Recent Advances, Research Trends, and Clinical Relevance of Hyaluronic Acid Applied to Wound Healing and Regeneration
Hyaluronan (HA) is a ubiquitous macromolecule in the human body with remarkable structure and function. HA presents a key role in several biological processes in mammals. The synthesis/catabolism of HA is critical in several pathologies and has been used as a marker for the prognosis of cancers. Amo...
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MDPI AG
2025-01-01
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| author | Gloria Huerta-Ángeles Edgar Mixcoha |
| author_facet | Gloria Huerta-Ángeles Edgar Mixcoha |
| author_sort | Gloria Huerta-Ángeles |
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| description | Hyaluronan (HA) is a ubiquitous macromolecule in the human body with remarkable structure and function. HA presents a key role in several biological processes in mammals. The synthesis/catabolism of HA is critical in several pathologies and has been used as a marker for the prognosis of cancers. Among its physiological roles, HA is used for wound healing applications. This review reports many of the latest developments of hyaluronan and its derivatives in research, preclinical, and published clinical trials for wound healing. An adequate physico-chemical characterization and identification of selected physico-chemical properties of the prepared material are mandatory. Moreover, cytotoxicity and evaluation of biological effects in vitro using standardized protocols are required as preclinical. Finally, to choose adequate in vivo models for testing efficacy is requested. Unfortunately, the biological role of HA is still not well understood. Therefore, an overview of several HA-based products is provided and discussed. Several ways of HA chemical modification were evaluated. Finally, this review focuses on products containing HA, novel developments, gaps, and limitations of the current state of the art. |
| format | Article |
| id | doaj-art-fbfbac7e73f54437a91ce4cb25c5ac7d |
| institution | Kabale University |
| issn | 2076-3417 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
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| series | Applied Sciences |
| spelling | doaj-art-fbfbac7e73f54437a91ce4cb25c5ac7d2025-01-24T13:19:50ZengMDPI AGApplied Sciences2076-34172025-01-0115253610.3390/app15020536Recent Advances, Research Trends, and Clinical Relevance of Hyaluronic Acid Applied to Wound Healing and RegenerationGloria Huerta-Ángeles0Edgar Mixcoha1Institute of Macromolecular Chemistry of the Czech Academy of Sciences, Heyrovského nam. 2, 162 06 Prague, Czech RepublicCONAHCYT-INMEGEN, Periferico Sur 4809, Arenal Tepepan, Tlalpan, Mexico City 14610, MexicoHyaluronan (HA) is a ubiquitous macromolecule in the human body with remarkable structure and function. HA presents a key role in several biological processes in mammals. The synthesis/catabolism of HA is critical in several pathologies and has been used as a marker for the prognosis of cancers. Among its physiological roles, HA is used for wound healing applications. This review reports many of the latest developments of hyaluronan and its derivatives in research, preclinical, and published clinical trials for wound healing. An adequate physico-chemical characterization and identification of selected physico-chemical properties of the prepared material are mandatory. Moreover, cytotoxicity and evaluation of biological effects in vitro using standardized protocols are required as preclinical. Finally, to choose adequate in vivo models for testing efficacy is requested. Unfortunately, the biological role of HA is still not well understood. Therefore, an overview of several HA-based products is provided and discussed. Several ways of HA chemical modification were evaluated. Finally, this review focuses on products containing HA, novel developments, gaps, and limitations of the current state of the art.https://www.mdpi.com/2076-3417/15/2/536hyaluronanmolecular weightclinical trialswound healing |
| spellingShingle | Gloria Huerta-Ángeles Edgar Mixcoha Recent Advances, Research Trends, and Clinical Relevance of Hyaluronic Acid Applied to Wound Healing and Regeneration Applied Sciences hyaluronan molecular weight clinical trials wound healing |
| title | Recent Advances, Research Trends, and Clinical Relevance of Hyaluronic Acid Applied to Wound Healing and Regeneration |
| title_full | Recent Advances, Research Trends, and Clinical Relevance of Hyaluronic Acid Applied to Wound Healing and Regeneration |
| title_fullStr | Recent Advances, Research Trends, and Clinical Relevance of Hyaluronic Acid Applied to Wound Healing and Regeneration |
| title_full_unstemmed | Recent Advances, Research Trends, and Clinical Relevance of Hyaluronic Acid Applied to Wound Healing and Regeneration |
| title_short | Recent Advances, Research Trends, and Clinical Relevance of Hyaluronic Acid Applied to Wound Healing and Regeneration |
| title_sort | recent advances research trends and clinical relevance of hyaluronic acid applied to wound healing and regeneration |
| topic | hyaluronan molecular weight clinical trials wound healing |
| url | https://www.mdpi.com/2076-3417/15/2/536 |
| work_keys_str_mv | AT gloriahuertaangeles recentadvancesresearchtrendsandclinicalrelevanceofhyaluronicacidappliedtowoundhealingandregeneration AT edgarmixcoha recentadvancesresearchtrendsandclinicalrelevanceofhyaluronicacidappliedtowoundhealingandregeneration |