Suppression of monocyte and neutrophil function by recombinant IL-2
Little IS known about the influence of IL-2 on phagocytes. We now describe the effects of human recombinant IL-2 on human neutrophil and monocyte functions related to mobility, phagocytosis, glucose uptake, respiration and degranulation. Neutrophil adherence and hexose monophosphate shunt activities...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wiley
1993-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/S0962935193000080 |
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| _version_ | 1832550249273491456 |
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| author | Susan E. Smith Gayle D. Warren Yee-Hing Thong Joe G. McCormack |
| author_facet | Susan E. Smith Gayle D. Warren Yee-Hing Thong Joe G. McCormack |
| author_sort | Susan E. Smith |
| collection | DOAJ |
| description | Little IS known about the influence of IL-2 on phagocytes. We now describe the effects of human recombinant IL-2 on human neutrophil and monocyte functions related to mobility, phagocytosis, glucose uptake, respiration and degranulation. Neutrophil adherence and hexose monophosphate shunt activities were both suppressed after incubation with IL-2. IL-2 had no effect on neutrophil migration, phagocytosis, deoxyglucose uptake or degranulation, ionocytes demonstrated a greater sensitivity to IL-2 with suppression of monocyte adherence, random and stimulated migration, glucose uptake and hexose monophosphate shunt activity, even after addition of phorbol myristate acetate. Monocyte phagocytosis and degranulation were not affected. All of the effects observed were dose-dependent within a biologically active range for IL-2. These studies suggest that IL-2 may have an important down-regulatory role across a broad range of monocyte functions including movement, deoxyglucose uptake and respiration. However, its role in regulation of neutrophil function is limited to adherence and respiration. IL-2 may be a more versatile cytokine than has previously been appreciated. |
| format | Article |
| id | doaj-art-fc700e583b634788a6ae6ab42c1bea70 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 1993-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-fc700e583b634788a6ae6ab42c1bea702025-02-03T06:07:27ZengWileyMediators of Inflammation0962-93511466-18611993-01-0121596510.1155/S0962935193000080Suppression of monocyte and neutrophil function by recombinant IL-2Susan E. Smith0Gayle D. Warren1Yee-Hing Thong2Joe G. McCormack3Department of Child Health, and Immunobiology Laboratory, University of Queensland, Mater Misericordiae Hospitals, South Brisbane, Queensland 4101, AustraliaDepartment of Child Health, and Immunobiology Laboratory, University of Queensland, Mater Misericordiae Hospitals, South Brisbane, Queensland 4101, AustraliaDepartment of Child Health, and Immunobiology Laboratory, University of Queensland, Mater Misericordiae Hospitals, South Brisbane, Queensland 4101, AustraliaDepartment of Medicine, Immunobiology Laboratory, University of Queensland, Mater Misericordiae Hospitals, South Brisbane, Queensland 4101, AustraliaLittle IS known about the influence of IL-2 on phagocytes. We now describe the effects of human recombinant IL-2 on human neutrophil and monocyte functions related to mobility, phagocytosis, glucose uptake, respiration and degranulation. Neutrophil adherence and hexose monophosphate shunt activities were both suppressed after incubation with IL-2. IL-2 had no effect on neutrophil migration, phagocytosis, deoxyglucose uptake or degranulation, ionocytes demonstrated a greater sensitivity to IL-2 with suppression of monocyte adherence, random and stimulated migration, glucose uptake and hexose monophosphate shunt activity, even after addition of phorbol myristate acetate. Monocyte phagocytosis and degranulation were not affected. All of the effects observed were dose-dependent within a biologically active range for IL-2. These studies suggest that IL-2 may have an important down-regulatory role across a broad range of monocyte functions including movement, deoxyglucose uptake and respiration. However, its role in regulation of neutrophil function is limited to adherence and respiration. IL-2 may be a more versatile cytokine than has previously been appreciated.http://dx.doi.org/10.1155/S0962935193000080 |
| spellingShingle | Susan E. Smith Gayle D. Warren Yee-Hing Thong Joe G. McCormack Suppression of monocyte and neutrophil function by recombinant IL-2 Mediators of Inflammation |
| title | Suppression of monocyte and neutrophil function by recombinant IL-2 |
| title_full | Suppression of monocyte and neutrophil function by recombinant IL-2 |
| title_fullStr | Suppression of monocyte and neutrophil function by recombinant IL-2 |
| title_full_unstemmed | Suppression of monocyte and neutrophil function by recombinant IL-2 |
| title_short | Suppression of monocyte and neutrophil function by recombinant IL-2 |
| title_sort | suppression of monocyte and neutrophil function by recombinant il 2 |
| url | http://dx.doi.org/10.1155/S0962935193000080 |
| work_keys_str_mv | AT susanesmith suppressionofmonocyteandneutrophilfunctionbyrecombinantil2 AT gayledwarren suppressionofmonocyteandneutrophilfunctionbyrecombinantil2 AT yeehingthong suppressionofmonocyteandneutrophilfunctionbyrecombinantil2 AT joegmccormack suppressionofmonocyteandneutrophilfunctionbyrecombinantil2 |