enteral nutrition in pediatric crohn s disease practice in china |
| url | http://dx.doi.org/10.1155/2015/428354 |
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