The histone methyltransferase DOT1B is dispensable for stage differentiation and macrophage infection of Leishmania mexicana

The histone methyltransferase DOT1B is dispensable for stage differentiation and macrophage infection of Leishmania mexicana

Conserved histone methyltransferases of the DOT1 family are involved in replication regulation, cell cycle progression, stage differentiation, and gene regulation in trypanosomatids. However, the specific functions of these enzymes depend on the host evasion strategies of the parasites. In this stud...

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Bibliographic Details
Main Authors: Nicole Eisenhuth, Elisa Theres Rauh, Melina Mitnacht, Andrea Debus, Ulrike Schleicher, Falk Butter, Katerina Pruzinova, Petr Volf, Christian J. Janzen
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-01-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
histone methyltransferase
DOT1
Leishmania mexicana
virulence
differentiation
sand fly
Online Access:https://www.frontiersin.org/articles/10.3389/fcimb.2024.1502339/full
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