Antinociceptive Activity of Ethanol Extract from Duguetia chrysocarpa Maas (Annonaceae)
The ethanol extract from the fruits of Duguetia chrysocarpa was evaluated for its antinociceptive activity in chemical and thermal models of nociception in mice. The intraperitoneal administration of the ethanol extract (100, 200, and 400 mg/kg body weight) showed a dose-dependent inhibition of acet...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1100/2012/859210 |
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| author | Jackson Roberto Guedes da Silva Almeida Edigênia Cavalcante da Cruz Araújo Luciano Augusto de Araújo Ribeiro Julianeli Tolentino de Lima Xirley Pereira Nunes Ana Sílvia Suassuna Carneiro Lúcio Maria de Fátima Agra José Maria Barbosa Filho |
| author_facet | Jackson Roberto Guedes da Silva Almeida Edigênia Cavalcante da Cruz Araújo Luciano Augusto de Araújo Ribeiro Julianeli Tolentino de Lima Xirley Pereira Nunes Ana Sílvia Suassuna Carneiro Lúcio Maria de Fátima Agra José Maria Barbosa Filho |
| author_sort | Jackson Roberto Guedes da Silva Almeida |
| collection | DOAJ |
| description | The ethanol extract from the fruits of Duguetia chrysocarpa was evaluated for its antinociceptive activity in chemical and thermal models of nociception in mice. The intraperitoneal administration of the ethanol extract (100, 200, and 400 mg/kg body weight) showed a dose-dependent inhibition of acetic-acid-induced abdominal writhes. The extract also produced a significant inhibition of both phases of the formalin test in all doses tested and increased the reaction time in hot-plate test at dose of 200 mg/kg. The data obtained suggest that the antinociceptive effect of the extract may be mediated via both peripheral and central mechanisms. The phytochemical investigation yielded the isolation of the benzenoid derivative 3-methoxy-4-ethoxy benzoic acid which is being reported for the first time in this genus. |
| format | Article |
| id | doaj-art-fc116c3debaa4466b9e41fd8bff02dc3 |
| institution | Kabale University |
| issn | 1537-744X |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-fc116c3debaa4466b9e41fd8bff02dc32025-02-03T01:20:40ZengWileyThe Scientific World Journal1537-744X2012-01-01201210.1100/2012/859210859210Antinociceptive Activity of Ethanol Extract from Duguetia chrysocarpa Maas (Annonaceae)Jackson Roberto Guedes da Silva Almeida0Edigênia Cavalcante da Cruz Araújo1Luciano Augusto de Araújo Ribeiro2Julianeli Tolentino de Lima3Xirley Pereira Nunes4Ana Sílvia Suassuna Carneiro Lúcio5Maria de Fátima Agra6José Maria Barbosa Filho7Núcleo de Estudos e Pesquisas de Plantas Medicinais, Universidade Federal do Vale do São Francisco, 56.304-205 Petrolina, PE, BrazilNúcleo de Estudos e Pesquisas de Plantas Medicinais, Universidade Federal do Vale do São Francisco, 56.304-205 Petrolina, PE, BrazilNúcleo de Estudos e Pesquisas de Plantas Medicinais, Universidade Federal do Vale do São Francisco, 56.304-205 Petrolina, PE, BrazilNúcleo de Estudos e Pesquisas de Plantas Medicinais, Universidade Federal do Vale do São Francisco, 56.304-205 Petrolina, PE, BrazilNúcleo de Estudos e Pesquisas de Plantas Medicinais, Universidade Federal do Vale do São Francisco, 56.304-205 Petrolina, PE, BrazilLaboratório de Tecnologia Farmacêutica, Universidade Federal da Paraíba, 58.051-970 João Pessoa, PB, BrazilLaboratório de Tecnologia Farmacêutica, Universidade Federal da Paraíba, 58.051-970 João Pessoa, PB, BrazilLaboratório de Tecnologia Farmacêutica, Universidade Federal da Paraíba, 58.051-970 João Pessoa, PB, BrazilThe ethanol extract from the fruits of Duguetia chrysocarpa was evaluated for its antinociceptive activity in chemical and thermal models of nociception in mice. The intraperitoneal administration of the ethanol extract (100, 200, and 400 mg/kg body weight) showed a dose-dependent inhibition of acetic-acid-induced abdominal writhes. The extract also produced a significant inhibition of both phases of the formalin test in all doses tested and increased the reaction time in hot-plate test at dose of 200 mg/kg. The data obtained suggest that the antinociceptive effect of the extract may be mediated via both peripheral and central mechanisms. The phytochemical investigation yielded the isolation of the benzenoid derivative 3-methoxy-4-ethoxy benzoic acid which is being reported for the first time in this genus.http://dx.doi.org/10.1100/2012/859210 |
| spellingShingle | Jackson Roberto Guedes da Silva Almeida Edigênia Cavalcante da Cruz Araújo Luciano Augusto de Araújo Ribeiro Julianeli Tolentino de Lima Xirley Pereira Nunes Ana Sílvia Suassuna Carneiro Lúcio Maria de Fátima Agra José Maria Barbosa Filho Antinociceptive Activity of Ethanol Extract from Duguetia chrysocarpa Maas (Annonaceae) The Scientific World Journal |
| title | Antinociceptive Activity of Ethanol Extract from Duguetia chrysocarpa Maas (Annonaceae) |
| title_full | Antinociceptive Activity of Ethanol Extract from Duguetia chrysocarpa Maas (Annonaceae) |
| title_fullStr | Antinociceptive Activity of Ethanol Extract from Duguetia chrysocarpa Maas (Annonaceae) |
| title_full_unstemmed | Antinociceptive Activity of Ethanol Extract from Duguetia chrysocarpa Maas (Annonaceae) |
| title_short | Antinociceptive Activity of Ethanol Extract from Duguetia chrysocarpa Maas (Annonaceae) |
| title_sort | antinociceptive activity of ethanol extract from duguetia chrysocarpa maas annonaceae |
| url | http://dx.doi.org/10.1100/2012/859210 |
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