In-vitro activation of complement system by lactic acidosis in newborn and adults
Introduction: Complement activation occurs secondary to a variety of external stimuli. Lactic acidosis has been previously shown to activate the complement factors C3a and C5a. In the present investigation we examined the differential effect of lactic acidosis on anaphylatoxin levels in cord and adu...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2001-01-01
|
| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1080/09629350123788 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832549972448378880 |
|---|---|
| author | Friederike Hecke Thomas Hoehn Evelyn Strauss Michael Obladen Josef Sonntag |
| author_facet | Friederike Hecke Thomas Hoehn Evelyn Strauss Michael Obladen Josef Sonntag |
| author_sort | Friederike Hecke |
| collection | DOAJ |
| description | Introduction: Complement activation occurs secondary to a variety of external stimuli. Lactic acidosis has been previously shown to activate the complement factors C3a and C5a. In the present investigation we examined the differential effect of lactic acidosis on anaphylatoxin levels in cord and adult blood. Furthermore we aimed to determine if the entire complement cascade could be activated by lactic acidosis. |
| format | Article |
| id | doaj-art-fc6e76b37f06414db18d6fa830d44914 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2001-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-fc6e76b37f06414db18d6fa830d449142025-02-03T06:08:05ZengWileyMediators of Inflammation0962-93511466-18612001-01-01101273110.1080/09629350123788In-vitro activation of complement system by lactic acidosis in newborn and adultsFriederike Hecke0Thomas Hoehn1Evelyn Strauss2Michael Obladen3Josef Sonntag4Department of Neonatology, Charité Virchow Hospital, Humboldt University, Berlin 13353, GermanyDepartment of Neonatology, Charité Virchow Hospital, Humboldt University, Berlin 13353, GermanyDepartment of Neonatology, Charité Virchow Hospital, Humboldt University, Berlin 13353, GermanyDepartment of Neonatology, Charité Virchow Hospital, Humboldt University, Berlin 13353, GermanyDepartment of Neonatology, Charité Virchow Hospital, Humboldt University, Berlin 13353, GermanyIntroduction: Complement activation occurs secondary to a variety of external stimuli. Lactic acidosis has been previously shown to activate the complement factors C3a and C5a. In the present investigation we examined the differential effect of lactic acidosis on anaphylatoxin levels in cord and adult blood. Furthermore we aimed to determine if the entire complement cascade could be activated by lactic acidosis.http://dx.doi.org/10.1080/09629350123788 |
| spellingShingle | Friederike Hecke Thomas Hoehn Evelyn Strauss Michael Obladen Josef Sonntag In-vitro activation of complement system by lactic acidosis in newborn and adults Mediators of Inflammation |
| title | In-vitro activation of complement system by lactic acidosis in newborn and adults |
| title_full | In-vitro activation of complement system by lactic acidosis in newborn and adults |
| title_fullStr | In-vitro activation of complement system by lactic acidosis in newborn and adults |
| title_full_unstemmed | In-vitro activation of complement system by lactic acidosis in newborn and adults |
| title_short | In-vitro activation of complement system by lactic acidosis in newborn and adults |
| title_sort | in vitro activation of complement system by lactic acidosis in newborn and adults |
| url | http://dx.doi.org/10.1080/09629350123788 |
| work_keys_str_mv | AT friederikehecke invitroactivationofcomplementsystembylacticacidosisinnewbornandadults AT thomashoehn invitroactivationofcomplementsystembylacticacidosisinnewbornandadults AT evelynstrauss invitroactivationofcomplementsystembylacticacidosisinnewbornandadults AT michaelobladen invitroactivationofcomplementsystembylacticacidosisinnewbornandadults AT josefsonntag invitroactivationofcomplementsystembylacticacidosisinnewbornandadults |