New Insights into the Pathophysiology of Mild Chronic Obstructive Pulmonary Disease
The classification of mild chronic obstructive pulmonary disease (COPD) requires a postbronchodilator forced expiratory volume in 1 s (FEV1) to forced vital capacity ratio <0.7 and an FEV1 ≥80% predicted. Given their relatively well-preserved spirometry, some have argued that respiratory symptoms...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | Canadian Respiratory Journal |
| Online Access: | http://dx.doi.org/10.1155/2014/580396 |
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| author | Jordan A Guenette |
| author_facet | Jordan A Guenette |
| author_sort | Jordan A Guenette |
| collection | DOAJ |
| description | The classification of mild chronic obstructive pulmonary disease (COPD) requires a postbronchodilator forced expiratory volume in 1 s (FEV1) to forced vital capacity ratio <0.7 and an FEV1 ≥80% predicted. Given their relatively well-preserved spirometry, some have argued that respiratory symptoms in patients with mild COPD are unlikely to be related to pulmonary function abnormalities and that early detection of COPD is a ‘waste of resources’. Despite this viewpoint, there is emerging clinical and physiological evidence of peripheral airway dysfunction, diminished quality of life and reduced physical activity levels, and increased mortality, hospitalizations, dyspnea and exercise intolerance in patients with mild COPD compared with healthy controls. The purpose of the present focused review was to summarize recent research regarding the pathophysiology and treatment of mild COPD. |
| format | Article |
| id | doaj-art-fc2ce675ae454f1ca502de9840a462ae |
| institution | Kabale University |
| issn | 1198-2241 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Respiratory Journal |
| spelling | doaj-art-fc2ce675ae454f1ca502de9840a462ae2025-02-03T00:59:02ZengWileyCanadian Respiratory Journal1198-22412014-01-01211252710.1155/2014/580396New Insights into the Pathophysiology of Mild Chronic Obstructive Pulmonary DiseaseJordan A Guenette0Department of Physical Therapy and Centre for Heart Lung Innovation, University of British Columbia, Vancouver, British Columbia, CanadaThe classification of mild chronic obstructive pulmonary disease (COPD) requires a postbronchodilator forced expiratory volume in 1 s (FEV1) to forced vital capacity ratio <0.7 and an FEV1 ≥80% predicted. Given their relatively well-preserved spirometry, some have argued that respiratory symptoms in patients with mild COPD are unlikely to be related to pulmonary function abnormalities and that early detection of COPD is a ‘waste of resources’. Despite this viewpoint, there is emerging clinical and physiological evidence of peripheral airway dysfunction, diminished quality of life and reduced physical activity levels, and increased mortality, hospitalizations, dyspnea and exercise intolerance in patients with mild COPD compared with healthy controls. The purpose of the present focused review was to summarize recent research regarding the pathophysiology and treatment of mild COPD.http://dx.doi.org/10.1155/2014/580396 |
| spellingShingle | Jordan A Guenette New Insights into the Pathophysiology of Mild Chronic Obstructive Pulmonary Disease Canadian Respiratory Journal |
| title | New Insights into the Pathophysiology of Mild Chronic Obstructive Pulmonary Disease |
| title_full | New Insights into the Pathophysiology of Mild Chronic Obstructive Pulmonary Disease |
| title_fullStr | New Insights into the Pathophysiology of Mild Chronic Obstructive Pulmonary Disease |
| title_full_unstemmed | New Insights into the Pathophysiology of Mild Chronic Obstructive Pulmonary Disease |
| title_short | New Insights into the Pathophysiology of Mild Chronic Obstructive Pulmonary Disease |
| title_sort | new insights into the pathophysiology of mild chronic obstructive pulmonary disease |
| url | http://dx.doi.org/10.1155/2014/580396 |
| work_keys_str_mv | AT jordanaguenette newinsightsintothepathophysiologyofmildchronicobstructivepulmonarydisease |